Drug information Orib 200mg Sorafenib treats liver and kidney cancer
|Pack||box of 120 tablets|
What is Orib 200mg?
Orib drug active ingredient is the anticancer drug sorafenib, protein kinase inhibitors are used to treat some cancers, such as liver cancer, kidney cancer.
The drug is prepared in the form of tablets, the content of Sorafenib 200mg.
Sorafenib’s mechanism of action
The active ingredient sorafenib is a multikinase inhibitor that reduces tumor cell proliferation in vitro. Sorafenib inhibited tumor growth of a variety of human tumor xenografts in healthy mice accompanied by a reduction in tumor angiogenesis.
Sorafenib inhibits the activity of targets present in tumor cells (CRAF, BRAF, V600E BRAF, c-KIT and FLT-3) and in tumor vasculature (CRAF, VEGFR-2, VEGFR-3 and PDGFR) -ß).
RAF kinases are serine/threonine kinases, while c-KIT, FLT-3, VEGFR-2, VEGFR-3 and PDGFR-ß are receptor tyrosine kinases.
Dosage and how to use Orib?
Dosage of Orib
- Hepatocellular carcinoma (HCC): Oral: 400mg twice daily.
- Renal cell cancer (RCC), advanced: Oral: 400mg twice daily.
- Thyroid cancer, differentiated: Oral: 400mg twice daily.
How to use Orib?
Use medications exactly as directed by your doctor, medications taken by mouth. Take Orib on an empty stomach, at least 1 hour before or 2 hours after eating.
Your blood pressure will need to be checked often.
If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using Orib. You may need to stop using the medicine for a short time.
What to do in case of overdose?
The highest dose of sorafenib clinically studied was 800 mg twice daily. The adverse events observed at this dose were mainly diarrhea and dermatological events.
- Call 911 immediately or go to the nearest local health station.
- Of course, you’ll need to keep a record and bring a list of all the medications you’ve taken, including prescription and over-the-counter drugs.
What should I do if I miss a dose of Orib ?
- If you forget to take a dose, take it as soon as possible.
- But if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time.
- Do not take double the prescribed dose.
Orib 200mg side effects
Common adverse reactions: diarrhea, fatigue, hair loss, infection, hand and foot skin reactions and rash.
Common side effects of taking Orib:
- Lymphocyte reduction;
- Hemorrhage (including: gastrointestinal tract, respiratory tract and cerebral hemorrhage);
- Diarrhea, nausea, vomiting, constipation;
- Dry skin, rash, hair loss, erythema pruritus;
- Fatigue, pain, fever;
- decreased weight, increased amylase, increased lipase.
Uncommon side effects:
- Hypersensitivity reactions, anaphylactic reactions;
- Interstitial lung disease-like events ( pneumonia , radiation pneumonia, acute respiratory failure, etc.);
- Gastritis, pancreatitis, gastrointestinal perforation;
- Jaundice, cholecystitis, cholangitis;
- Indigo, you pour.
Any warning when taking the drug?
You should not use Orib if you have squamous cell lung cancer, or if you have squamous cell lung cancer and you are being treated with carboplatin and paclitaxel.
Orib medicine can cause heart problems. Get emergency medical help if you have: chest pain, fast heartbeat, trouble breathing, or swelling around your midsection or lower legs.
Tell your doctor if you have ever had:
- Heart disease, high blood pressure;
- Long QT syndrome (in you or a family member);
- Bleeding problems;
- Electrolyte imbalance (such as abnormal levels of calcium, magnesium, or potassium in the blood).
For pregnant & lactating women
The drug causes birth defects in the unborn baby. Sorafenib should not be used during pregnancy unless clearly needed, after careful consideration of the mother’s needs and the risk to the fetus.
Breast-feeding: do not breast-feed while using this medicine, and for at least 2 weeks after your last dose.
If you are a man, use effective birth control if your partner is pregnant or could become pregnant. Continue using birth control for at least 3 months after your last dose.
People who are working, driving or operating machinery
No studies on the effects on the ability to drive and use machines have been performed. There is no evidence that Orib affects the ability to drive or use machines.
What other drugs may interact with Orib?
Sometimes it is not safe to use several medicines at the same time. Some medicines can affect your blood levels of other medicines you take. This can increase side effects or make the medicine less effective.
Other drugs may affect Orib . Includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any you start or stop using.
How much does Orib 200mg cost? Buy Orib
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How to store medicine?
- You should store the medicine at room temperature, in a cool, dry place, away from direct sunlight.
- You should not store the medicine in the refrigerator.
- Keep the medicine out of the reach of children.
- Do not throw medicine down the toilet or plumbing.
The above article is for reference only and is not a substitute for medical diagnosis or treatment. Readers should only follow the instructions of the doctor who is treating you, Index-China disclaims responsibility if problems occur.
Reference source ThuocLP Vietnamese: Orib medicine (Sorafenib) is used to treat liver and kidney cancer
Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.