Sprycel medicine 50mg Dasatinib treatment of leukemia – Price of Sprycel

Sprycel 50mg Dasatinib medicine treats leukemia (leukemia). How much do you need to know the price of Dasatinib? You do not know where Sprycel is sold? index-china is an address specializing in trading Sprycel medicine in Ho Chi Minh City, Hanoi, Da Nang, Can Tho … and nationwide.

Sprycel medicine 50mg Dasatinib treat of leukemia (blood cancer)

• Brand name: Sprycel
• Active ingredient: Dasatinib
• Content: 50mg
• Form: Tablets
• Package: 1 box of 60 tablets
• Manufacturer: Bristol – Myers Squibb

Indications for treatment of Sprycel drug

Sprycel is a drug used to treat cancer in adults with leukemia, a type of leukemia:

• Chronic myeloid leukemia (CML): diagnosed with chronic Philadelphia chromosome (Ph +) chronic bone marrow chromosome (C +) in the chronic phase (CP)
• Ph + CML no longer benefits or intolerates other treatments, including imatinib.
• Acute Ph + (Ph + ALL) lymphoblastic leukemia no longer benefit or tolerate other treatments.

Treatment in children

• Children 1 year of age and older with Ph + CML in the chronic phase or not responding to other treatments.
• Children aged 1 year and older with newly diagnosed Ph + ALL in combination with chemotherapy.

The mechanism of action of Dasatinib

• Active ingredient Dasatinib belongs to a class of drugs that block enzymes called protein kinases.
• Dasatinib works primarily by blocking the protein kinase Bcr – Abl. This enzyme is produced by leukemia cells and causes them to multiply uncontrollably. By blocking Bcr Abl kinase as well as other kinases, Sprycel helps reduce the number of leukemia cells.

Contraindicated

• Are allergic to Dasatinib or any other ingredients of this medicine.
• Do not give this medicine to a child younger than one year old.
• Pregnant and nursing women should use Sprycel.

Dosage and usage of Sprycel

Dosage recommended

• Adult patients with chronic stage CML are: 100mg once daily.
• Adult patients with CML or Ph + ALL sudden rapid growth stage are: 140mg once daily.

The dose for children with chronic CML or Ph + ALL stages is based on body weight.

• From 10 to less than 20 kg is: 40mg once daily.
• From 20 to less than 30 kg: 60mg once a day.
• From 30 to less than 45 kg: 70mg once a day.
• At least 45 kg is: 100mg once a day.

This drug should not be used for children under 10 kg.

Depending on how you respond to treatment, your doctor may adjust your dose higher or lower or even stop treatment for a short time.

Using

• Take Sprycel exactly as your doctor tells you to.
• Take Sprycel before or after a meal, at the same time each day.
• Swallow Sprycel tablets whole with water. Do not cut, crush or chew the tablet.

Warnings and precautions when using Sprycel

• Myelosuppression: treatment with Sprycel can cause severe thrombocytopenia, neutropenia and anemia.
• Bleeding: Sprycel can cause serious and fatal bleeding.
• Fluid retention : Sprycel can cause fluid retention, fluid can build up in the lining of the lungs, the sac around the heart or the stomach cavity causing serious conditions.
• Heart disease: Sprycel can cause abnormal heart rhythms and heart problems or heart attacks.
• Pulmonary hypertension (PAH): Sprycel may increase the risk of developing PAH in adult and pediatric patients, which can occur at any time during treatment.
• Severe dermatological reactions: Sprycel can cause serious dermatological reactions, including Stevens-Johnson syndrome and red rash.
• Tumor lysis syndrome (TLS): TLS is caused by the rapid disruption of cancer cells. TLS can cause you to have kidney failure and abnormal heart rhythms, often developing in patients resistant to previous imatinib therapy, mainly in advanced disease.
• Slowing growth and development in children: The effect on bone growth and development in children has occurred when taking Sprycel and can sometimes be serious.
• Embryotoxicity : Sprycel may harm an unborn baby when used in pregnant women. You should use effective contraception during treatment and for 30 days after the last dose
• Breastfeeding: Sprycel may pass into breast milk to harm a baby. You should not breastfeed during treatment and for 2 weeks after the last dose.

Side effects of Sprycel

The most common side effects in adults and children taking only Sprycel include:

• diarrhea
• headache
• skin rash
• shortness of breath
• tired
• nausea
• myalgia

The most common side effects in children taking Sprycel with chemotherapy include:

• swelling, pain and redness of the oral mucosa, throat, stomach and intestines
• Low white blood cell count with fever
• diarrhea
• nausea
• vomit
• myalgia
• stomachache
• ho
• headache
• rash
• tired
• constipation
• Abnormal heart rate
• High Blood Pressure
• swelling
• infection
• low blood pressure
• reduce appetite
• allergic reaction
• shortness of breath
• epistaxis
• numbness or tingling in hands and feet
• feel confused or disoriented

Sprycel can cause reproductive problems in men and women. Talk to your uncle before using Sprycel.

These are not all possible side effects of Sprycel. Tell your doctor if you have any other or lasting side effects that do not go away.

Other drug interactions with Sprycel

These drugs are not to be used with Sprycel:

• Ketoconazole, itraconazole: antifungal drugs
• Erythromycin, clarithromycin, telithromycin: antibiotics
• Ritonavir: antiviral drug
• Phenytoin, carbamazepine, phenobarbital: medications for epilepsy
• Rifampicin: medicine to treat tuberculosis
• Famotidine, omeprazole: drugs that prevent stomach acid
• John’s wort: an herbal preparation without a prescription, used to treat depression.

Do not take medication to neutralize stomach acids such as aluminum hydroxide or magnesium hydroxide for 2 hours before or 2 hours after taking Sprycel.

Tell your doctor if you are taking medication to thin your blood or prevent blood clots.

Food interaction

Do not drink grapefruit juice during treatment with Sprycel, which may increase your risk of serious side effects.

Preserving medicine Sprycel

• Store the medicine at room temperature between 20 ° C and 25 ° C.
• Keep this medicine out of the reach of children and pets.
• Wear rubber or nitrile gloves when handling accidentally crushed or broken tablets.
• Pregnant women should not handle crushed or broken Sprycel tablets.

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Note: Information on Sprycel 50mg Dasatinib article for the purpose of sharing knowledge for reference only, patients are not allowed to use the drug themselves, all information on drug use must be directed by a qualified physician.

Source: index-china.com

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