Jakavi 15mg Ruxolitinib bone marrow disorders

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Jakavi 15mg Ruxolitinib bone marrow disorders

• Brand name: Jakavi 15mg
• Active ingredient: Ruxolitinib
• Manufacturer: Novartis
• Content: 15 mg
• Form: Tablets
• Package: 1 box of 56 tablets
• Jakavi Prices: COMMENT below for prices OR Click on the link: https://thuoclp.com/chatFB type “Jakavi”

What is ruxolitinib used for?

You can use ruxolitinib to treat a number of bone marrow disorders (osteomyelitis, polycythemia vera).

The drug works by stopping the body from producing growth factors. Growth factors cause cells to grow and divide, causing blood and spleen problems in these disorders.

Ruxolitinib belongs to the group of JAK inhibitors. Although ruxolitinib does not cure these disorders, this medication may be helpful for a number of symptoms, including abdominal discomfort, pain under the left rib, feelings of fullness, night sweats, itching and bone / muscle pain.

Indications for treatment of Jakavi 15mg drug

Myelofibrosis (MF)

• Jakavi is indicated for the treatment of symptoms of splenomegaly or diseases involving adult patients with primary myelofibrosis also known as chronic idiopathic myelofibrosis, post-polycythaemia vera myelofibrosis or myelofibrosis thrombocythaemia.

Polycythaemia vera (PV)

• Jakavi is indicated for the treatment of adult patients with hydrocyurea resistant or intolerant polycythaemia vera.

Dosage of drugs Jakavi

The information provided is not a substitute for medical advice. Always consult your doctor or pharmacist before deciding to take your medication.

What is the dose of ruxolitinib for adults?

Usual adult dose for myelodysplastic disorders:

Initial dose:

• If the platelet count is more than 200 x (9) 10 / l, you take 20 mg orally twice a day;
• If the platelet count is 100-200 x 10 (9) / l, you take 15 mg orally twice a day;
• If your platelet count is 50 to less than 100 x (9) 10 / l, take 5 mg orally twice a day.

Maximum dose:

• If the initial platelet count is 100 x 10 (9) / l or more, take 25 mg orally twice a day;
• If the initial platelet count is 50 to less than 100 x 10 (9) / l, you should take 10 mg orally twice a day.

The duration of treatment will last 6 months if the condition of the spleen does not improve and symptoms do not improve.

What is the dose of ruxolitinib for children?

• Dosage for children has not been studied and decided. Consult your doctor if you plan to give this medication to a child.

How is Jakavi used?

• Jakavi treatment should only be initiated by a physician experienced in treating patients with cancer medicine. Complete blood cell count of the patient must be taken before starting treatment and monitored during treatment.
• In myelofibrosis, the recommended starting dose is up to 20 mg twice daily depending on the number of platelets. In polycythaemia vera, the recommended starting dose is 10 mg twice a day.
• If treatment is not considered to be sufficiently effective, the dose may be increased by 5 mg to 25 mg twice a day.
• A low dose should be used in certain cases, including in patients with impaired liver function or severe impairment of renal function, and in patients taking certain other medications. Treatment should be stopped if the blood concentration of platelets or neutrophils (a type of white blood cell) falls below a certain threshold, or if there is no improvement in scale or leaf symptoms. Spleen is viewed after six months. In the treatment of polycythaemia vera should also be stopped when the hemoglobin concentration is very low.

How does Ruxolitinib work?

• The active ingredient in Jakavi, ruxolitinib, works by blocking a group of enzymes called Janus kinase (JAKs), which are involved in the production and growth of blood cells. In myelofibrosis and polycythaemia vera, there is excessive JAK activity, which leads to abnormal production of blood cells. 
• Blood cells move to organs including the spleen, causing them to expand. By blocking JAKs, Jakavi reduces the abnormal production of blood cells, thereby reducing the symptoms of the disease.

How has Jakavi been studied?

In myelofibrosis, Jakavi was investigated in two main studies involving 528 patients. The first study compared Jakavi with placebo (a dummy treatment). The second study compared Jakavi with the best treatment available, which included different types of drugs like anticancer drugs, hormones and immunosuppressants. The main measure of effectiveness is that the proportion of patients with spleen has decreased in size by at least 35%, measured after six months in the first study and after a year in the second study.

In polycythaemia vera, Jakavi was studied in a major study that involved 222 patients who were resistant or intolerant to hydroxyurea therapy. This study, which compared Jakavi with the best available treatment, looked at the proportion of patients who showed improvement in their condition, measured as required with or without more than one injection. procedure to remove excess blood from the body) and the spleen is reduced by at least 35% in size, after 8 months of treatment.

Jakavi 15mg side effects

Call emergency date if you have any of the following signs of an allergic reaction: rash; shortness of breath; swelling of face, lips, tongue or throat.

Some of the side effects may be similar to the symptoms of bone marrow sclerosis. See a doctor right away if you have a serious side effect such as:

• Cyanosis, feeling delirious or short of breath, tachycardia, loss of concentration;
• Easy bruising, unusual bleeding (nose, mouth, vagina or rectum), purple or red spots under the skin;
• Fever, chills, body aches, flu symptoms, vomiting, mouth and throat sores;
• Pain or burning during urination;
• Scaly skin or painful skin rash.

Less serious side effects may include:

• Headache;
• Dizzy;
• Weight gain;
• Flatulence

Not everyone experiences the above side effects. There may be other side effects not mentioned. If you have any questions about side effects, consult your doctor or pharmacist.

What are the risks associated with Jakavi?

In myelofibrosis, the most common side effects with Jakavi are:

• thrombocytopenia: low blood platelet count,
• anemia: low red blood cell count,
• Leukopenia: low level of neutrophils,
• urinary tract infection: infection of the structures that carry urine,
• bleed,
• bruising,
• weight gain,
• Hypercholesterolemia: high blood cholesterol,
• dizziness, headache and raised liver enzyme levels.

In polycythaemia vera, the most common side effects with Jakavi are:

• thrombocytopenia: low blood platelet count,
• anemia,
• bleed,
• bruising,
• Hypercholesterolemia: high blood cholesterol,
• hypertriglyceridemia: high blood fat levels,
• dizziness, increased liver enzyme levels and high blood pressure.

Jakavi is not to be used in women who are pregnant or nursing. For a complete list of all side effects and limitations with Jakavi, please see the package leaflet.

Caution before using medicine Jakavi 15mg

Tell your doctor and pharmacist if you are allergic to ruxolitinib, any other medicines or any ingredients in ruxolitinib tablets. Ask your pharmacist for a list of tablet ingredients.

Tell your doctor and pharmacist about other prescription and over-the-counter medicines, vitamins and nutritional supplements, herbal products that you are taking or plan to take. Be sure to mention the following medications:

Antifungal drugs include:

• itraconazole (Sporanox),
• ketoconazole (Nizoral),
• posaconazole (Noxafil);
• voriconazole (Vfend);
• boceprevir (Victrelis);
• clarithromycin (Biaxin, in Prevpac);
• conivaptan (Vaprisol);

HIV protease inhibitors include:

• indinavir (Crixivan),
• lopinavir ritonavir (Kaletra) combination drug,
• nelfinavir (Viracept),
• ritonavir (Norvir)
• saquinavir (Invirase);
• mibefradil (Posicor);
• nefazodone (Serzone);
• rifampin (Rifadin, Rifamate, Rimactane, others);
• telaprevir (Incivik);
• telithromycin (Ketek).

Your doctor may need to change the dose or monitor carefully for side effects. Many other drugs can also interact with ruxolitinib, so be sure to tell your doctor about all medicines you are taking, even those that are not listed on this list.

Tell your doctor if you have anemia, infection or dialysis or if you have or have ever had kidney or liver disease.

Tell your doctor if you are pregnant, planning to become pregnant or breastfeeding. If you become pregnant while taking ruxolitinib, call your doctor. You should not breast-feed while taking ruxolitinib.

If you need surgery, including dental surgery, tell your doctor or dentist about your use of ruxolitinib.

Source: index-china.com

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