Sucralfate medicine: uses, usage and Dosage


What is sucralfate?

Sucralfate medicine is an aluminum-containing gastric mucosal protective drug, available in tablet and emulsion forms on the market.

How does sucralfate work?

It is used to treat and prevent duodenal ulcers and other conditions as directed by your doctor. It works by forming a barrier or coating over the sore. This protects the ulcer from acid in the stomach, allowing it to heal. 

Sucralfate drug information

  • Registration Number: VD-14442-11;
  • Active ingredient – ​​content: Sucralfate 1g;
  • Packing: Box of 2 blisters x 10 tablets;
  • Expiry date: 36 months;
  • Gastrointestinal drug group

Indications & contraindications to the use of sucralfate

Indication of drugs

  • Treatment of gastric and duodenal ulcers,
  • Chronic gastritis, benign ulcer.
  • Prevention of duodenal ulcer recurrence, stomach ulcer due to stress.
  • Treatment of gastroesophageal reflux disease.

Contraindications to the drug

The drug is contraindicated in patients with hypersensitivity to the components of the drug.

Dosage of sucralfate

Dosage for adults

Dosage is based on your medical condition and response to treatment.

Usual Adult Dose for Prophylaxis of Gastrointestinal Bleeding from Stress Ulcers:

  • You take 1g orally 6 times a day. However, you need to be careful not to take more than 8 g a day.

Usual Adult Dose for Chronic Gastritis:

  • You take 1g orally 4 times a day or take 2g orally for 4-8 weeks or possibly for 12 weeks if needed. Maintenance dose of 1 g to prevent recurrence. The maximum dose is 8 g a day.

Dosage for children

Usual pediatric dose for the prophylaxis of peptic ulcer bleeding due to stress, treatment of chronic peptic ulcer:

You give your child the dose according to the age of the child as follows:

  • Children 1 month to 2 years old, you give them 250mg orally 6 times a day;
  • Children 2-12 years old, you give them 500 mg orally 4-6 times a day;
  • Children 12-18 years old, you give them 1g to drink 4-6 times a day.

How to take medicine

  • Take sucralfate exactly as prescribed by your doctor. Follow all directions on your medication label and read all medication instructions or instruction sheets.
  • Take this medication by mouth, usually 2 to 4 times daily, on an empty stomach at least 1 hour before meals or as directed by your doctor.
  • The dosage is based on your medical condition and response to therapy.

Precautions while using sucralfate

  • Use with caution in patients with renal impairment due to the increased risk of serum aluminum accumulation; especially when taking the drug for a long time.
  • In the case of patients with severe renal impairment, the drug should be avoided in these subjects.
  • Be careful to avoid prolonged treatment in patients with renal impairment. 
  • For pregnant women should be cautious and only use when absolutely necessary

What to do in case of overdose?

Overdose symptoms

  • Undigested;
  • Nausea;
  • Vomiting;
  • Stomachache.

Treatment in case of overdose

  • Call 911 immediately or go to the nearest local health station.
  • Of course, you’ll need to keep a record and bring a list of all the medications you’ve taken, including prescription and over-the-counter drugs.

What should I do if I miss a dose?

  • If you forget to take a dose, take it as soon as possible.
  • But if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time.
  • Do not take double the prescribed dose.

Side effects of medications

Get emergency medical help if you have signs of an allergic reaction: hives; shortness of breath; swelling of the face, lips, tongue, or throat.

Common side effects may include:

  • Constipation, diarrhea;
  • Nausea, vomiting, abdominal pain;
  • Itching, rash;
  • Dizziness, drowsiness;
  • Sleep problems (insomnia);
  • Headache;
  • Backache.

This is not a complete list of side effects and other possible side effects. Call your doctor for medical advice about side effects.

Sucralfate drug interactions 

Other drugs may affect sucralfate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any you start or stop using.

Drug interactions with sucralfate

  • Low-intensity aspirin ( aspirin );
  • Benadryl (diphenhydramine);
  • Cymbalta (duloxetine);
  • Dexilant (dexlansoprazole), digoxin, fish oil (omega-3 polyunsaturated fatty acids);
  • Lyrica (pregabalin);
  • Metoprolol Succinate ER (metoprolol), metoprolol Tartrate (metoprolol);
  • Nexium (esomeprazole), Norco (acetaminophen / hydrocodone);
  • omeprazole;
  • pantoprazole, Pepcid (famotidine), Prilosec (omeprazole), ProAir HFA (albuterol), Protonix (pantoprazole);
  • ranitidine;
  • Singulair (montelukast);
  • Tylenol (acetaminophen);
  • Vitamin B12 (cyanocobalamin), Vitamin C (axit ascorbic), Vitamin D3 (cholecalciferol);
  • Xanax (alprazolam);
  • Zantac (ranitidine), Zofran (ondansetron), Zyrtec (cetirizine).

What is the pharmacokinetics of the drug?

Up to 5% of the disaccharide fraction and less than 0.02% of aluminum are absorbed into the body after a single dose of the drug. Most of the drug is excreted in the feces. Only a very small amount of sucralfate is absorbed by the gastrointestinal tract and is eliminated by the kidneys.

The above article is for reference only and is not a substitute for medical diagnosis or treatment. Readers should only follow the instructions of the doctor who is treating you, Index-China disclaims responsibility if problems occur.


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