Venclexta 100mg Venetoclax medicine to treat blood cancer. You need to know how much Venetoclax costs? You do not know where Venclexta is sold?
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Basic information about Venclexta 10mg 50mg 100mg Venetoclax for blood cancer treatment
- Brand name: Venclexta
- Active ingredient: Venetoclax
- Content: 10mg, 50mg, 100mg
- Form: tablets
- Manufacturer: Abbvie & Genentech
- Venclexta Prices: COMMENT below for prices OR Click on the link: https://thuoclp.com/chatFB type “Venclexta”
What is Venclexta? Indications for treatment of Venetoclax?
Venetoclax inhibits a certain protein in cancer cells (abnormal lymphocytes produced in chronic lymphocytic leukemia) that help keep those cells alive and make them resistant to chemotherapy. Venetoclax binds to this protein to help kill cancerous lymphocytes in the blood and bone marrow.
Venetoclax is sometimes used with another medicine called rituximab.
Venetoclax is usually given after other treatments have failed.
Venclexta is indicated for treatment:
For treatment of adult patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
In combination with low-dose azacitidine or decitabine or cytarabine to treat newly diagnosed acute myeloid leukemia (AML) in adults:
- From 75 years of age or older
- Having comorbid conditions prevents the use of intensive induction chemotherapy.
This sign is approved under acceleration approval based on the response rate. Further approval for this designation may depend on verification and description of clinical benefits in validation trials.
The mechanism of action of Venetoclax
Venetoclax contains an anti-apoptotic protein that inhibits the activity of B-cell lymphoma-2 protein (BCL-2 protein).
The BCL-2 protein is often highly expressed in CLL cells, where it blocks the apoptosis process of lymphocytes and also makes them resistant to chemotherapy. Venclexta binds to BCL-2 protein to replace prooptotic proteins like BIM and activate mitochondrial membrane permutation and programmed caspase activation and cell death. In non-clinical studies, Venetoclax has demonstrated cytotoxic activity in tumor cells overexpressing BCL-2.
Contraindicated
- Do not use Venclexta in patients with any component of this drug.
- Do not use Venclexta for pregnant and lactating women, due to the risk of harm to the fetus and the baby.
- Concomitant use of Venclexta with strong CYP3A inhibitors at the beginning and in the period of intensification is contraindicated in patients with CLL / SLL due to the increased risk of tumor lysis syndrome (TLS).
Dosage and usage Venclexta
Dosage recommended
You will begin treatment with Venclyxto with a low dose for 1 week. The doctor will gradually increase the dose over the next 4 weeks with the full standard dose. For the first 4 weeks, you will receive a new dose every week.
- The starting dose is 20 mg once daily for 7 days.
- The dose will be increased to 50 mg once daily for 7 days.
- The dose will be increased to 100 mg once daily for 7 days.
- The dose will be increased to 200 mg once daily for 7 days.
- The dose will be increased to 400 mg once daily for 7 days.
When you are on Venclyxto alone, you will maintain the 400 mg daily dose, which is the standard dose as long as necessary.
When you are on Venclyxto in combination with rituximab, you will receive a dose of 400 mg daily for 24 months.
Using
Take Venclexta immediately after meals and water, at the same time each day.
Do not crush, chew or break a Venclexta tablet. Swallow whole tablets.
During the first 5 weeks of treatment, you should take your medication in the morning to help you monitor your blood tests, if needed.
To prevent certain side effects, drink 6 to 8 glasses of water daily for 2 days before you start taking venetoclax. Also drink 6 to 8 glasses of water on the first day you drink Venclexta and whenever your dose changes.
Warnings and precautions when using Venclexta
Tumor lysis syndrome (TLS): TLS is caused by the rapid disruption of cancer cells. TLS can cause kidney failure, require dialysis and can lead to death.
Low white blood cell count: Using Venclexta causes a decrease in the number of white blood cells and can make the condition worse.
Infections: death and serious infections such as pneumonia and sepsis have occurred during treatment with Venclexta.
Liver and kidney function: The effect of liver and kidney function on the way this drug works has not been determined. Decreased liver and kidney function may increase the likelihood of side effects of venetoclax.
Other cancers: Taking Venclexta may increase your risk of developing skin cancer. Report any unusual growth on your skin or change the growth on your skin with your doctor as soon as possible.
Fertility: This drug can cause low or no sperm production when used by men. This may affect a child’s ability to father a child after taking venetoclax.
There is a problem with body salts or electrolytes, such as potassium, phosphorus or calcium.
A history of high uric acid levels in your blood or gout.
Scheduled to receive vaccines: you should not receive live vaccines before, during or after treatment with Venclexta until your doctor tells you it’s okay.
Side effects of Venclexta
The most common side effects of Venetoclax when used in combination with obinutuzumab or rituximab or alone in people with CLL or SLL include:
- Low white blood cell count
- Low platelet count
- Low red blood cell count
- Diarrhea
- Nausea
- Infections of the upper respiratory tract
- Ho
- Muscle and joint pain
- Tired
- Swelling of hands and feet
The most common side effects of Venetoclax in combination with low-dose azacitidine or decitabine or cytarabine in people with AML include:
- Low white blood cell count
- Nausea
- Diarrhea
- Low platelet count
- Constipation
- Fever with low white blood cell count
- Low red blood cell count
- Infection in the blood
- Rash
- Dizzy
- Low blood pressure
- Fever
- Swelling of hands and feet
- vomiting
- Tired
- Shortness of breath
- Bleeding
- Infections in the lungs
- Stomach pain
- Pain in the muscles or back
- Ho
- Sore throat
Other drug interactions with Venclexta
- Concomitant use with strong or moderate CYP3A inhibitors or P-gp inhibitors that increase Venclexta exposure may increase Venclexta toxicity, including TLS risk.
- Monitor international standardization rate (INR) closely in patients taking warfarin.
Food interaction
Do not drink grapefruit juice or eat grapefruit, Seville oranges or starfruit while you are taking Venclexta. These products can increase the amount of Venclexta in your blood.
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Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Medical Certificate:
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.
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