Drug information Velpanex for hepatitis C
- Brand Name: Velpanex .
- Active ingredients: sofosbuvir & velpatasvir .
- Manufacturer: Everest.
- Content: 400mg & 100mg.
- Form: Tablets.
- Packing: vial of 28 Tablets.
What is Velpanex?
Velpanex medicine contains Active ingredients sofosbuvir and velpatasvir. The drug helps reduce the amount of hepatitis C virus (HCV) in the body, helps the patient’s immune system work better, fights infections and enhances liver function.
How does Velpanex active ingredient work?
Active ingredient sofosbuvir is a pan genotype inhibitor of HCV NS5B RNA-dependent RNA polymerase, which is required for viral replication.
Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), which can be incorporated into HCV RNA by NS5B polymerase and acts as a terminator. Chain.
GS-461203 (active metabolite of sofosbuvir) is not an inhibitor of human DNA and RNA polymerase nor an inhibitor of mitochondrial RNA polymerase.
The active ingredient velpatasvir is an HCV inhibitor that targets the HCV NS5A protein, which is required for both RNA replication and assembly of HCV virions.
Selection and cross-resistance studies in vitro suggest that velpatasvir targets NS5A as its mode of action.
What is Velpanex used for?
- Velpanex combination Sofosbuvir 400mg and Velpatasvir 100mg is indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5 or 6 infection.
- Patients without cirrhosis or with compensated cirrhosis.
- In patients with decompensated cirrhosis, use in combination with Ribavirin.
- Patients infected with hepatitis C virus.
Who should not take Velpanex?
- Hypersensitivity to the active substance or to any of the excipients of Velpanex.
- Use with strong P-gp and strong CYP inducers.
- Drug products that are potent inducers of P-glycoprotein (P-gp) or cytochrome P450 (CYP) (carbamazepine, phenobarbital, phenytoin, rifampicin, rifabutin).
Dosage and how to use Velpanex drug?
Dosage of the drug
The recommended dose is 1 tablet per day.
For patients without cirrhosis and patients with compensated cirrhosis: 1 tablet per day, continuously for 12 weeks.
For patients with decompensated cirrhosis: one tablet once daily and ribavirin administered for 12 weeks. The recommended dosage of Ribavirin is based on body weight (1000mg/day for patients <75 kg and 1200mg/day for ≥75 kg, in two divided doses).
How to use the drug?
- Velpanex is usually taken once daily for 12 weeks.
- You should not stop using the medicine suddenly.
- Use all medications as directed and read all medication instructions you receive.
- If you have ever had hepatitis B, using sofosbuvir and velpatasvir can cause the virus to become active or worse.
What to do in case of overdose?
- Call 911 immediately or go to the nearest local health station.
- Of course, you’ll need to keep a record and bring a list of all the medications you’ve taken, including prescription and over-the-counter drugs.
What should I do if I miss a dose?
- If you forget to take a dose, take it as soon as possible.
- But if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time.
- Do not take double the prescribed dose.
Precautions while you are taking Velpanex
You should not use Velpanex if you are allergic to sofosbuvir or velpatasvir. To make sure the medicine is safe for you, tell your treating doctor if you have ever:
- Hepatitis B;
- HIV (human immunodeficiency virus);
While taking Velpanex together with ribavirin, use at least 2 effective forms of birth control to prevent pregnancy, whether you are male or female.
Continue using 2 forms of birth control for at least 6 months after your last dose of ribavirinin
Effects on pregnant or lactating women
There are no adequate human data available to establish whether or not the combination of Sofosbuvir and Velpatasvir poses a risk for pregnancy outcomes.
If Velpanex is combined with Ribavirin, the combination regimen is contraindicated in pregnant women and in men whose partners are pregnant or are pregnant for the next six months.
Velpanex side effects
The most common side effects of the Velpanex drug combination include headache and fatigue. Treatment may lead to bradycardia along with other symptoms when taken with amiodarone. The drug when combined with Ribavirin will have side effects of the drug Ribavirin during treatment.
Common side effects are:
- Headache and fatigue.
- Slowing heart rate along with other symptoms when taken with amiodarone (a medicine used to treat certain heart problems).
What other drugs may interact with Velpanex?
- The drug may decrease the concentration of sofosbuvir or velpatasvir. Antacids, H2 receptor antagonists, proton pump inhibitors, etc.
- Concomitant use is not recommended with: topotecan, carbamazepine , Phenytoin, Phenobarbital, Oxcarbazepine, Rifabutin, Rifampin, Rifapentine, efavirenz, Tipranavir, Ritonavir, Hypericum perforatum.
- Co-administration of Sofosbuvir and Velpatasvir with Rosuvastatin, Atorvastatin may significantly increase concentrations of Rosuvastatin, Atorvastatin.
How much does Velpanex cost? Buy Velpanex pills
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How to store medicine?
- You should store the medicine at room temperature, in a cool, dry place, away from direct sunlight.
- You should not store the medicine in the refrigerator.
- Keep the medicine out of the reach of children.
- Do not throw medicine down the toilet or plumbing.
The above article is for reference only and is not a substitute for medical diagnosis or treatment. Readers should only follow the instructions of the doctor who is treating you, Index-China disclaims responsibility if problems occur.
Reputable source ThuocLP Vietnamese: Velpanex medicine for hepatitis C: dosage, drug price
Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.