What is Sibelium?
Flunarizine, sold under the brand name Sibelium medicine among others, is a medication classified as a calcium antagonist used for various indications.
This medication is not available by prescription in the United States or Japan. The drug was discovered at Janssen Pharm Pharmaceuticals (R14950) in 1968.
Sibelium drug information
- Ingredients of Sibelium: Flunarizine – 5mg
- Registration Number: VN-10210-05
- Packing: Box of 10 blisters; 50 blisters x 10 capsules
How does Sibelium work?
Migraines are thought to be the result of dilation of blood vessels in the head. Sibelium works by preventing loss of tone and dilation of blood vessels, thus preventing migraines.
Indications for the use of Sibelium
Sibelium is used in the following cases:
- Preventing Migraines
- Obstructive peripheral vascular disease
- Dizziness of central and peripheral origin
What is the dose of Sibelium ?
Always consult your doctor or pharmacist before deciding to take a medication.
- The recommended adult dose of Sibelium is: 10 mg daily, taken in the evening with or without food. People with side effects can take 5 mg per day in the evening to be effective.
How to take Sibelium
Take this medication as directed by your doctor. Do not take in larger amounts than recommended.
The drug should be taken at night, before going to bed because this medicine causes drowsiness and somnolence.
The effects of flunarizine may not be seen for several weeks. Do not stop taking the medication due to failure within the first six to eight weeks.
Do not stop using this medicine without consulting your doctor because stopping treatment suddenly can cause serious side effects.
Contraindications to the use of Sibelium
This medication is not recommended for use in patients with a history of allergy to Flunarizine or any of the other inactive ingredients in the formulation.
This medicine is not recommended for use in patients with Parkinson’s disease.
Precautions while using Sibelium
Depression: Use may cause lack of interest, low mood, and sleep disturbances in some patients. It should be used with caution in patients with active or past depression.
Reduced alertness: Use may cause drowsiness and somnolence in some patients. We recommend that you do not perform any activities such as driving or operating machinery if you experience any of these symptoms.
Liver disease: Sibelium should be used with caution in people with impaired liver function due to the increased risk of side effects. Liver function tests should be closely monitored while taking this medicine.
Glaucoma: The drug should be used with caution in patients with glaucoma due to the increased risk of side effects. Immediately report any vision disturbances, pain, or dry eyes to your doctor.
Gastrointestinal obstruction: The drug is not recommended for use in patients with partial or total intestinal obstruction. The risk of side effects is significantly high and therefore a suitable alternative medicine can be recommended.
Urinary tract obstruction: Sibelium is not recommended for use if you have a partial or complete blockage of your urinary tract. The risk of side effects is significantly high and therefore a suitable alternative medicine can be recommended.
Porphyria: The drug is not recommended for use if you have a genetic disorder of the blood and skin (Porphyria). The risk of side effects is significantly high and therefore a suitable alternative medicine can be recommended.
Pregnancy: The drug is not recommended during pregnancy unless absolutely necessary. All risks and benefits should be discussed with your doctor before taking this medicine.
Lactation: The drug is not recommended for use by women who are breastfeeding unless absolutely necessary. All risks and benefits should be discussed with your doctor before taking this medicine.
Children: Sibelium is not recommended for use in patients under 18 years of age because safety and efficacy have not been clinically established.
Elderly: Sibelium should be used with caution in the elderly. The risk of side effects is significantly high and treatment should therefore be initiated at the lowest possible dose.
What to do in case of overdose?
Seek emergency medical treatment or contact a doctor in case of overdose.
What should I do if I miss a dose?
Take that dose as soon as you remember. If it is almost time for the next scheduled dose, the missed dose can be skipped.
Sibelium side effects
Sibelium can cause side effects, such as:
- Dizziness or lightheadedness
- Dry mouth
- Flushing and warm feeling
- Increased appetite or weight gain
- Unusual fatigue or weakness
This is not a complete list of side effects and others may occur. If you have any questions about side effects, consult your doctor or pharmacist.
What other medicines does Sibelium interact with?
Drugs that may interact with Sibelium include:
- Oral contraceptives: Galactorrhoea has been reported in some women on oral contraceptives
- Carbamazepine and Phenytoin: Inducers of liver enzymes such as carbamazepine and phenytoin may interact with flunarizine by increasing its metabolism.
- CNS depressants, Triprolidine and Flunarizine: May increase hypersensitivity side effects. Monitor for an increase in CNS depressant effects with concomitant treatment.
To avoid drug interactions, it’s best to write down a list of all the medications you’re taking (including prescription, over-the-counter, herbal and dietary supplements) and show them to your doctor or pharmacist. To ensure safety when taking the drug, do not arbitrarily take the drug, stop or change the dose of the drug without the permission of the doctor.
How to store Sibelium?
- Store the medicine at room temperature below 30°C, away from moisture and light.
- Keep medicine in a safe place, out of reach of children and pets.
The above article is for reference only and is not a substitute for medical diagnosis or treatment. Readers should only follow the instructions of the doctor who is treating you, Index-China disclaims responsibility if problems occur.
Reputable source ThuocLP Vietnamese: Sibelium medicine: Uses, dosage & usage
Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.