What is Ledifos?
Ledifos medicine is a combination of two antiviral drugs. This prescription medication is used to treat chronic hepatitis C virus (HCV) infection. It fights against the virus to resolve the infection.
Drug information Ledifos 90mg Ledipasvir / 400mg Sofosbuvir to treat hepatitis C
- Brand Name: Ledifos
- Active ingredients: Ledipasvir and Sofosbuvir
- Manufacturer: HETERO Labs Limited India Pharmaceutical Company
- Content: 90mg and 400mg
- Form: Tablets
- Packing: Box of 28 tablets
How does Ledifos work?
In Ledifos, Ledipasvir belongs to a class of drugs known as fluorenes. It works by inhibiting a protein, which is necessary for viral replication. Therefore, it prevents the growth of viruses. Sofosbuvir is a nucleotide polymerase inhibitor, which works by inhibiting the polymerase enzyme. This helps prevent the virus from multiplying.
What should I pay attention to before taking Ledifos?
- If you are allergic to Ledipasvir and Sofosbuvir or any of the other ingredients in Ledipasvir. Tell your doctor about any allergies and symptoms you have.
- If you have ever had liver problems other than hepatitis C.
- If you are taking another medicine that has the same medicine in it.
- If you take any medicines (prescription or OTC, natural products, vitamins) that should not be taken with Ledipasvir, like some medicines used for HIV, infections or epilepsy. There are many medicines that should not be taken with Ledipasvir.
This is not a list of all drugs or health problems that interact with Ledipasvir. Tell your doctor and pharmacist about all of your medicines (prescription or OTC, natural products, vitamins) and your health problems.
You must check to make sure that it is safe for you to take Ledipasvir with all of your drugs and health problems. Do not start, stop, or change the dose of any medicine without checking with your doctor.
What are some things I need to know or do while taking Ledifos?
For all patients taking Ledifos:
- Tell all of your healthcare providers that you take Ledifos. This includes your doctor, nurse, pharmacist and dentist.
- The drug can be used with ribavirin. If you are also taking ribavirin, talk to your doctor about the risks and possible side effects.
- Have your blood work checked when you have been ordered by your doctor. Talk to your doctor.
- It is not known whether Ledifos prevents the spread of diseases such as hepatitis through blood or sexual contact. Do not have sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors. Talk to your doctor.
- Bradycardia and the need for a pacemaker have occurred when amiodarone is used together with sofosbuvir and certain other hepatitis C medicines. At times, this has been deadly. A bradycardia that has occurred up to 2 weeks after starting hepatitis C treatment. You will need to be watched closely if you will be taking amiodarone along with hepatitis C treatment. Do what your doctor has told you to do. do. Call your doctor at once if you have signs of a slow heart rate such as chest pain, confusion, dizziness, fainting or near fainting, memory problems, trouble breathing, fatigue, or weakness.
- Tell your doctor if you are pregnant, plan to become pregnant or are breast-feeding. You will need to talk about the benefits and risks to you and your baby.
- If giving your child medication and your child’s weight changes, talk to your doctor. It may be necessary to change the dose of Ledifos.
What is the best way to take Ledifos?
- Use Ledifos as directed by your doctor. Read all the information provided to you. Follow all instructions closely.
- Bring food or not.
- Do not take antacids within 4 hours of taking them.
- If you take cimetidine, dexlansoprazole, esomeprazole, famotidine, lansoprazole, nizatidine, omeprazole, pantoprazole, rabeprazole, or ranitidine, ask your doctor or pharmacist how to take Ledifos.
- Continue taking your medicine as you have been told by your doctor or other healthcare provider, even if you feel well.
- It is important that you do not miss or skip a dose of Ledifos during treatment.
- If you have trouble swallowing, talk to your doctor.
- Patients should stay away from H2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) because they reduce Ledipasvir levels.
- In addition, Ledipasvir / Sofosbuvir should be avoided when taking amiodarone or other drugs that decrease heart rate, there is a risk of serious bradycardia or stopping when Ledipasvir / Sofosbuvir is used with such medicines.
Do not take Ledifos if you are allergic to ledipasvir or sofosbuvir.
Do not take it if you are taking another medicine that contains sofosbuvir.
Using the drug under certain circumstances may pose some risk to you or be preventable if it doesn’t work as intended. Before starting treatment, you should tell your doctor if:
- You are pregnant, planning to become pregnant or breast-feeding
- You are currently taking any prescription or over-the-counter medications (including herbal treatments and supplements)
- You have had an allergic reaction to a drug, food, or other substance in the past
- You have kidney or liver problems
Some drugs may prevent Ledifos from working properly or may have specific actions that are inhibited by Ledifos.
- Simeprevir may increase the risk of side effects from ledipasvir and sofosbuvir.
- Carbamazepine, oxcarbazepine, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, St. John’s wort, or tipranavir may decrease the effectiveness of ledipasvir and sofosbuvir.
- The risk side effects of Digoxin or Rosuvastatin may be increased with the use of ledipasvir and sofosbuvir.
How much does Ledifos cost? Buy Ledifos
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Preservation of drugs
- Store in original container at room temperature.
- Keep in dry places. Do not store in the bathroom.
- Keep all medications in a safe place. Keep all medications out of the reach of children and pets.
- Throw away unused or expired medication. Do not flush down the toilet or down the drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to get rid of the medicine. There may be drug recall programs in your area.
Note: Information about the article about Ledifos 90mg/400mg Ledipasvir and Sofosbuvir for the purpose of sharing knowledge for reference only, patients are not allowed to use the drug on their own, all information on drug use must be according to the doctor’s prescription specialist.
Reputable source ThuocLP Vietnamese: Ledifos medicine 90mg/400mg Ledipasvir and Sofosbuvir treat hepatitis C
Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.