Drug information Velpaclear treatment of hepatitis C
- Brand Name: Velpaclear .
- Active ingredients: Velpatasvir and Sofosbuvir.
- Manufacturer: Abbott India.
- Strength: 100mg and 400mg.
- Form: Tablets.
- Packaging: Box of 28 tablets.
What is Velpaclear?
Velpaclear medicine manufactured by Abbott, is a fixed dose combination of Sofosbuvir 400mg and Velpatasvir 100mg tablets. This is a prescription drug that can only be obtained by a patient with a valid prescription from a healthcare professional.
Do not share this hepatitis medicine with others because it can cause serious side effects for the patient until the condition is not monitored by the pharmacist.
Drug operation mechanism Velpaclear like?
The drug is a direct-acting antiviral (DAA) drug. DAAs are a class of drugs that directly block the hepatitis C virus’s ability to make copies. These drugs work by weakening the action of proteins needed for hepatitis C.
One of the two drugs in Velpaclear is Sofosbuvir, which is a nucleotide polymerase inhibitor, and the other is Velpatasvir, which is an NS5A (hepatitis C virus non-structural protein 5A) inhibitor. Sofosbuvir interferes with the reproduction of the hepatitis C virus’s genetic material.
Velpatasvir works by interfering with a protein needed by the virus. These two drugs together greatly reduce and then stop the production of new copies of the hepatitis C virus.
What is Velpaclear used for?
Velpaclear is an antiviral medicine used to treat chronic hepatitis C virus (HCV) infection, including all six major HCV genotypes.
Who should not take the drug?
- Velpaclear is indicated for the treatment of adult patients with chronic hepatitis C, genotype 1,2,3,4,5 or 6.
- No cirrhosis : Treatment period of 3 months with 3 boxes of medicine.
- Compensated cirrhosis: Treatment for 3 months with 3 boxes of medicine.
- Decompensated cirrhosis: Combination therapy with Ribavin for 3 or 6 months
Some notes before you start taking Velpaclear
The drug is contraindicated in cases of allergy to sofobuvir, velpatasvir and other excipients of the drug.
Before treatment, you must inform your doctor about your health status, including diseases you have had, are having and suspected of having. If you have the following health problems, pay special attention:
- HIV virus infection.
- Hepatitis B, C or other liver problems.
- Have kidney, pancreas, lung problems.
- Stomach problems.
- Problems with endocrine glands.
Dosage and how to use Velpaclear?
Dosage of Velpaclear
The recommended dose of Velpaclear is one tablet taken orally, once daily with or without food.
Drugs to be treated and duration for all HCV genotypes
When taken with the drug, the recommended dosage of ribavirin is based on weight (taken with food).
1000 mg daily for patients less than 75 kg and 1200 mg for those weighing at least 75 kg, taken twice daily.
The dose of ribavirin may be adjusted based on hemoglobin and creatinine clearance. For ribavirin dose adjustments, refer to the ribavirin prescribing information.
Patients without cirrhosis and patients with compensated cirrhosis: Drugs for 12 weeks.
Patients with decompensated cirrhosis: Velpaclear + ribavirin for 12 weeks or 24 weeks.
How to use Velpaclear?
- Take this medicine at the dose and duration advised by your doctor.
- Swallow it as a whole. Do not chew, crush or break it.
- Velpaclear can be taken with or without food, but it is better to take it at a fixed time.
- Do not miss your dose and always try to take it at the fixed time possible. In case you miss a dose and it is time for your next dose, instead of taking an overdose, take the next dose. Do not take 2 or more doses at the same time. Do not change the dose or stop the medication without consulting your doctor.
Velpaclear side effects
A side effect is an unwanted effect of a drug. Medicines can have some side effects, but not everyone experiences them. When you take Velpaclear, it is important to understand the side effects you may experience from this hepatitis medicine.
The following is a list of possible side-effects that may occur in medicines that contain Velpatasvir & Sofosbuvir:
Common side effects: fatigue, headache, diarrhea, loss of appetite, fatigue, rash, trouble sleeping, lack or loss of strength, difficulty concentrating, loss of interest or pleasure. angry, frustrated.
Serious side effects: chest pain or discomfort, shortness of breath, slow or irregular heartbeat, dizziness or fainting, fatigue.
These are not all possible side effects of this hepatitis medicine. To learn more about the possible side effects of Velpatasvir 100 mg & Sofosbuvir 400 mg, read the label or leaflet or talk to your healthcare provider.
What drugs interact with Velpaclear?
Using more than one drug at the same time can change the effectiveness of the drug, increasing the risk of treatment. Therefore, tell your doctor about all the medicines you are taking, including prescription, over-the-counter, vitamins, herbs, supplements, etc.
Below we list only some of the drugs that may interact with this drug. Please consult your doctor for more details
- Anti-cancer drugs such as hycampin, topotecan, etc.
- HIV drugs such as efavirenz, emtricitabine, tenofovir …
- TB drugs such as myconbutin, prifin, rifater…
- Epilepsy drugs such as rileptal, dilantin, etc.
- Drugs that lower cholesterol levels such as rosuvastatin…
Interaction with alcohol
It is not clear if Velpaclear has any reactions to alcohol. Please consult your doctor.
For pregnant women
The drug is POSSIBLY SAFE if taken during pregnancy. There are very few human studies but animal studies have shown no adverse effects on the baby. However, you should consult your doctor before taking the drug.
It is not known whether Velpaclear will harm breast milk. Please consult your doctor.
It is not clear if the drug will affect your ability to drive. Please consult your doctor.
For patients with kidney problems
It is not clear whether the drug causes any side effects in patients with kidney disease. Please consult your doctor.
For patients with liver disease
Velpaclear is POSSIBLY SAFE if you have liver disease. However, you should consult your doctor if you have any liver problems before taking the medicine.
How much does Velpaclear cost? Buy Velpaclear medicine
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Medication storage instructions
- Store it in a cool and dry place. Improper storage can affect the effectiveness and shelf life of the medicine.
- Keep Velpaclear in the original bottle with the attached label and tightly close the childproof cap.
- If you’re driving, you may want to have some medications on hand, but don’t store them in the glove compartment, where they can be damaged by heat, cold, or rain outside or from heaters or air conditioners. of the car.
- Keep this hepatitis medicine in a well-lit place so you can always read the label and take the correct dose.
- Keep your medication separate from that of your spouse or other family members. This will make you less likely to get things wrong by mistake.
The above article is for reference only and is not a substitute for medical diagnosis or treatment. Readers should only follow the instructions of the doctor who is treating you, Index-China disclaims responsibility if problems occur.
Reputable source ThuocLP Vietnamese: Velpaclear medicine 400/100mg Sofosbuvir and Velpatasvir treat hepatitis C
Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.