What is Tagrisso 80mg Osimertinib?
Tagrisso medicine contains the active ingredient osimertinib which is a cancer medicine that interferes with the growth and spread of cancer cells in the body. The drug is used to treat a type of non-small cell lung cancer . This medicine is used only if your tumor has a specific genetic marker.
Drug information Tagrisso 80mg Osimertinib treatment of late stage lung cancer
- Brand Name: Tagrisso.
- Active ingredient: Osimertinib .
- Manufacturer: Astrazeneca.
- Content: 80mg.
- Packaging: Box of 30 tablets.
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What is the mechanism of action of osimertinib?
Active ingredient Osimertinib is a Tyrosine Kinase inhibitor (TKI). It is an irreversible inhibitor of epidermal growth factor receptors (EGFRs) containing the susceptibility mutation (EGFRm) and the TKI resistance mutation T790M.
What is tagrisso used for?
Treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) by activating epidermal growth factor (EGFR) mutations.
Treatment of adult patients with EGFR T790M mutation-positive or metastatic NSCLC.
Who should not take the drug?
- Hypersensitivity to the active substance osimertinib or to any of the excipients.
- St. John’s Wort should not be used together with Tagrisso.
Dosage and how to use Tagrisso drug?
Dosage of Tagrisso 80mg
Recommended dose: 80mg once daily until disease progression or unacceptable toxicity.
Dose interruption or reduction of Tagrisso may be necessary based on individual safety and tolerability. If dose reduction is necessary, then the dose should be reduced to 40 mg once daily.
Note: Intensity of clinical adverse events classified according to the National Cancer Institute (NCI) Common Adverse Events (CTCAE) criteria.
No dose adjustment is necessary due to patient age, body weight, sex, ethnicity and smoking status.
No dose adjustment is recommended in patients with mild hepatic impairment (total bilirubin ≤upper normal (ULN) and aspartate aminotransferase (AST) > ULN or total bilirubin > 1.0 to 1.5x ULN and any AST) or moderate hepatic (total bilirubin 1.5 to 3 times ULN and any AST) but caution should be exercised when TAGRISSO is administered to these patients.
The safety and effectiveness of this medicinal product have not been established in patients with severe hepatic impairment. Until additional data become available, use in patients with severe hepatic impairment is not recommended
No dose adjustment is recommended in patients with mild, moderate, or severe renal impairment. Limited data are available in patients with severe renal impairment.
The safety and effectiveness of this medicinal product have not been established in patients with end-stage renal disease [creatinine clearance (CLcr) <15 ml/min, calculated according to the Cockcroft and Gault formula], or hemodialysis. Caution should be exercised when treating patients with severe and end-stage renal failure
The safety and effectiveness of Tagrisso in children or adolescents under the age of 18 years have not been established. No data available.
How to take Tagrisso 80mg
Tagrisso is intended for oral use. The tablet should be swallowed whole with water and it should not be crushed, split or chewed.
If the patient cannot swallow the tablet, it can be broken down with 50ml of water.
If nasogastric tube infusion is necessary, the same process as above should be followed but using a volume of 15 ml for initial dispersal and 15 ml for rinsing.
The medicine is usually taken once per day.
What to do in case of an overdose of Tagrisso?
Call 911 immediately or go to the nearest local health station.
Of course, you’ll need to keep a record and bring a list of all the medications you’ve taken, including prescription and over-the-counter drugs.
What should I do if I miss a dose?
If you forget to take a dose, take it as soon as possible.
But if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time.
Do not take double the prescribed dose.
Precautions while you are taking Tagrisso
You should not use Tagrisso if you are allergic to osimertinib. To make sure the medicine is safe for you, tell your doctor if you have:
- Respiratory disorders;
- Electrolyte imbalances (such as high or low levels of calcium, potassium, or magnesium in your blood);
Heart rhythm disturbances;
Tagrisso can harm an unborn baby or cause birth defects. Do not use if you are pregnant, and tell your doctor right away if you become pregnant. Use effective birth control while you are using this medicine and for at least 6 weeks after your last dose.
For men should use birth control while using the pill and for at least 4 months after you finish treatment, the baby may have birth defects.
Tagrisso may affect fertility (ability to have children), whether you are a man or a woman. However, you should use recommended birth control during and after drug treatment.
Tagrisso side effects
Get emergency medical help if you have signs of an allergic reaction to Tagrisso: hives; shortness of breath; swelling of the face, lips, tongue, or throat.
Call your doctor right away if you have:
- Shortness of breath;
- Feeling dizzy;
- Rapid weight gain;
- new or worsening lung symptoms: sudden chest pain or discomfort, wheezing, dry cough, feeling short of breath;
- Eye problems: vision changes, watery eyes, increased sensitivity to light, eye pain or redness.
- Common side effects may include: diarrhea, feeling tired, dry skin, rash, infection, or other problems with your fingernails or toenails.
Drug interactions with Tagrisso 80mg Osimertinib
Many drugs can interact with the active ingredient osimertinib . Not all interactions may be listed here. Tell your doctor about all of your current medicines and any you start or stop using, especially:
- Cancer drugs;
- An antibiotic or antifungal medicine;
- Antiretroviral drugs to treat hepatitis or HIV/AIDS;
- Heart or blood pressure medication;
- Medicines to treat a mental disorder;
- Seizure medication;
- Tuberculosis medicine.
This list is not complete and many other drugs may interact with Tagrisso. Give a list of all your medicines to any health care provider who treats you.
How much does Tagrisso cost? Buy Tagrisso
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The above article is for reference only and is not a substitute for medical diagnosis or treatment. Readers should only follow the instructions of the doctor who is treating you, Thuoclp Vietnamese Health disclaims responsibility if problems occur.
Reputable source ThuocLP Vietnamese: Tagrisso drug 80mg Osimertinib treats lung cancer ung
Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.