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Revolade medicine 50mg Eltrombopag treatment for thrombocytopenia
- Brand name: Revolade
- Active ingredient: Eltrombopag
- Manufacturer: Novartis / GSK
- Content: 50 mg
- Form: Tablets
- Package: Box of 14 tablets
- Prices for Revolade: COMMENT below for prices OR Click on the link: https://thuoclp.com/chatFB type “Revolade”
What medication is Revolade? Indications for treatment of Revolade 50mg
- Revolade (Eltrombopag) belongs to a class of drugs called thrombopoietin receptor agonists.
- Revolade is used to increase the number of platelets in the blood for adults with chronic immune thrombocytopenia (ITP).
- Revolade may be used to treat people who have removed their spleen and medications used as first-line treatments are no longer effective.
- Revolade can also be used to treat adults, who remove the spleen not an option but those with low platelet counts.
- Eltrombopag is also used to increase platelet counts for people infected with chronic hepatitis C virus, so they can use interferon to treat infections. This drug should only be used for people with chronic hepatitis C infection when the number of platelets in the blood is too low to start interferon treatment.
- Eltrombopag is also used to treat adults with severe aplastic anemia (SAA) when other treatments are not effective.
How does Revolade work?
In the body, a hormone called ‘thrombopoietin’ stimulates platelet production by attaching to certain targets in the bone marrow.
The active substance in Revolade, eltrombopag, attaches to and stimulates receptors similar to thrombopoietin. This leads to an increase in platelet production, improving platelet counts.
Dosage and use of Revolade 50mg
Dosage for chronic immune thrombocytopenia
Adults
- Initial dose: 50 mg once daily
- Maximum dose: 75 mg once daily
Children (from 1-5 years old)
- Initial dose: 25 mg once daily
- Maximum dose: 75 mg once daily
Change the dose: Your doctor will check your blood each week to check if this medicine is effective for you. Based on your platelet count, your doctor will increase or decrease your dose.
Dosage for low platelet counts from chronic hepatitis C
Adults
- Initial dose: 25 mg once daily
- Maximum dose: 100 mg once daily
Children
- It has not been confirmed that this drug is safe and effective when used in people under the age of 18 for this condition.
Change the dose: Your doctor will check your blood each week to check if this medicine is effective for you. Based on your platelet count, your doctor will increase or decrease your dose every two weeks. They will change your dosage by an increase of 25 mg.
Dosage for refractory severe aplastic anemia
Adults
- Initial dose: 50 mg once daily
- Maximum dose: 150 mg once daily
Children
- It has not been confirmed that this drug is safe and effective when used in people under the age of 18 for this condition.
Dose changes: Your doctor will check your blood once every two weeks to check if this medicine is working for you. Based on your platelet count, your doctor will increase or decrease your dose. They will change your dosage by an increase of 50 mg.
The first dose for severe aplastic anemia
- Adults: Initial dose of 150 mg once daily for 6 months.
- Children (aged 6 – 11 years): Initial dose: 75 mg once daily for 6 months
- Children (from 2 – 5 years old): The initial dose of 2.5 mg / kg once a day for 6 months.
Dose changes: Your doctor will check your blood regularly to check if this medicine is working for you. Based on your platelet count, your doctor will adjust your dose.
Consider special dosages
- For people with mild to severe liver disease: The typical starting dose is 25 mg once daily.
- For people of Asian origin: The typical starting dose is 25 mg once daily.
How to use the drug
Read the Medication Guide provided by your pharmacist before you start using eltrombopag and each time you are refilled. If you have any questions, consult your doctor or pharmacist.
Take this medication by mouth, usually once daily or as directed by your doctor. Take on an empty stomach, 1 hour before a meal or 2 hours after a meal.
Take this medicine at least 2 hours before or 4 hours after taking any product containing magnesium, aluminum or calcium. These products bind to eltrombopag, preventing its complete absorption.
Side effects Revolade 50mg
Eltrombopag may cause mild or serious side effects. The following list contains some important side effects that may occur while taking eltrombopag. This list does not include all possible side effects.
Serious side effects
- The risk of blood clots is higher due to sudden vascular markers
- Liver problems are marked with yellow in the skin or eyes, urine is unusually dark in color
- Decreased platelet count
- Bleeding in the digestive system is marked by black stools, vomiting blood, blood in your stool
Common side effects
- Diarrhea
- The lens is opaque in the eye
- Abnormal hair loss
- Skin rash
- Pain in the muscles or back or pain in the arms or legs
- Tingling or numb hands
- Heavy menstruation
- Mouth sores
- Difficulty sleeping
- Itching, runny or stuffy nose, sore throat
- Infections of the urinary system
- Meningitis
- Irregular heartbeat
- Increased blood sugar (glucose)
- Altering the enzymes that control blood clotting
- Increased levels of liver enzymes or bilirubin or certain proteins may appear in a blood test
Less common side effects
- Interruption of blood supply to a part of the heart
- Sudden shortness of breath
- Hematoma
- Sore throat and discomfort when swallowing, pneumonia, sinus, tonsils, nose and throat
- Influenza pneumonia
- Loss of appetite
- Joint pain due to uric acid (gout)
- Sleep problems, depression, lack of interest, mood swings
- Migraine
- Ear pain, feeling of rotation (dizziness)
- Rectal cancer
- Kidney problems
- Amount of blood reduced
- Changing the structure of the blood changes the concentration of uric acid, calcium and potassium
- Generally feeling unwell, high temperature, feeling hot, chest pain
- Pain when urinating
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptoms that worry you while you are taking this medication.
Warnings before using Revolade 50mg
These factors may affect how you should use this medicine:
Changes in blood cells: Eltrombopag stimulates cells in the bone marrow to produce platelets as well as other blood cells. Sometimes this causes changes in blood cells or bone marrow that can increase the risk of bone marrow cell disorders and blood cancer.
Blood clots: This drug may increase the risk of blood clots, causing reduced blood flow to organs or extremities.
Cataracts: Eltrombopag has been reported to cause cataracts or worsen them for people who have had the onset of cataracts before taking the medication.
Dizziness: Eltrombopag may cause dizziness, affecting the ability to drive a car or operate machinery. Avoid these and other dangerous tasks until you have determined how this medication affects you.
Hepatitis C infection: People with chronic hepatitis C infection may have an increased risk of liver failure and death while being treated with interferon and ribavirin.
Kidney function: Kidney disease or reduced kidney function may cause this medication to be ineffective.
Liver function: Liver disease or reduced liver function may cause this drug to build up in the body, causing side effects. Eltrombopag may impair liver function and may cause liver failure.
People of East Asian descent: When treating ITP and SAA, East Asian heritage populations may need to start with lower doses of eltrombopag. The dose for hepatitis C does not need to be adjusted.
Pregnancy: This drug should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Lactation: It is not known if eltrombopag passes into breast milk. If you are a nursing mother and are taking this medication, it could affect your baby. Talk to your doctor about whether you should continue breastfeeding.
Children: The safety and effectiveness of using this medicine have not been established for children.
Other drug interactions with Revolade 50mg
Increased side effects from other medications: Taking eltrombopag with certain medications increases the risk of side effects from these medications. Examples of these medications include:
- Bosentan, ezetimibe, glyburide, olmesartan, repaglinide, rifampin, valsartan, imatinib, irinotecan, thighs Your doctor may reduce the dose of these medications if necessary.
- Cholesterol-lowering medications like rosuvastatin, atorvastatin, fluvastatin, pitavastatin, Pravastatin, and simvastatin. Increased side effects may include myalgia. Your doctor may reduce the dose of cholesterol medication.
When used with eltrombopag, these drugs can make eltrombopag less effective. This means it will not work well to treat your condition. This is because the amount of eltrombopag in your body may be reduced. Examples of these medications include:
- Antacids, vitamins or supplements containing calcium, aluminum, iron, selenium, zinc or magnesium. To avoid interactions, you should use eltrombopag two hours before or four hours after taking any of these products.
Interact with food
- Foods containing calcium can make eltrombopag less effective. These foods include dairy products, such as milk and cheese.
- Take this medicine at least two hours before eating calcium-rich foods, or four hours after eating calcium-rich foods.
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