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Regonix medicine 40mg Regorafenib treatment of certain cancers
- Brand name: Regonix
- Active ingredient: Regorafenib
- Content: 40mg
- Form: Tablets
- Package: Box of 28 tablets
- Manufacturer: Beacon
- Regonix Drug Prices: COMMENT below for prices OR Click on the link: https://thuoclp.com/chatFB
What is regonix?
- Regonic is an anti-cancer drug that interferes with the growth and spread of cancer cells in the body.
- Regonix is a tumor suppressant that inhibits many kinases and oral signaling layers for the purpose of angiogen receptor, stromal and oncogen receptor kinrosine (RTK).
- Regonic shows anti-angiogenic activity due to its dual-targeted tyrosine kinase inhibition VEGFR2TIE2.
Indications for treatment of Regonix
Colorectal cancer: Regorafenib is indicated to treat patients with metastatic colorectal cancer (CRC) that has spread to other parts of the body that have previously been treated with Fluoropyrimidine, Oxaliplatin and chemotherapy based on Irinotecan, an anti-VEGF therapy, and if treated with anti-VEGF drugs.
Gastrointestinal tumors: Regorafenib is indicated for the treatment of patients with locally progressive, unresectable or metastatic gastrointestinal stromal tumor (GIST) previously treated with Imatinibmesylateand Sunitinib malate .
Hepatocellular carcinoma: Regorafenib is indicated for the treatment of patients with HCC who have been previously treated with Sorafenib.
Regorafenib is usually taken after other cancer medications have been used without success or for other purposes not listed in this medication guide.
How Regorafenib works
- Regorafenib is a small molecule inhibitor of many membrane and intracellular binding kinases involved in normal cell functions and in pathological processes such as oncogenesis, tumor generation, metastasis and immunity. tumor translation.
- In in vivo models, Regorafenib has demonstrated anti-angiogen activity in mouse tumor models and inhibited tumor growth in a number of mouse xenograft models including some for human colorectal cancer, cancer. gastrointestinal epithelial carcinoma and hepatocellular carcinoma.
- Regorafenib has also demonstrated anti-metastatic activity in mouse xenograft models and two mouse orthopedic models of human colorectal carcinoma.
- Regorafenib targets a number of different receptors, thereby preventing tumor growth and spreading over a period of tumors and angiogenesis formation of a tumor blood supply.
Dosage and Usage of drugs regonix
The dosage is based on your medical condition and response to treatment.
- Recommended dose: 160 mg of four 40 mg tablets orally once a day for the first 21 days of each 28 day cycle.
- Continue treatment until the disease progresses or the toxicity no longer exists.
How to use the drug Regonix
- Use Regonix at the same time each day. Use after a low-fat meal containing less than 600 calories less than 30% fat.
- Swallow the tablet whole with water. Do not crush, chew or break a tablet.
- Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time every day.
- Remove any unused tablets 7 weeks after opening the bottle.
Do not arbitrarily increase your dose or use this medication for longer than directed by your doctor. Your condition will not improve faster and the risk of serious side effects will increase.
What happens if a dose is missed?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Call the doctor immediately or go to the nearest medical facility for timely assistance, avoiding possible side effects.
Important information to know before using Regonix
Do not use Regonix if you have ever had the following health problems:
- Liver or kidney disease
- Bleeding problem
- High Blood Pressure
- Heart problems or chest pain
Do not use this medicine if you are about to have surgery or recently had surgery.
Pregnant women: Do not use Regonix for pregnant women. It can cause birth defects in the fetus, using highly effective contraception when treated with Regonix. Notify your doctor immediately if you are pregnant while using this medicine.
Women who are breastfeeding should not use this medication, Regonix may pass into breast milk harming the baby. Consult your doctor about treatment with Regonix if you are breast-feeding a baby.
Side effects of Regonix
Regonix may cause some unwanted effects. Although not all of these side effects can occur, if they occur, they may need medical attention.
Serious side effects : severe and fatal liver toxicity occurs in patients treated with Regonix
Serious side effects, occurring in less than 1% of patients:
- Liver damage,
- severe bleeding,
- blistering and peeling of the skin,
- High blood pressure requires emergency treatment,
- heart attack
- perforation of the intestine.
The most common side effects reported in patients treated with regorafenib include:
- weak or tired,
- anorexia,
- limb syndrome (also called erythrodysesthesia),
- diarrhea, mouth sores (mucositis),
- weight loss,
- infection,
- High Blood Pressure,
- Change in volume or voice quality.
Drug interactions
Drug interactions can change the way a drug works or increase your risk of serious side effects.
Many drugs may interact with Regonix. This includes drugs obtained with or without a prescription, vitamins and herbal products:
- The altered interaction in the strong CYP3A4 inducers (e.g. rifampin) and inhibitors (e.g. clarithromycin, grapefruit juice, itraconazole, ketoconazole, posaconazole, telithromycin and voriconazole).
- May increase system exposure to UGT1A1 & UGT1A9 substances; Plasma concentrations of breast cancer-fighting protein (eg, methotrexate) or Pglycoprotein (eg, digoxin) substrate. May affect exposure to midazolam.
- Herbal supplements that contain St. John’s wort.
Grapefruit juice and grapefruit juice may interact with Regonix and lead to potentially dangerous effects. Avoid using grapefruit products while taking Regonix.
Not all possible interactions appear in this medication guide. Tell your doctor about all medicines you use, and any you start or stop using.
Self-care tips
- Drink at least two to three liters of water daily, unless you have been told otherwise.
- Wash your hands often.
- You may be at risk of infection so try to avoid crowds or people with a cold, and report fever or any other signs of infection immediately to your healthcare provider. friend.
- Ask a doctor or nurse before scheduling dental appointments or procedures.
- If you should be nauseous, take anti-nausea medication as prescribed by your doctor and eat small meals regularly. Sucking on lozenges and chewing gum may also help.
- Avoid sun exposure. Wear long clothes or apply sunscreen.
- Alcoholic beverages should be avoided completely. You should discuss this with your doctor.
- Get plenty of rest and maintain good nutrition.
- If you experience symptoms or side effects, be sure to discuss them with your health care team. They may prescribe medications or make other suggestions that are effective in managing those issues.
Preserving the drug
Store this medicine at room temperature 25 ° C, away from direct light and moisture,
Keep out of reach of children and pets
Do not throw medication into the sink or in the toilet or household waste. Ask your pharmacist how to get rid of medications that are no longer needed or have expired.
Source: index-china.com
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