What is Ledviclear?
Ledviclear drug is an antiviral medicine that stops hepatitis C virus (HCV) cells from multiplying in your body, a combination medicine used to treat hepatitis C in adults. The drug may also be used for purposes not listed in the medication guide.
Drug information Ledviclear active ingredients Ledipasvir and Sofosbuvir content 90mg/400mg
- Brand Name: Ledviclear.
- Active ingredients: Ledipasvir and Sofosbuvir.
- Manufacturer: Abbott – Origin: India.
- Strength: 90mg and 400mg.
- Form: Tablets.
- Packaging: Box of 28 tablets.
What is Ledviclear’s Important Safety Information?
- You should not use Ledviclear if you are allergic to Ledipasvir or Sofosbuvir.
- To be on the safe side, tell your doctor if you have a history of hepatitis B, liver problems other than hepatitis, a history of liver transplant, kidney disease (or if you are on dialysis), HIV or AIDS.
How does Ledviclear work?
This medication works by blocking the replication of nonstructural protein 5A (NS5A) which is a viral phosphoprotein. Thus, Ledipasvir binds itself to NS5A to suppress the secretion, replication and production of viral RNA infection.
What does Ledviclear do?
The drug is indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) infection:
- Genotype 1, 4, 5 or 6 infection without cirrhosis or with compensated cirrhosis.
- Genotype 1 infection with decompensated cirrhosis, used in combination with ribavirin.
- Genotype 1 or 4 infection is a liver transplant recipient without cirrhosis or with compensated cirrhosis, used in combination with ribavirin
Ledviclear tablets are indicated for the treatment of children 12 years of age and older or weighing at least 35 kg with HCV genotype 1, 4, 5 or 6 infection without cirrhosis or with compensated cirrhosis.
Dosage and how to use Ledviclear?
- Ledviclear (Ledipasvir-sofosbuvir (90 mg/400 mg)) is a fixed-dose combination tablet.
- The recommended dose is 1 tablet once a day.
How to take medicine
- Take this medication with or without food as directed by your doctor, usually once daily.
- This medicine works best when the amount of medicine in your body is kept constant. So take this medicine at evenly spaced intervals. To help you remember, take your medicine at the same time each day.
- Tell your doctor if you vomit within 5 hours of taking this medicine. You may need to take another dose.
- Continue taking Ledviclear for the full length of time prescribed, even if symptoms disappear after a short time. Stopping the medication too soon can cause the infection to return.
- Antacids reduce the absorption of Ledipasvir. If you are taking an antacid, take it at least 4 hours before or 4 hours after taking this medicine.
- Other acid-reducing medicines for indigestion, heartburn, or ulcers (such as prescription or over-the-counter medicines including famotidine, omeprazole) may prevent Ledipasvir from working. Ask your doctor or pharmacist how to use these medicines safely.
Ledviclear drug side effects
When you take this medicine for hepatitis, it is important to be aware of changes in your body and how you are feeling. This medicine may cause some side effects. Side effects can range from mild to severe, and the risk of side effects varies from person to person. The following is a list of possible side effects:
Common side effects: fatigue, headache, diarrhea, loss of appetite, feeling sad, rash, trouble sleeping, trouble concentrating, irritability, depression.
Serious side effects: chest pain or discomfort, shortness of breath, slow or irregular heartbeat, dizziness or fainting, unusual tiredness.
This is not a complete list of side effects and other possible side effects. Tell your healthcare provider about any side effects that bother you or don’t go away.
What other drugs may interact with Ledviclear?
All drugs interact differently from person to person. You should check all possible interactions with your doctor before starting any medication.
Some drugs that may interact with Ledviclear include: carbamazepine, rifampicin, fosphenytoin, digoxin, amiodarone, linagliptin.
Interaction with alcohol: interaction with alcohol is unknown. You should consult your doctor before consuming.
Effects on pregnant or lactating women
- Ledviclear is not recommended for use in pregnant women unless clearly needed.
- All risks and benefits should be discussed with your doctor before taking this medication.
- The drug is not recommended for use by women who are breastfeeding unless absolutely necessary.
- All risks and benefits should be discussed with your doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or discontinue the drug based on your clinical condition.
- If you are allergic to sofosbuvir or ledipasvir or any other drugs or ingredients, tell your doctor.
- If you are taking any prescription, over-the-counter medications, vitamins, supplements, or any type of herbal product, tell your doctor.
- If you are consuming magnesium hydroxide or antacids containing aluminum hydroxide, take them at least 4 hours before or after taking ledipasvir and sofosbuvir.
- Use caution with the drug if you are pregnant, nursing or planning to become pregnant.
Special notes on Ledviclear medicine
- Bradycardia when co-administered with amiodarone: Severe symptomatic bradycardia may occur in patients receiving amiodarone and Sofosbuvir in combination with another direct-acting antiviral (DAA), particularly in patients who are also taking beta-blockers, or those with congenital heart disease or advanced liver disease.
- Co-administration of amiodarone with Sofosbuvir in combination with another DAA is not recommended. In patients without viable, alternative treatment options, cardiac monitoring is recommended.
- Pregnancy: Ribavirin can cause birth defects and fetal death, and animal studies have shown that interferon is effective in aborting and preventing pregnancy in female patients and male partners. . Patients must have a negative pregnancy test before starting treatment.
How to store Ledviclear?
- Store below 30°C (86°F).
- Store in a cool, dry place, protected from light and refrigerate when needed. Improper storage can affect the effectiveness and shelf life of the medicine.
- Consider storing medications separately from other family members. You can put them on another shelf, or in another cabinet or drawer.
- Always store Ledviclear out of reach and sight of children.
How much does Ledviclear cost? Buy Ledviclear medicine
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Note: Information about the article about Ledviclear 90mg/400mg Ledipasvir and Sofosbuvir for the purpose of sharing knowledge for reference only, patients are not allowed to use the drug on their own, all information on drug use must be according to the doctor’s prescription specialist.
Reputable source ThuocLP Vietnamese: Ledviclear medicine 90mg/400mg Ledipasvir and Sofosbuvir treat hepatitis C
Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.