Rodogyl medicine: uses, usage and dosage


Basic information about Drugs Rodogyl 750,000IU / 125mg Spiramycin & Metronidazole treats and prevents bacterial infections.

  • Brand Name: Rodogyl
  • Active ingredients: Spiramycin & Metronidazole
  • Hàm lượng: 750.000IU & 125mg (Spiramycin 750.000IU & Metronidazole 125mg)
  • Packing: 1 box of 20 tablets
  • Producer: Sanofi aventis
  • Drug Prices: COMMENT below for prices.
  • group of antibiotics – antiviral drugs

Uses / Indications for treatment of Rodogyl

Rodogyl medicine is used to treat:

  1. Treatment and prevention of acute, chronic or recurrent oral infections: such as tooth abscess or periodontitis.
  2. Oropharyngeal infections caused by anaerobic bacteria.
  3. Ear infections and sinusitis.
  4. Prevention of local infection complications after oral surgery.
  5. Efficacy in the prevention of infective endocarditis has not been demonstrated.

Mechanism of action of Spiramycin & Metronidazole

Rodogyl is a combination of the antibiotic spiramycin of the macrolide family and the antibiotic metronidazole of the nitro-5-imidazole family, specifically for infectious oral disease.


  1. Do not use Rodogyl in patients who are hypersensitive to any of the ingredients in the drug.
  2. The bristles are recommended for use by pregnant and lactating women.
  3. Not to be used in children under 6 years of age.
  4. Contraindicated in case of fructose intolerance.

Dosage and how to use Rodogyl

Recommended dosage

  1. Adults: 4-6 tablets orally 2-3 times daily (equivalent to 3 – 4.5 million lU of spiramycin and 500 – 750 mg
  2. metronidazole).
  3. Children 6 – 10 years: 2 tablets orally twice daily (equivalent to 1.5 million lU of spiramycin and 250 mg
  4. metronidazole).
  5. Children 10 to 15 years: 3 tablets orally 2 to 3 times daily (equivalent to 2.25 million IU of spiramycin and 375 mg of metronidazole).


  1. Use Rodogyl at the exact dose prescribed by your doctor.
  2. Take the tablet whole with a glass of water and should be taken immediately after a meal.

Warnings and Precautions while using Rodogyl

Before using Rodogyl, tell your doctor if you have the following medical problems:

  1. Nervous disorders
  2. Psychosis,
  3. Blood disorders,
  4. History of meningitis with metronidazole.

Fructose intolerance (rare genetic disease). Subsequent use of Rodogyl is not recommended because of the presence of sorbitol.

you already have heart problems: you should be careful with this medicine if you were born or have a family history of QT prolongation

You or a member of your family has glucose-6-phosphate dehydrogenase deficiency (inherited erythrocytosis) because of the risk of red blood cell destruction with spiramycin in the medicine.

Rodogyl should not be used in cases of fructose intolerance (inherited metabolic disease). Due to the presence of sorbitol in the medicine.

Rodogyl side effects

Common side effects of the drug:

  1. Stomach pain
  2. Nausea and vomiting
  3. Diarrhea
  4. Colitis
  5. Itchy urticarial rash

Side effects associated with Spiramycin:

  1. Abnormal heart rhythms such as: QT prolongation
  2. Digestive disorders such as: diarrhea, stomach pain
  3. Skin and subcutaneous tissue disorders such as: rash, urticaria, itching
  4. Central and peripheral nervous system disorders such as dyslexia, transient paresthesia
  5. Hepatobiliary disorders: such as cholestatic hepatitis
  6. Blood and lymphatic system disorders: leukopenia, anemia

Side effects associated with Metronidazole:

  1. Blood and lymphatic system disorders such as: leukopenia, anemia
  2. Psychiatric disorders such as: hallucinations, paranoia
  3. Nervous system disorders such as: peripheral neuropathy, headache, convulsions
  4. Eye disorders such as: blurred vision, decreased vision, optic neuritis
  5. Digestive disorders such as: nausea and vomiting, diarrhea, pancreatitis, dry mouth
  6. Hepatobiliary disorders such as: increased liver enzymes, liver failure
  7. Skin and subcutaneous tissue disorders: pruritus, febrile rash, urticaria, Steven-Johnson syndrome

Other drug interactions with Rodogyl

Related interactions with spiramycin:

  • Use caution when co-administering levodopa and carbidopa, as spiramycin reduces the effects of these drugs.

Interactions with metronidazole:

  • If you are taking disulfiram, do not take metronidazole at the same time or for at least two weeks after the end of disulfuram treatment, as this may lead to hallucinations and confusion.
  • Drinks or medicines containing alcohol must be avoided because many unpleasant reactions, known as disulfiram-like effects, may occur, including: burning sensation, skin redness, vomiting, nausea, sweating and drumming. chest.

Caution must be taken if you take metronidazole with:

  • Oral anticoagulants because of possible increased risk of bleeding: lithium, ciclosporin and phenytoin.
  • Phenobarbital, antacids (aluminum hydroxide) and prednisone because these drugs may decrease the effectiveness of metronidazole.
  • Cimetidine may potentiate or increase the toxicity of metronidazole.
  • Busulfan: because metronidazole may be an increase in toxicity and plasma concentrations of this drug.
  • Metronidazole increases the toxicity of 5-fluorouracil and may give false-positive results on tests for syphilis.

Preservation of drugs

  • Store the drug at a temperature not exceeding 25 ° C.
  • Keep medicine out of reach of children and pets.

Note: Information about the article about the drug Rodogyl 750,000IU / 125mg Spiramycin & Metronidazole for the purpose of sharing knowledge for reference only, patients are not allowed to use the drug on their own, all information on drug use must be as indicated. specialist doctor.


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