How much do you need to know about the price of Stivarga 40mg regorafenib to treat colorectal cancer? You do not know where regorafenib 40mg is sold? index-china is a trading site for Stivarga 40mg regorafenib in Ho Chi Minh City, Hanoi, Danang, Can Tho … and nationwide. Indications for the treatment of patients with colon cancer, metastases that have been previously treated, or not considered as candidates for fluoropyrimidine-based chemotherapy, an anti-VEGF therapy, and if wild KRAS, a therapy anti EGFR.
Stivarga medicine 40mg regorafenib treatment of colorectal cancer and liver cancer
- Brand name: Stivarga 40mg
- Active ingredient: Regorafenib
- Manufacturer : Bayer Germany
- Content: 40 mg
- Package: Box of 84 tablets in 3 vials, 28 vials each
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What is Stivarga? What medication is regorafenib ?
- Stivarga (regorafenib) is a cancer medicine that hinders the growth and spread of cancer cells in the body.
- Stivarga is used to treat colorectal cancer and liver cancer . It is also used to treat a rare type of tumor that can affect the esophagus, stomach, or intestines.
- Stivarga is usually given after other cancer drugs have been tried without success.
Assign stivarga drug
- Treatment of patients with colon cancer, metastases previously treated, or not considered as a candidate for fluoropyrimidine-based chemotherapy, a VEGF-resistant therapy, and if wild KRAS, an anti-EGFR therapy .
- Treatment of previously treated GI buffer patients with kinase / 2 tyrosine inhibition.
- Treatment of liver cancer patients, metastases have been previously treated
Dosage of Stivarga 40mg Regorafenib
Usual adult dosage for colorectal cancer:
- Initial dose: 160 mg (four 40 mg) orally once daily for the first 21 days of each 28-day cycle.
- Duration of treatment: Continue treatment until disease progression or unacceptable intoxication.
Usual Adult Dose for Tumor Tumor Digestion
- Initial dose: 160 mg (four 40 mg) orally once daily for the first 21 days of each 28-day cycle.
- Duration of treatment: Continue treatment until disease progression or unacceptable intoxication.
Usual Adult Dose for Liver Cancer:
- Initial dose: 160 mg (four 40 mg) orally once daily for the first 21 days of each 28-day cycle.
- Duration of treatment: Continue treatment until disease progression or unacceptable intoxication.
What happens if I miss a dose?
- Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose.
- Do not take a double dose with a forgotten dose.
What should you do if you miss a dose?
- If you forget to take a dose, take it as soon as possible. However, if it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take twice the prescribed dose.
- Because you will be appointed and monitored by your doctor, pharmacist or other health professional when using the drug, an overdose is unlikely.
How should i take Stivarga?
- Take Stivarga exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
- Stivarga is usually taken daily for 3 weeks followed by 1 week off. Your doctor will decide how many times you should repeat this treatment cycle.
- Stivarga works best if you take it after a little fat, low calorie flour. Swallow whole tablet with a full glass of water.
- Take the medicine at the same time every day.
- While using this medicine, your blood pressure will need to be checked often and you may need frequent blood tests.
- If you need surgery, tell the surgeon ahead of time that you are using regorafenib. You may need to stop using the medication for a short time.
- Store at room temperature away from moisture and heat. Keep the medication in their original packaging, along with the package or small container of moisturizing absorption preservatives. Do not put Stivarga tablets in a daily pill box.
- Throw away any unused medicine within 7 weeks after opening the bottle.

Important information before taking Stivarga
You should not use Stivarga if past use has caused serious bleeding or severe liver problems.
Stivarga can damage your liver. Stop taking this medicine and call your doctor at once if you have nausea, vomiting, trouble sleeping, dark urine, or jaundice (yellowing of the skin or eyes).
Use birth control to prevent pregnancy, whether you are a man or a woman. Contraception for at least 2 months after you stop using this medicine.
Before taking Stivarga 40mg Regorafenib
You should not use Stivarga if past use has caused serious bleeding or severe liver problems.
To make sure Stivarga is safe for you, tell your doctor if you have ever had:
- liver failure;
- High Blood Pressure;
- a bleeding or coagulation disorder;
- heart disease, chest pain; or
- if you have recently had surgery or are planning to have surgery.
Do not use Stivarga if you are pregnant. It can harm an unborn baby.
- Use birth control to prevent pregnancy while you are receiving Stivarga, whether you are a man or a woman. Tell your doctor right away if pregnancy occurs while either parent is regorafenib. Keep using birth control for at least 2 months after you finish treatment.
- It is not known whether regorafenib passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using this medication.
Will other drugs affect Stivarga?
- Sometimes it is not safe to use several medicines at the same time. Some medicines can affect your blood levels of other medicines you take, may increase side effects or make the medicine less effective.
- Many drugs may interact with regorafenib. This includes prescription and over-the-counter medications, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medications and any you start or stop using.
What drugs may interact with regorafenib?
Drug interactions can alter the ability of the drug to work or increase the effects of side effects. This document does not include the full range of possible drug interactions. It is best to write down a list of all the drugs you are taking (including prescription, over-the-counter and supplements) and show it to your doctor or pharmacist. Do not arbitrarily take, discontinue or change the dosage of the drug without a doctor’s permission.
- Anticoagulants (such as warfarin) because they may increase the risk of bleeding;
- Cobicistat, fluconazole, itraconazole, ketoconazole, macrolide antibiotics (e.g. azithromycin, clarithromycin), mifepristone, nefazodone, posaconazole, protease inhibitors (e.g. boceprevir, ritonavir), telithromycin or voriconazole because these drugs can do increased risk of side effects of regorafenib;
- Carbamazepine, enzalutamide, hydantoins (e.g. phenytoin), phenobarbital, primidone, rifamycins (eg rifampin) or St. John wort because they can reduce the effectiveness of regorafenib.
What should i avoid while taking stivarga?
- Grapefruit and grapefruit juice may interact with regorafenib and lead to potentially dangerous effects. Avoid the use of grapefruit products while taking Stivarga.
- Avoid taking an herbal supplement containing the wort of St. John at the same time you are taking Stivarga.
- This drug can pass into body fluids (urine, stool, vomit). Caregivers should wear rubber gloves when cleaning a patient’s body fluids, handling contaminated waste or washing or changing diapers. Wash hands before and after removing gloves. Wash soiled clothes and towels separately from other laundry.
Side effects Stivarga
Get emergency medical help if you have signs of an allergic reaction to Stivarga: hives; shortness of breath; swelling of face, lips, tongue, or throat.
Stop using Stivarga and call your doctor at once if you have:
- severe headache, vision problems, confusion, thinking problems;
- convulsions;
- rash, blisters, or severe pain in the palm of your hand or soles of your feet;
- heart problems – severe chest pain and dizziness, trouble breathing;
- increased blood pressure – severe headache, blurred vision, pounding in your neck or ears;
- liver problems – nausea, vomiting, difficulty sleeping, dark urine, jaundice (jaundice or eyes);
- perforation (a hole or tear) in his stomach or intestines – fever with severe abdominal pain or swelling, nausea, vomiting, increased thirst, decreased urination;
- severe bleeding – nosebleeds, heavy menstrual periods or unusual vaginal bleeding, blood in urine, bloody or tarry stools, coughing up blood, bleeding or any of which will not stop; or
- signs of infection – fever, sore throat, feeling short of breath, cough with phlegm, vaginal itching or discharge, pain or burning during urination, or redness and swelling anywhere in your body.
Your cancer treatments may be delayed or stopped permanently if you have certain side effects.
Common Stivarga side effects may include:
- diarrhea, abdominal pain, loss of appetite, weight loss;
- fever, infection;
- Abnormal liver function tests;
- sore mouth or throat, hoarse voice; or
- feeling weak or tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Source: index-china.com
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The FDA has expanded the use of stivarga to treat liver cancer
- The U.S. Food and Drug Administration (FDA) has recently expanded the use of the approved drug stivarga (regorafinib) to treat hepatocellular carcinoma (HCC) – patients who have stopped responding with initial treatment with sorafenib.
- According to the National Cancer Institute, about 40,710 people will be diagnosed with liver cancer in 2017 and about 28,920 will die from these diseases. HCC originates in the liver and is the most common form of liver cancer.
- Stivarga is a kinase inhibitor that works by blocking certain enzymes that promote cancer growth. Stivarga is also approved to treat colorectal cancer and digestive lymphomas that no longer respond to previous treatments.
- Common side effects of stivarga include stomach pain, skin reactions, fatigue, diarrhea, decreased appetite, hypertension, infection, fever, weight loss and nausea. Stivarga is associated with serious risks, including liver damage (liver toxicity), infection, severe gastrointestinal bleeding, etc.
- The FDA also said that pregnant or breast-feeding women should not take stivarga because it can harm a developing fetus or infant. Women taking stivarga should use effective contraception for 2 months after the last dose.
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Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Medical Certificate:
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.
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