What is Elbonix?
Elbonix medicine contains the active ingredient Eltrombopag, which is used to treat chronic immune thrombocytopenia (ITP) in adult patients resistant to other treatments; of Beacon Pharmaceuticals Company – Bangladesh.
The drug should only be used under the guidance of a specialist.
Elbonix drug information
- Ingredients: Eltrombopag.
- Dosage form: Tablets.
- Packaging: Box of 28 tablets.
- Producer: Beacon Banglades.
Types of content
- Elbonix medicine 25mg: Each box contains 28 tablets, Eltrombopag content 25mg
- Elbonix 50mg: Each box contains 28 tablets, Eltrombopag content 50mg.
How does Elbonix work?
Active ingredient eltrombopag is an orally biologic, small molecule TPO receptor agonist that interacts with the cell membrane region of the human TPO receptor and initiates signaling cascades that induce proliferation and differentiation from bone marrow progenitor cells.
Indications for drug use
Patients with ITP: have a low blood platelet count (thrombocytopenia) leading to an increased risk of hemophilia; used for adults or children 1 year of age or older, have had the disease for at least 6 months.
Thrombocytopenia in adults with chronic hepatitis C: Chronic hepatitis C is caused by hepatitis C virus (HCV).
Severe aplastic anemia: The bone marrow does not make enough blood cells or platelets.
Contraindications to the use of Elbonix
You should not use if you are allergic to eltrombopag if.
Call your doctor at once if you have signs of liver problems: nausea, upper stomach pain, confusion, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin) skin or eyes).
What is the dose of Elbonix?
Patients on chronic immune thrombocytopenia (ITP):
Initial dose: Use 50mg once daily for most adult patients and children 6 years of age and older and use 25mg once daily for pediatric patients 1-5 years of age.
For patients with hepatic impairment and some patients of East Asian ancestry: Dosage reduction or adjustment is required to maintain a platelet count greater than or equal to 50 x 109/L. The adjusted dose should not exceed 75mg per day.
Patients treated for chronic thrombocytopenia associated with hepatitis C:
Initial dose: 25 mg daily for all patients.
Dose adjustment: Adjust to achieve the target platelet count needed to initiate antiretroviral therapy. The adjusted dose should not exceed 100mg a day.
Patients treated for severe aplastic anemia:
Initial dose: Use 50mg daily for most patients.
For patients with hepatic impairment or patients of East Asian ancestry: Initial dose reduction is required, dose titration to maintain platelet count greater than 50 x 10/L. Do not exceed 150 mg per day.
How to use Elbonix medicine effectively?
- The drug is taken orally, taken on an empty stomach, at least 1 hour before or 2 hours after a meal.
- Do not take with calcium-fortified dairy products or juices.
- The side should swallow the tablet whole and do not crush, chew, or break it.
Be careful while using the drug
Avoid all dairy products or products containing calcium (including fortified fruit juices) for at least 4 hours before or 2 hours after you take the medicine.
Avoid activities that may increase your risk of bleeding or injury. Use with care to prevent bleeding while shaving or brushing teeth.
Tell your doctor if you have:
- A blood clot.
- Liver disease (unless you are being treated for hepatitis c).
- Kidney disease.
- Myelodysplastic syndrome (also known as preleukemia).
- Have had surgery to remove the spleen.
- If you are of East Asian descent (Chinese, Japanese, Taiwanese or Korean).
- If you have myelodysplastic syndrome, taking elbonix may increase your risk of leukemia (a type of blood cancer that can be fatal).
What to do in case of overdose?
Call 911 immediately or go to the nearest local health station.
Of course, you’ll need to keep a record and bring a list of all the medications you’ve taken, including prescription and over-the-counter drugs.
What should I do if I miss a dose?
If you forget to take a dose, take it as soon as possible.
But if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time.
Do not take double the prescribed dose.
Elbonix side effects
Common side effects in adults when used to treat chronic ITP are: nausea, diarrhea, infectious upper respiratory tract infection, vomiting, ALT elevation, muscle pain, and urinary tract infection.
In pediatric patients 1 year of age and older on ITP treatment, the most common adverse reactions were: upper respiratory tract infection and nasopharyngitis.
For patients with chronic thrombocytopenia associated with hepatitis C, the most common adverse reactions are: anemia, fever, fatigue, headache, nausea, diarrhea, decreased appetite, flu-like illness, asthenia, insomnia, cough, pruritus, chills, myalgia, alopecia and peripheral edema.
In patients with severe aplastic anemia, the most common adverse reactions are: nausea, fatigue, cough, diarrhea and headache.
What other medicines does Elbonix interact with?
Some medicines can make them much less effective when taken at the same time. If you take any of the following medicines, take your dose 2 hours before or 4 hours after you take the other medicine.
- An antacid.
- Take a vitamin or mineral supplement that contains aluminum, calcium, iron, magnesium, selenium, or zinc.
- Tell your doctor about all your other medicines, especially:
- A blood thinner–warfarin, Coumadin, Jantoven.
- Cholesterol medication – atorvastatin, ezetimibe, fluvastatin, pitavastatin, pravastatin, rosuvastatin hoặc simvastatin.
This list is not exhaustive. Other drugs may affect Elbonix, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Health conditions that affect the use of Elbonix
Pregnancy: There are no adequate and well-controlled studies with the use of Eltrombopag during pregnancy. So tell your doctor if you are pregnant or plan to become pregnant.
Lactation: You should not breast-feed while using this medicine.
Pediatric Use: Safe and effective use in pediatric patients 1 year of age and older with chronic ITP.
Use in the elderly: There were no differences in safety or efficacy for young patients in placebo-controlled trials, but a higher sensitivity in some older subjects cannot be ruled out. Care should be taken when using the drug,
Hepatic impairment: Liver failure affects exposure to Eltrombopag. Reduce the initial dose of Eltrombopag in patients with chronic ITP (adult and pediatric patients 6 years of age and older only) or severe aplastic anemia with concomitant hepatic impairment (Child-Pugh Class A, B, C). No dose adjustment is required for patients with chronic hepatitis C and liver failure.
Renal Impairment: No initial dose adjustment of Eltrombopag is required for patients with renal impairment. Closely monitor patients with impaired renal function while taking Eltrombopag.
How to store Elbonix?
- You should store the medicine at room temperature, in a cool, dry place, away from direct sunlight.
- You should not store the medicine in the refrigerator.
- Keep the medicine out of the reach of children.
- Do not throw medicine down the toilet or plumbing.
How much does Elbonix cost?
How much does Elbonix drug cost? Please COMMENT below or Contact ThuocLP Vietnamese Health 0933049874 (Zalo/ Facebook/ Viber/ Whatsapp) to buy and sell brand-name drugs in Ho Chi Minh City, Hanoi, Da Nang City, Can Tho City,… nationwide.
Note: The above article about Elbonix related to the effects of the drug and how to use it for the purpose of sharing knowledge, introducing information about the drug for medical staff and patients to refer to. Each case and location will have its own prescription and treatment. Patients must not arbitrarily use drugs, all information on drug use must be prescribed by a specialist doctor.
Reputable source ThuocLP Vietnamese: Elbonix medicine 25mg & 50mg – Treatment of thrombocytopenia bleeding
Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.