Sorafenat medicine 200mg Sorafenib treatment of liver and kidney cancer

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Sorafenat medicine 200mg Sorafenib treatment of liver and kidney cancer

• Generic generic name: sorafenib
• Trade name: Sorafenat
• Drug form: Bottle of 120 tablets
• Ingredients, content: Sorafenib 200mg
• Manufacturer: NATCO PHARMA
• Sorafenat Drug Prices: COMMENT below for OR Click the link: https://thuoclp.com/chatFB type “Sorafenat”

What is Sorafenat?

• Sorafenat (sorafenib) is a product used to treat advanced renal cell carcinoma and primary liver cancer.
• Sorafenat is also used to treat a type of kidney cancer called advanced renal cell carcinoma and liver cancer.
• Sorafenat is a chemotherapy drug used to treat cancer. It interferes with the growth of cancer cells and slows their growth and spread in the body.

The mechanism of action of Sorafenib

Sorafenat activity reduces tumor cell growth. Sorafenib inhibits many intracellular and kinaza cell surfaces. Enzymes that are effective against signaling, vascular and Sorafenib apoptosis
cause cancer to reduce blood flow to tumor cells

Sorafenib interferes with the intermediate genetic transcription (kinase) enzymes in cell proliferation and angiogenesis, which inhibits certain abnormal proteins that trigger cancer cell reproduction.

How to use Sorafenat

Recommended Dosage: Sorafenat 400mg (2 capsules x 200mg) should be taken twice daily for at least one hour before or two hours after a meal.

• Use Sorafenat exactly as directed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
• Administer Sorafenat on an empty stomach, at least 1 hour before or 2 hours after eating. Do not crush, chew, or break a Sorafenat tablet. Swallow it with water.
• To make sure this medication doesn’t cause harmful side effects, your blood pressure will need to be checked often. Visit your doctor often.
• If you need surgery or dentistry, tell the surgeon or dentist before you take Sorafenat. You may need to stop taking the medicine for a short time. Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed dose as soon as you remember, but at least 2 hours from your last meal. Skip the missed dose if it is almost time for your next dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

• Seek emergency medical attention or call the Poison helpline. Common symptoms may include severe diarrhea or severe skin rash.

What should i avoid while using sorafenat?

• Follow your doctor’s instructions about any restrictions on food, beverages, or activity.

Before taking Sorafenat

You should not use Sorafenat if you are allergic to sorafenib, or if you have squamous cell lung cancer and you are being treated with carboplatin (Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane).

To make sure you can safely take Sorafenat, tell your doctor if you have any of the following:

• Kidney or liver problems;
• Lung cancer;
• Blood clotting disorder or blood clotting such as hemophilia;
• High blood pressure, heart disease, tachycardia, congestive heart failure, chest pain;
• Suffering from QT syndrome;
• History of stroke or heart attack;

 Do not use Sorafenat if you are pregnant. It can harm an unborn baby. Use effective birth control while you are using this medicine and for at least 2 weeks after treatment ends, whether you are male or female. Sorafenat used by both parents can cause birth defects.

Sorafenib can pass into breast milk and may harm a nursing baby. Do not breast-feed while taking Sorafenat.

Sorafenat side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Sorafenat: rash; Shortness of breath; Swelling of the face, lips, tongue, or throat.

Stop using Sorafenat and call your doctor at once if you have serious side effects such as:

• rash, hives, vomiting, or severe pain in the palms or soles of the feet;
• Mouth sores;
• black or bloody stools, coughing up blood or vomiting;
• Pale skin, feeling light-headed or short of breath, tachycardia, difficulty concentrating
• Easy bruising, unusual bleeding in the nose, mouth, vagina, rectum, purple or red spots under the skin;
• Chest pain or severe feeling, pain spreading to arm or shoulders, nausea, sweating, feeling sick;
• Dry cough, wheezing;
• Swelling, rapid weight gain, shortness of breath;
• Numbness or sudden weakness, especially on one side of the body;
• Sudden weight loss, increased appetite, difficulty sleeping, increased bowel movement, sweating, feeling hot, feeling anxious or anxious, swollen neck;
• Dangerous high blood pressure severe headache, blurred vision, tinnitus, anxiety, confusion, irregular heartbeat, seizures;
• Dermatological reactions: severe: fever, sore throat, swelling of the face or tongue, burning eyes, skin pain, followed by a red or purple skin rash that spreads on the body and causes blistering.

Less serious Sorafenat side effects may include:

• Feeling tired;
• Nausea, vomiting, diarrhea, stomach ache, loss of appetite;
• Skin peeling or itching, slight rash;
• weight loss;
• thinning hair.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

What other drugs will affect Sorafenat?

Tell your doctor about all the other cancer drugs you use, especially cyclophosphamide (Cytoxan, Neosar), docetaxel (Taxotere), doxorubicin (adriamycin, Rubex), fluorouracil (Adrucil, Carac, Efudex, Fluoroplex), irinotecan (Camptosar), paclitaxel (Taxol) Or tamoxifen (Soltamox).

The following drugs may interact with sorafenat. Tell your doctor if you are using any of the following medicines:

• Arsenic trioxit (Trisenox);
• Bosentan (Tracleer);
• Dexamethasone (Decadron, Hexadrol);
• Montelukast (Singulair) hoặc zafirlukast (Accolate);
• Promethazine (Phenergan, Adgan, Anergan, Antinaus, Pentazine);
• Selegiline (Eldepryl, Emsam, Zelapar);
• Tacrolimus (Prograf);
• Voriconazole (Vfend);
• An antibiotic such as clarithromycin (Biaxin), levofloxacin (levaquin), neomycin (Mycifradin, Neo Fradin, Neo Tab), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate);
• Antidepressants;
• Antimalarial drugs such as chloroquine (Aralen) or mefloquine (Lariam);
• A barbiturate like pentobarbital (Nembutal);
• Blood thinners such as warfarin (Coumadin, Jantoven);
• Medicines for heart or blood pressure;
• HIV medications;
• Medicines to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol (Inapsine), ondansetron (Zofran);
• Medications to treat mental disorders like chlorpromazin (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap);
• Headache migraine drugs such as sumatriptan (Imitrex, Treximet);
• Drugs such as methadone (Methadose, Diskets, Dolophine);
• Seizure medications such as carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin);
• Thuốc sulfa (Bactrim, Gantanol, Gantrisin, Septra, SMX-TMP);
• Type 2 diabetes medications such as glimepiride (Amaryl), glipizide (Glucotrol), nateglinide (Starlix), pioglitazone (Actos, Actoplus Met), repaglinide (Prandin), rosiglitazone (Avandia, Avandamet),

This list is not complete and other drugs may interact with Sorafenat. Tell your doctor about all medicines you use.

The FDA now allows the use of Soranefib

• Patients taking Soranefib can live longer than 2.8 months compared to patients not taking this drug. Soranefib is a kinase inhibitor. Soranefib inhibits the molecules in cancer cells involved in establishing blood vessels in tumors and dead cells. The FDA allowed the use of Soranefib based on test results for 602 patients with liver cancer compared with patients not taking Soranefib. Patients on Soranefib lived 10.7 months longer than patients not on Soranefib for 7.9 months. When using Soranefib, cancer tumors progress more slowly
• Adenocarcinoma is cancer of the adenocarcinoma. In the classification of adenocarcinoma cancer, it is not necessary to originate from gland that excreted tissue like gland. Adenocarcinoma is commonly found in animals or humans.
• Recently, the “HealthDay” website in Hong Kong published the results of research on the specific drug Sorafenib which proved effective for patients with metastatic liver cancer in Asia.

Sorafenat special  medicine helps prolong life for patients with metastatic liver cancer.

• A 6-week study of 226 patients in China, South Korea and Taiwan showed that Sorafenib was able to extend the life span of patients with metastatic liver cancer.
• In 150 patients treated with the drug Sorafenib at a dose of 800 mg / day and divided into two, it was possible to survive an additional 6.5 months; the second group of 76 people who received the placebo pill only lived for 4.2 months longer.
• The drug Sorafenib is approved for use in Europe and the United States to treat metastatic liver cancer, helping to prolong life for patients. Asia-Pacific region is home to 75% of liver cancer patients in the world.

Drugs  Sorafenat: An important step forward in the treatment of kidney cancer 

• Kidney cancer (UTT) occurs most commonly in men over 60, with 85% of cases being kidney cell carcinoma, of which smoking is an important risk factor.
• In general, the prognosis of UTT to date has not been very satisfactory. But the situation will improve with the introduction of a new anti-tumor drug: sorafenib.
  Clinical manifestations of UTT include: hematuria, hip pain, abdominal tumors, fatigue, weight loss, fever, anemia … Tumors are often discovered by chance through physical examination or X-ray. Ultrasound, CT and other diagnostic imaging techniques and biopsies help distinguish benign tumors from malignant tumors, as well as identify the vascular system of the tumor and detect metastases in the liver and bones.
• If no metastatic surgical removal of the complete kidney is not recorded, the 5-year survival rate varies from 70% of the local tumor to 5% of the tumor spread further. Metastatic cancer is often resistant to hormone therapy as well as chemotherapy with only a few cases recovered after single metastases removal.
  In general, the prognosis of UTT to date has not been very satisfactory. But this will improve with the introduction of a new antitumor drug: sorafenib
• For more than a decade, this is the first time the US FDA has allowed a UTT drug to circulate in 2006. Sorafenib is indicated for the treatment of progressive kidney cell carcinoma. According to BS. Ronald Bukowsky of the Taussig Clinical Cancer Center in Ohio (Cleveland), sorafenib was the first multikinase inhibitor, targeting the kinases of serin / threonin and receptor tyrosine in both cancer cells and the vascular system of tumors. These kinases are involved in cell proliferation as well as tumor angiogenesis.
• According to the manufacturer, the sorafenib approval is based on data from the largest randomized clinical trial conducted in patients with renal cell carcinoma. Compared to placebo, sorafenib doubles the life expectancy without disease progression. A preliminary analysis showed that the drug reduced the risk of death by 28%.
• The manufacturer said serious side effects such as severe skin reactions, cardiovascular events … rarely occur below 5%. The most common side effects are: diarrhea, rash, exfoliating, tiredness, watery on hands and feet, hair loss, nausea, itching, vomiting and loss of appetite. Patients should be cautious when taking sorafenib with warfarin, doxorubin, irinotecan and similar substances, as well as in case of severe liver and kidney damage.
  Sorafenib also has potential to be toxic to the fetus, thus preventing contraception for both men and women during treatment and at least two months after stopping the drug. Women who are currently taking the drug are also advised not to breastfeed.
  The usual sorafenib dose is 400 mg, twice daily. Do not take the medication with meals, taking at least 1 hour before eating and 2 hours after eating.
• Sorafenib is also being tested for the treatment of advanced hepatocellular carcinoma, metastatic melanoma and non-small cell lung cancer …

Source: index-china.com

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Sorafenat drug price 200mg sorafenib

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