Information Xeltabine 500mg Capecitabine treats rectal cancer ung
- Brand Name: Xeltabine .
- Active ingredient: Capecitabine .
- Manufacturer: TEVA.
- Content: 500mg.
- Form: Tablets.
- Packaging: Box of 120 tablets.
Xeltabine 500mg What is Capecitabine?
Xeltabine medicine contains the active ingredient capecitabine, a medicine used to treat cancer that interferes with the growth of cancer cells and slows their spread in the body.
It is used to treat colon cancer and breast or colorectal cancer that has spread to other parts of the body. It is often used in combination with other cancer drugs or radiation treatments.
Capecitabine’s mechanism of actioXeltabine medicine 500mg Capecitabine treats rectal cancer rectaln
The active ingredient capecitabine is a non-cytotoxic fluoropyrimidine carbamate that functions as an oral prodrug of the cytotoxic 5-fluorouracil (5-FU) class. Capecitabine is activated through several enzymatic steps.
The enzyme involved in the final conversion to 5-FU, thymidine phosphorylase (ThyPase), is found in tumor tissues, but also in normal tissues, although usually at lower levels.
In human cancer xenograft models, capecitabine has demonstrated synergistic effects when combined with docetaxel, possibly related to the upregulation of thymidine phosphorylase by docetaxel.
Indications for the treatment of Xeltabine
- Drugs Xeltabine is indicated for the treatment of advanced gastric cancer.
- Docetaxel in combination with docetaxel is indicated for the treatment of patients with locally advanced or metastatic breast cancer following failure of chemotherapy. Prior therapy should include anthracycline.
- Indicated as monotherapy for the treatment of patients with locally advanced or metastatic breast cancer following failure of an anthracycline-containing chemotherapy regimen.
- Indicated for the adjuvant treatment of patients following surgery for Dukes stage III (stage C) colon cancer.
- Xeltabine is indicated for the treatment of metastatic colorectal cancer/
Contraindications to Xeltabine treatment
- History of severe reaction to fluoropyrimidine therapy,
- Hypersensitivity to capecitabine or to any of the excipients.
- In patients with complete dihydropyrimidine dehydrogenase (DPD) deficiency.
- During pregnancy and lactation.
- In patients with severe leukopenia, neutropenia or thrombocytopenia.
- In patients with severe hepatic impairment.
- In patients with severe renal impairment (creatinine clearance less than 30 ml/min).
- Treated or concurrently with brivudine.
Dosage of Xeltabine
- Breast cancer monotherapy dose: Use 1250 mg/m2 x 2 times/day (morning & evening) for 2 weeks, then take a 1-week break in a 3-week cycle.
- Combination dose with Docetaxel for breast cancer treatment: 1250mg/m2 orally twice a day (morning and evening; equivalent to a total dose of 2500 mg/m2 daily) for 2 weeks, then 1 break. with docetaxel 75 mg/m2 as an IV infusion over 1 hour every 3 weeks.
- Dosage for colorectal cancer: The recommended dose is 1000 mg/m2 x 2 times/day for 2 weeks. Then take a 1 week break, combine Oxaliplatin 130 mg/m2 intravenously over 2 hours on the first day of every 3 weeks. Conduct the course within 24 weeks. Patients should be pre-prepared with antiemetics before taking Oxaliplatin.
- Recommended dose for stomach cancer: Use 1000 mg/m2 x 2 times/day, apply for 14 days. Then take a 7-day break, combine with Cisplatin 80 mg/m2 intravenously over 2 hours every 3 weeks. Patients should be prepared with water and antiemetics before taking Cisplatin.
For children: Currently, the dose for children under 18 years of age has not been studied and determined. So if you want to use it for children, you need to discuss it carefully with your doctor, weigh the risks and risks before applying.
How to take medicine
- Xeltabine is usually taken twice daily. Follow the directions on your medicine label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
- Xeltabine is a 3-week treatment cycle and you only need to take it for the first 2 weeks of each cycle. Your doctor will determine how long to treat you with the medicine.
- The drug should be taken with food or within 30 minutes after eating a meal.
- Take the medicine with a full glass of water.
- You may need frequent medical tests to make sure this medicine is not causing harmful effects.
What to do in case of overdose?
- Call 911 immediately or go to the nearest local health station.
- Of course, you’ll need to keep a record and bring a list of all the medications you’ve taken, including prescription and over-the-counter drugs.
What should I do if I miss a dose?
- If you forget to take a dose, take it as soon as possible.
- But if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time.
- Do not take double the prescribed dose.
Precautions before using Xeltabine
Before using Xeltabine in any of the following situations:
- If you have liver or kidney disease.
- If you have another medical condition such as: heart disease or chest pain, or if you have brain disease (for example, cancer or nerve spread to the brain).
- If you have a calcium imbalance (detected in blood tests)
- Have diabetes.
- If an imbalance of ions in the blood.
Make sure your doctor knows about it. Consult your doctor if these reminders apply to you at any time in the past.
For pregnant or lactating women
- Consult your doctor or pharmacist before using this medicine.
- If you are pregnant or if you think you may be, you should not use Xeltabine .
- If you think you are pregnant before treatment, or if you plan to become pregnant, tell your doctor.
- Consult your doctor or pharmacist before using Xeltabine medicine.
- If you are breast-feeding you should not take this medicine.
Xeltabine side effects
Get emergency medical help if you have signs of an allergic reaction to Xeltabine: hives; shortness of breath; swelling of your face, lips, tongue, or throat.
Call your doctor right away if you have:
- Symptoms of dehydration: feeling very thirsty or hot, unable to urinate, sweating a lot, or hot and dry skin;
- heart problems: chest pain or pressure, irregular heartbeat, trouble breathing (even with mild exertion), swelling or rapid weight gain;
- Kidney problems: little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;
- liver problems: nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);
- low blood cell counts: fever or other flu symptoms, cough, skin sores, pale skin, easy bruising, unusual bleeding, feeling light-headed, fast heartbeat;
- Severe skin reaction: fever, sore throat, swelling in the face or tongue, burning in the eyes, skin pain, followed by a red or purple skin rash that spreads (especially to the face or upper body) and causes swelling blistering and peeling.
Common side effects of taking Xeltabine may include:
- stomach pain or discomfort, constipation;
- Feeling tired;
- Spider skin rash
- Numbness or tingling in your hands or feet.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Drug interactions with Xeltabine 500mg Capecitabine
If you take blood thinners (warfarin, Coumadin, Jantoven), you may need to check your “INR” or prothrombin time more often.
Taking blood thinners can increase your risk of serious bleeding while you are using Xeltabine and for a short time after you stop taking it. This risk is higher in adults over 60 years of age.
Other drugs may interact with Capecitabine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your healthcare providers about all the medicines you use now and any medicines you start or stop using.
How much does Xeltabine 500mg cost?
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Preservation of drugs
- Store the medicine at room temperature, away from heat and direct light. Do not freeze medication unless required by package insertion. Keep medicine away from children and pets.
- Do not flush medications down the toilet or pour them into the sewer system unless instructed to do so. Drugs discarded in this way can contaminate the environment.
The above article is for reference only and is not a substitute for medical diagnosis or treatment. Readers should only follow the instructions of the doctor who is treating you, Index-China disclaims responsibility if problems occur.
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Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.