Yervoy 5mg / ml Ipilimumab treatment of skin and kidney cancer. You need to know how much does Ipilimumab cost? Don’t know where Yervoy is sold?
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Basic information about Yervoy medicine 5mg/ml Ipilimumab for skin and kidney cancer
- Brand name: Yervoy
- Active ingredient: Ipilimumab
- Content: 5mg / ml (50mg / 10ml & 200mg / 40ml)
- Form: Infusion solution
- Packaging: Each ml of concentrate contains 5 mg of Ipilimumab (One 10 ml vial contains 50 mg ipilimumab & One 40 ml vial contains 200 mg ipilimumab.)
- Manufacturer: Bristol – Myers Squibb
- Yervoy Drug Prices: COMMENT below for prices OR Click on the link: https://thuoclp.com/chatFB type “Yervoy”
What is Yervoy? Indications for treatment of Ipilimumab medication?
Yervoy is a type of treatment of metastatic melanoma called immunotherapy, which usually works by stimulating people’s own immune systems, defending the body’s nature.
What does the immune system have to do with metastatic melanoma?
Your immune system is your body’s natural defense, helping to protect you from disease.
When the immune system works normally, a group of cells called T cells look for harmful cells, such as melanoma and eliminate them. Sometimes, T cells do not work well against cancer cells in people with undetectable or metastatic melanoma, which is where immunotherapy like Yervoy attaches.
In fact, there’s a whole field called immune cancer, helping doctors and scientists understand how immune therapies like Yervoy can help the immune system fight cancer.
Yervoy is used to treat
Melanoma
- Yervoy is a monotherapy indicated for the treatment of advanced irreplaceable or metastatic melanoma in adults and adolescents 12 years and older.
- Yervoy in combination with nivolumab is indicated for the treatment of advanced irreversible or metastatic melanoma in adults.
- Yervoy is a prescription drug used in adults to help prevent melanoma from coming back after it and the cancer-containing lymph nodes have been surgically removed.
Renal cell carcinoma (RCC)
- Yervoy in combination with nivolumab is indicated for the first-line treatment of adult patients with moderate or worse renal cell carcinoma.
The mechanism of action of Ipilimumab
The active substance Ipilimumab is a monoclonal antibody. A monoclonal antibody is a protein that has been designed to recognize and attach to a specific target in the body.
Ipilimumab is believed to work with the body’s immune system to enhance the activity of the T cells that everyone has. And when T cells are more active, it can help the body fight cancer.
Dosage and usage of Yervoy
Dosage recommended
Yervoy dosage for Malignant tumor: 3 mg / kg intravenously at intervals of 90 minutes every 3 weeks for a total of 4 doses.
Dosage of Yervoy in combination with Nivolumab
Melanoma
The recommended dose is 3 mg / kg of Yervoy combined with 1 mg / kg of Nivolumab intravenously every 3 weeks for the first 4 doses.
Thereafter, the second stage is followed by nivolumab monotherapy administered intravenously at 240 mg every 2 weeks or at 480 mg every 4 weeks. For the monotherapy period, the first dose of Nivolumab should be used:
- 3 weeks after the last dose of a combination of Nivolumab and Yervoy if used 240 mg every 2 weeks.
- 6 weeks after the last dose of the combination of Nivolumab and Yervoy if used 480 mg every 4 weeks.
Renal cell carcinoma
The recommended dose is 1 mg / kg of Yervoy combined with 3 mg / kg of Nivolumab intravenously every 3 weeks for the first 4 doses.
Thereafter, the second stage is followed by Nivolumab monotherapy administered intravenously at a dose of 240 mg every 2 weeks or at 480 mg every 4 weeks. For the monotherapy period, the first dose of Nivolumab should be used:
- 3 weeks after the last dose of the combination Yervoy and Nivolumab, if used 240 mg every 2 weeks.
- 6 weeks after the last dose of the combination Yervoy and Nivolumab, if used 480 mg every 4 weeks.
Using
Yervoy can only be used with a prescription and treatment should be started and supervised by a specialist with experience in cancer treatment.
Yervoy is administered by instillation into a vein for more than 90 minutes and the dose depends on the patient’s body weight.
When using Yervoy alone, patients will receive one dose every 3 weeks for a total of 4 doses.
When used with nivolumab, patients will receive a dose of Yervoy and nivolumab every 3 weeks for 4 doses followed by nivolumab only.
Your doctor may delay the dose if certain side effects occur and discontinue treatment completely if the side effects are severe.
Warnings and precautions when using Yervoy
Autoimmune disease: If you have an autoimmune disease, such as lupus, using Yervoy can make the condition worse by stimulating your immune system.
Drowsiness, decreased alertness: Yervoy can cause fatigue or fatigue, affecting your ability to drive or operate machines.
Immune system reactions: Yervoy can cause inflammation in many parts of the body including the stomach, liver, skin, nerves, hormonal glands (pituitary, adrenal, thyroid) and eyes. .
Infusion reaction: This drug may cause hypersensitivity reactions or infusion. Symptoms of this type of reaction usually appear during the infusion and may include flushing, chest pain, shortness of breath, and sudden drop in blood pressure.
Liver function: Yervoy may cause liver damage or impair liver function.
Kidney problems: Yervoy can cause serious kidney problems including kidney inflammation and kidney failure.
Bowel problems: inflammation of the intestines and stomach can worsen bleeding or perforation.
Lung problems: such as difficulty breathing or coughing, this can be a sign of pneumonia (pneumonia or interstitial lung disease).
Transplant versus host disease: a complication that can occur after a bone marrow transplant using a donor (allogeneic) stem cell, which can be serious and can be fatal, if you receive Yervoy before or after transplantation.
Pregnancy: Yervoy can harm a developing baby if the mother uses this medication during pregnancy.
Breastfeeding: This drug passes into breast milk. If you are a nursing mother and are taking Yervoy, it could affect your baby.
Yervoy side effects
The most common side effects when using Yervoy:
- Loss of appetite
- Diarrhea
- Nausea or vomiting
- Stomachache
- Itching, skin rash
- Feeling tired or weak
- Ho
- Headache
- Fever
- Insomnia
Check with your doctor as soon as possible if any of the following side effects occur:
- Behavioral change
- Dizzy
- Sore eyes or redness
- Fainting
- Headache
- Numbness or tingling in hands or feet
- Signs of bleeding in the stomach such as bloody, black or tarry stools, spitting up blood, vomiting blood or material that looks like coffee grounds
- Symptoms of intestinal inflammation include: diarrhea, blood in stool, stomach pain or pain
- Symptoms of liver problems such as nausea, vomiting, diarrhea, loss of appetite, weight loss, jaundice or white eyes, dark urine, pale stools
- Symptoms of dermatitis such as: skin rash, blistering, peeling skin
- Unusual tiredness or drowsiness
- Weakness in arms, legs or face
- Vision changes: blurred vision or double vision
Other drug interactions with Yervoy
There may be an interaction between Yervoy and some of the following drugs:
- Drugs that suppress the immune system such as anticancer drugs, corticosteroids, mycophenolate, tacrolimus, cyclosporine. Yervoy works by stimulating the immune system. If you have an organ transplant, this medicine may cause your body to refuse organ.
- Vemurafenib
Drug Yervoy 5mg/ml Ipilimumab cost?
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Where is Yervoy 5mg / ml Ipilimumab purchased and sold?
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- LP Drugs Share Knowledge , Do Not Purpose In Yervoy. Readers contact major pharmacies in Ho Chi Minh City, Hanoi, Da Nang, Can Tho … and nationwide. Knowledge information is for reference only, the item must follow the doctor’s appointment, we disclaim responsibility.
Sources of reference to Yervoy medicine:
- Source medicines. org.uk article Yervoy 5 mg / ml concentrate for solution for infusion : https://www.medicines.org.uk/emc/product/4683/smpc , updated October 9, 2019.
- Source yervoy.com article What is Yervoy : https://www.yervoy.com/metastatic/what-is-yervoy
- Source reputable nhathuoclanphuong. net synthesizing the article Yervoy medicine 5mg / ml Ipilimumab for treatment of skin and kidney cancer: https://index-china.com/product/yervoy-medicine-5mg-ml-ipilimumab/ , updated on 12/12/2019 .
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Note: Information about the article about medicine Yervoy 5mg / ml Ipilimumab for the purpose of sharing knowledge for reference only, patients are not allowed to use the drug themselves, all information on drug use must follow the appointment of a specialized physician subjects.
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