Xarelto 10mg Rivaroxaban prevents venous thromboembolism. You need to know how much Rivaroxaban costs? You do not know where Xarelto is sold? LP is an address specializing in buying and selling Xarelto medicine in Ho Chi Minh City, Hanoi, Da Nang, Can Tho … and nationwide.
Basic information about Xarelto 10mg Rivaroxaban Drugs prevents venous thromboembolism
- Brand name: Xarelto
- Active ingredient: Rivaroxaban
- Content: 10mg
- Form: Tablets
- Package: 1 box of 10 tablets
- Xarelto Medication Price: COMMENT below for price OR Click on the link: https://thuoclp.com/chatFB type “Xarelto”
What is Xarelto medicine ?
- Xarelto contains the active ingredient Rivaroxaban and is used in adults for
- prevent blood clots in veins after hip or knee replacement surgery. Your doctor has prescribed this medicine for you because after surgery you risk blood clots.
- treat blood clots in your leg veins (deep vein thrombosis) and in the blood vessels of the lungs (pulmonary embolism), and to prevent blood clots from reappearing in the blood vessels of your legs and / or lung.
- Xarelto belongs to a group of drugs called anti-thrombotic drugs. It works by blocking a blood clotting factor (Xa factor) and thus reducing the tendency for blood to clot.
Mechanism of action
- Rivaroxaban is a highly selective direct factor inhibitor with oral bioavailability.
- Inhibition of factor Xa disrupts the intrinsic and exogenous pathways of blood clotting, inhibits both thrombin formation and thrombi development.
- Rivaroxaban does not inhibit thrombin and has no proven effect on platelets.
- Rivaroxaban works by binding to the blood clot factor, and this ultimately reduces the formation of fibrin and makes blood less likely to clot.
Dosage of drugs Xarelto 10mg
Usual adult dose for deep vein thrombosis (relapse)
- Recommended dose: 10 mg orally once a day
- Use: Reduce the risk of recurrent deep vein thrombosis (DVT) and / or pulmonary embolism (PE) in patients at risk of relapse of DVT and / or PE after at least 6 months of standard anticoagulant treatment .
Usual Adult Dose for Pulmonary embolism (relapse)
- Recommended dose: 10 mg orally once a day
- Use: Reduce the risk of recurrent deep vein thrombosis (DVT) and / or pulmonary embolism (PE) in patients at risk of relapse of DVT and / or PE after at least 6 months of standard anticoagulant treatment .
Usual adult dose for prophylaxis of deep vein thrombosis after surgery
- Initial dose: 10 mg orally once a day starting 6 to 10 hours after surgery
Duration of treatment
- Hip replacement surgery: 35 days
- Knee replacement surgery: 12 days
Contraindications to drugs xarelto 10mg Rivaroxaban
- Hypersensitivity to the active substance or to any of the drug excipients.
- There are currently any serious bleeding.
- Are there any conditions that increase the risk of bleeding, such as stomach ulcers or some types of cancer.
- Recently had surgery on your brain, spine or eyes.
- Are taking other blood thinners to treat or prevent blood clots, such as warfarin or heparin.
- There are liver and kidney problems.
- There are artificial heart valves.
- Being pregnant: you need to use an effective contraceptive method to prevent pregnancy while taking Rivaroxaban, as it can harm a developing baby.
- are breastfeeding: if you need treatment with Rivaroxaban, you should not breastfeed because we do not know whether the drug will pass into breast milk.
Side effects of Xarelto
- Like other similar drugs (antithrombotic drugs), Xarelto can cause life-threatening bleeding. Excessive bleeding can lead to a sudden drop in blood pressure (shock).
- Bleeding may also be a sign of side effects. In some cases, bleeding may not be obvious
Notify your doctor immediately, if you experience any of the following side effects:
- long or excessive bleeding
- Special weakness, fatigue, pallor, dizziness, headache, unexplained swelling, difficulty breathing, chest pain or angina, which may be a sign of bleeding.
Your doctor may decide to keep you under closer observation or change the way you should be treated.
Signs of serious skin reaction
- widespread skin rash, blisters or mucosal lesions, e.g. in the mouth or eyes (Stevens-Johnson syndrome / toxic epidermal necrolysis) The frequency of this side effect is very rare (up to 1 in 10,000).
- a drug reaction that causes a rash, fever, inflammation of internal organs, hematologic abnormalities and systemic diseases (DRESS syndrome). The frequency of this side effect is very rare (up to 1 in 10,000).
Signs of serious allergy
- Swelling of the face, lips, mouth, tongue or throat; Difficulty swallowing; rash and shortness of breath; Sudden decrease in blood pressure.
- The frequency of these side effects is very rare (anaphylactic reaction, including anaphylaxis; may affect up to 1 in 10,000 people) and is uncommon (angioedema and allergy; may affect 1 in 100 people).
Common side effects (may affect up to 1 in 10 people)
- Reduced red blood cells can make the skin pale and cause weakness or trouble breathing
- stomach or intestinal bleeding, urogenital bleeding (including blood in urine and heavy menstrual bleeding), nose bleeds, bleeding gums
- Bleeding into the eye (including bleeding from the eye white)
- bleeding into tissue or cavities of the body (hematoma, bruising)
- hemoptisi
- Bleeding from the skin or under the skin
- bleeding after surgery
- bleeding or fluid from surgical wounds
- swelling in limbs
- pain in the limbs
- Impaired renal function
- fever
- Stomach pain, indigestion, feeling or sickness, constipation, diarrhea
- low blood pressure (symptoms may feel dizzy or faint when standing up)
- Decreased general strength and energy (weakness, fatigue), headache, dizziness
- rash, itchy skin
- Blood tests may show an increase in certain liver enzymes
Uncommon side effects (may affect up to 1 in 100 people)
- Bleeding into the brain or inside the skull
- Bleeding into joints causes pain and swelling
- Thrombocytopenia (low platelet count, cells that help blood to clot)
- Allergic reactions, including allergic skin reactions
- Impaired liver function (may be seen in tests done by your doctor)
- Blood tests may show an increase in bilirubin, some liver or liver enzymes or platelet counts
- fainting
- not feeling well
- faster heart rate
- Dry mouth
- hive
Rare side effects (may affect up to 1 in 1,000 people)
- Bleeding into muscles
- Cholestasis (decreased bile flow), hepatitis included. Liver cell damage (inflamed liver including liver damage)
- Jaundice (swelling of the skin and eyes) is local
- Blood clot (hematoma) in the groin as a complication of the heart procedure where the catheter is placed in your leg artery (pseudoaneurysm)
If you receive any of these side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.
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Other drug interactions with Xarelto
- It is important to tell your doctor or pharmacist about the medicines you are taking, including medicines bought without a prescription and herbal medicine, before you start taking Xarelto medicine.
- Check with your doctor or pharmacist before taking any new medication after you start taking Xarelto, to make sure this combination is safe. Some key points are:
Analgesic
- Do not use over-the-counter painkillers, anti-inflammatory or cold and flu medicines containing aspirin, ibuprofen or naproxen while you are taking Xarelto.
- These drugs should only be used on doctor’s advice because they may increase the risk of bleeding.
Herbal
- Do not use St. John’s herbal medicine (Hypericum perforatum) while you are taking Rivaroxaban, as it can make Rivaroxaban less effective in preventing blood clots.
Preserving the drug Xarelto
- Store at room temperature below 30 ° C.
- Store in a dry place, do not store in the bathroom.
- Keep all medicines in a safe place, out of reach of children and pets.
Source: index-china.com
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Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Medical Certificate:
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.
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