Tofacinix 5mg Tofacitinib anti-rheumatoid drugs (rheumatoid arthritis). You need to know how much does Tofacitinib cost? You do not know where Tofacinix is sold? index-china is the address of Tofacinix medicine trading in Ho Chi Minh City, Hanoi, Da Nang, Can Tho … and nationwide.
Tofacinix medicine 5mg Tofacitinib treatment for rheumatoid arthritis
- Brand name: Tofacinix
- Active ingredient: Tofacitinib
- Content: 5mg
- Form: Tablets
- Package: 1 box of 30 tablets
- Manufacturer: Beacon Pharmaceuticals Limited
- Tofacinix Drug Prices: COMMENT below for prices OR Click on the link: https://thuoclp.com/chatFB type “Tofacinix”
Indications for treatment of Tofacinix
Tofacinix is used for long-term treatment. Most people who benefit from this treatment will notice an improvement within four weeks after starting treatment but further improvements can be seen during the first six months of treatment.
- Tofacinix is indicated for the treatment of patients with moderate to severe active rheumatoid arthritis who respond to inadequate or intolerance to methotrexate.
- Tofacinix is also used to treat adults with moderate to severe ulcerative colitis. Extended-release tofacinix (XR) is not used in the treatment of ulcerative colitis.
Tofacinix can be used as monotherapy or in combination with methotrexate or non-biologically altered anti-arthritis drugs (DMARDs).
The mechanism of action of Tofacitinib
- Tofacitinib is a Janus kinase inhibitor (JAK). JAK is the intracellular enzyme signaling arising from cytokine or receptor growth factor growth on cell membranes that influence the cell process of hematopoiesis and immune cell function.
- In the signaling pathway, JAKs phosphorylate activate the transducer signal and transcription activator (STAT) modulates intracellular activity including gene expression. Tofacitinib modulates the signaling pathway at the point of the JAK, prevents phosphorylation and activates STATs. JAK enzyme is paired with JAK (for example: JAK1 / JAK3, JAK1 / JAK2, JAK1 / TyK2, JAK2 / JAK2) that provide cytokine signals.
- Tofacinix inhibits JAK1 / JAK2 in in vitro activity of JAK1 / JAK3 and JAK2 / JAK2 combination of enzymes, 50 microchips are 406.56 and 1377 nM. But specifically the association of JAK conjugate enzyme with therapeutic effect has not been established.
Contraindicated
- Pregnant and lactating women.
- Allergy to the ingredients contained in the drug Tofanix.
Dosage and usage of Tofacinix
Dosage recommended
Tofacinix may be used in combination with methotrexate or other non-biological DMARD drugs
- The recommended dose of Tofacitinib is 5 mg twice daily
- The recommended Tofacitinib dose with Extended Release Formula (XR) is 11 mg per day.
Switch from Tofacitinib 5mg tablets to Tofacitinib XR 11mg tablets
- Patients treated with Tofacitinib 5 mg twice daily may be switched to Tofacitinib 11 mg once daily after the last dose of Tofacitinib 5 mg
If there is a serious infection, a decrease in blood cells, drug interactions, damage to kidney or liver function, etc., dose adjustment is necessary.
Using
- Tofacinix is used 2 times a day (10mg), each time 5mg.
- Tofacinix is taken orally, before or after meals.
- Do not break, crush, or chew Tofacinix tablets.
Warnings and precautions when using Tofacinix
Avoid using Tofacitinib in patients with severe, positive infections including local infections. The risks and benefits of treatment should be considered before starting tofacitinib in patients:
- Have a chronic or recurrent infection
- People who have been exposed to tuberculosis
- History of serious infection or opportunistic infection
- People who have resided or traveled in areas of endemic tuberculosis or endemic mycoses
- With basic conditions can make them infected
Reporting malignant and lymphoproliferative tumor disorders, malignancies that have been observed in clinical studies include unlimited: lung cancer, breast cancer, prostate cancer and pancreatic cancer. .
Perforation of the gastrointestinal tract (GI) has been reported, but the role of JAK inhibitors in these events is unclear; patients at risk of perforation of the gastrointestinal tract (e.g., diverticulitis) should be used. careful.
Concerning a gradual reduction in the number of lymphocytes and neutrophils and hemoglobin levels may need to be discontinued.
Elevated blood lipids: treatment with tofacinix may increase blood lipid parameters including: total cholesterol, low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol.
Not recommended for severe liver damage.
Report of reactivation of the virus, including cases of reactivation of the herpes virus (e.g. herpes zoster).
Reporting non-melanoma skin cancer (NMSCs), patients with an increased risk of skin cancer should have regular skin tests.
Dosage may need to be reduced for moderate to severe hepatic or renal impairment.
Be careful when treating diabetics, it is often reported that the infection rate in diabetics is higher.
Side effects of Tofacinix
- Systemic infection
- Headache
- Diarrhea
- Stuffy nose, sore throat and runny nose (sore throat)
- High Blood Pressure
Tell your doctor if you have any side effects or persist that does not go away.
Other drug interactions with Tofacinix
- Strong CYP3A4 induction may reduce clinical response
- If combined with strong or moderate CYP3A4 inhibitors plus CYP2C19 inhibitors, increasing Tofacinix poses a higher risk of side effects, dose reduction is needed.
- Avoid use with live virus vaccines
- When Tofacitinib is used together with strong immunosuppressant drugs (such as azathioprine, tacrolimus, cyclosporin) will increase the risk of immunosuppression. Tofacinix is not recommended with biological DMARD or potent immunosuppressants.
Preserving the drug Tofacinix
- Store the medicine in a dry place, away from direct light.
- Keep out of reach of children and pets.
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Note: Information about the article about Tofacinix 5mg Tofacitinib drug for the purpose of sharing reference knowledge, patients are not allowed to use the drug on their own, all information on drug use must be directed to a qualified physician.
Source: index-china.com
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