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Jakavi medicine 20mg Ruxolitinib bone marrow disorders
- Brand name: Jakavi 20mg
- Active ingredient: Ruxolitinib
- Manufacturer: Novartis
- Content: 20 mg
- Package: Pack of 56 tablets
- Jakavi Prices: COMMENT below for prices OR Click on the link: https://thuoclp.com/chatFB type “Jakavi”

The use of the drug Jakavi 20mg
You can use ruxolitinib medicine to treat a number of bone marrow disorders: bone marrow fibrosis, primary polycythemia.
The drug works by stopping the body from producing growth factors. Growth factors cause cells to grow and divide, causing blood and spleen problems in these disorders.
Ruxolitinib belongs to the group of JAK inhibitors. Although ruxolitinib does not cure these disorders, this medication may be helpful for a number of symptoms, including abdominal discomfort, pain under the left rib, feelings of fullness, night sweats, itching and bone / muscle pain.
What is Jakavi used for?
Jakavi is used to treat the following conditions:
Myelofibrosis (MF)
- Jakavi is indicated for the treatment of enlarged spleen or disease-related symptoms in adult patients with primary myeloma also known as chronic idiopathic muscle atrophy, thrombocytosis after polycythemia vera.
Polycythemia vera (PV)
- Polycythaemia vera in adults is resistant or intolerant to treatment with hydroxyurea drugs.
- Polycythaemia vera is a disease that mainly causes too many red blood cells to be produced, which can reduce blood flow to organs due to the ‘thick’ of blood and sometimes the formation of blood clots.
The drug is only sold and used as directed.
How to use Jakavi 20mg
The recommended starting dose of jakavi 20mg depends on the condition to be treated and the baseline level of some blood cells (eg, platelets, hemoglobin, neutrophils). Your doctor will adjust your dose based on how you respond to and tolerate this medication.
- In myelofibrosis: the recommended starting dose is up to 20 mg twice daily depending on the number of platelets.
- In polycythaemia vera: the recommended starting dose is 10 mg twice a day.
If treatment is not considered to be sufficiently effective, the dose may be increased by 5 mg to 25 mg twice a day.
A low dose should be used in certain cases, including in patients with impaired liver function or severe impairment of renal function, and in patients taking certain other medications.
Treatment should be stopped if the blood concentration of platelets or neutrophils of a type of white blood cell falls below a certain threshold, or if there is no improvement in the size or symptoms of the spleen. watch after six months.
In the treatment of polycythaemia vera should also be stopped when the hemoglobin concentration is very low.
The benefits of Jakavi have been studied
In myelofibrosis: Jakavi is more effective than placebo and the best treatment available in reducing the size of the spleen.
- In the first study, a goal of reduction in splenic size was achieved in 42% of patients treated with Jakavi (65 out of 155) compared to less than 1% of patients receiving placebo (1 in 153).
- In the second study, a reduction in splenic size was achieved in 29% of Jakavi patients (41 out of 144) compared to 0% of the best treated patients (0 out of 72).
In polycythemia vera : 21% (23 out of 110) of patients on Jakavi showed improvement after 8 months of treatment, compared to 1% (1 in 112) of the best treated patients.
Jakavi 20mg side effects
When you take Jakavi cancer medicine, it is important to be aware of changes in your body and feelings. This medicine can cause a number of side effects that can range from mild to severe and the risk of side effects varies from person to person. The following is a list of possible side effects:
Common side effects:
- Headache;
- Dizzy;
- Tired;
- Weak;
- Shortness of breath;
- Weight gain;
- Constipation;
- High cholesterol;
- Diarrhea;
- Nose bleeds, etc.
Serious side effects:
- unusual bleeding or bruising;
- Low blood cell count;
- Infection;
- Anemia;
- Cloudy urine;
- Tiny, red or purple spots on the skin, etc.
This is not a complete list of side effects. Please inform your doctor if you experience any adverse reactions to the medication
Caution before using Jakavi 20mg
You should not use jakavi if you are allergic to ruxolitinib or any of its ingredients.
Tell your doctor if you, anyone in your family has tuberculosis, or if you recently traveled to a common area of TB.
To make sure Jakavi is safe for you, tell your doctor if you have:
- any type of active infection;
- kidney disease or if you are on dialysis;
- liver disease, especially hepatitis B;
- history of skin cancer;
- High cholesterol or triglyceride: a type of fat in the blood.
Using Jakavi may increase your risk of developing skin cancer. Talk to your doctor about this risk and skin symptoms to watch out for.
It is not known whether Jakavi will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
Jakavi can pass into breast milk and it can harm a nursing baby. You should not breast-feed while you are using Jakavi.
Other drug interactions with Jakavi 20mg
Tell your doctor about all other medicines you are taking, including prescription drugs or any medications you buy without a prescription from a pharmacy, supermarket or health food store.
Some medications and Jakavi can interfere with each other. Including:
- certain medications used to treat fungal infections. These include drugs like ketoconazole, itraconazole, posaconazole and voriconazole
- certain medicines used to treat bacterial infections. These include antibiotics such as ciprofloxacin, clarithromycin, erythromycin or telithromycin.
- certain medications used to treat viral infections
- Some medications used to treat fungal infections like ketoconazole, itraconazole, posaconazole, fluconazole and voriconazole
- drugs used to treat HIV / AIDS such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir
- certain medications used to treat high blood pressure such as verapamil, nifedipine or carvedilol.
Talk to your doctor about drug interactions of any medicine you are taking or mentioned above.

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Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Medical Certificate:
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.
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