Do you need to know the price of Dostinex 0.5mg Cabergoline to treat infertility in women with high Prolactin or pituitary tumor? How to use or use Cabergoline 0.5mg , where to buy? index-china is a trading site specializing in Dostinex 0.5mg medicine in Ho Chi Minh City, Hanoi, Da Nang, Can Tho … and nationwide.
Dostinex medicine 0.5mg Cabergoline treats infertility in women with high Prolactin or pituitary tumors
- Generic brand name: Dostinex 0.5mg
- Active ingredient: Cabergoline
- Manufacturer: Pfizer
- Content: 0.5mg
- Form: Tablets
- Package: Box of 8 tablets
What is prolactin? How to lower Prolactin in women
- Prolactin (PRL), also known as luteotropic or luteotropin hormone, is a protein that plays a role in allowing mammals to produce milk.
- They are secreted from the pituitary gland in response to eating, mating, estrogen treatment, ovulation, and nursing.
- Prolactin also plays an essential role in metabolism, regulation of the immune system, and pancreatic development.
Information about Dostinex 0.5mg Cabergoline
Dostinex or Cabergoline is an ergot de seigle and an agonist selective dopamine D2 receptor, a potent inhibitor of prolactin secretion from the hypothalamus (hypophyse).
In addition to the treatment of Parkinson’s disease, cabergoline is also used to treat hyperprolacteinemia (hyperprolacteinemia).
It can also be used to treat infertility in women with high prolactin in the blood.
Dosage and Administration Dostinex 0.5mg
Oral dose
- Adults: Starting 0.25 mg orally 2 times a week, increase the dose gradually each 0.25 mg dose for 1 dose and do not change the dose less than 4 weeks until the dose to 1 mg orally 2 times a week. Once the weekly dose showed an efficacy of about 0.5-3 mg / week, prolactin levels would normalize in 73% of patients, and tumor size decreased by an average of 31% (range 5-95%). . Discontinuation may be considered after 6 months with acceptable serum prolactin levels. Regularly check prolactin levels to see if you should resume treatment with cabergolin.
- Children: safety and effectiveness have not been determined.
Vaginal dose
Adult women: There are reports that a 0.5 mg vaginal dose 2 to 5 times per week may be effective for normalizing prolactin levels for people who are intolerant to dopamine agonists. The lowest dose is needed to control symptoms.
Dose side effects dostinex 0.5mg : nausea, dizziness headache, constipation, weakness, fatigue, abdominal pain and drowsiness
How to use Dostinex
- Take this medication by mouth with or without food, usually twice a week or as directed by your doctor.
- The dosage is based on your medical condition and response to treatment (prolactin level). Your doctor will start with a low dose and slowly increase the dose over several months to help reduce side effects. Follow your doctor’s instructions carefully.
- Take this medication regularly to get the most benefit from it. To help you remember, mark the days on the calendar when you need to take your medication.
Tell your doctor if your condition persists or worsens.
Prolactin levels under normal physiological conditions
The level of prolactin in the blood of normal healthy people: non-pregnant women and normal healthy men is as follows:
- In normal healthy, non-pregnant adult women, prolactin level in the blood is 127-637 µU / mL, in pregnant women is 200 – 4500 µU / mL and in menopausal women is 30-430 µU / mL; in normal men, 98 – 456 6U / mL.
- The level of prolactin blood varies markedly throughout the day, gradually increasing during sleep and peaking in the morning. Prolactin in the blood has a half-life of only about 20-30 minutes. Therefore, the best time to take a prolactin blood test is about 3-4 hours after waking up.
- The level of prolactin in the blood can also increase in a number of normal physiological conditions, such as after a high meat meal, after intercourse, stimulation of the nipples, after exercise or when under stress (stress).
- In pregnant and lactating women, the level of prolactin in the blood increases physiologically.
How to maintain a stable concentration of Prolactin
- Prolactin levels affect the level of sex hormones – estrogen in women and testosterone in men. The effects of high Prolactin levels in women can lower estrogen levels and reduce libido. High prolactin also prolongs recovery time after intercourse.
- In fact, the high Prolactin causes the neurotransmitter Dopamine to decrease, the signals cannot reach other neurons, which directly affects the mood in the negative direction. In contrast, Dopamine is a Prolactin inhibitor. In addition, high prolactin can reduce your fertility.
- However, there are some drugs that help lower Prolactin levels such as Cabergoline (Dostinex) and bromocriptene, but it is full of side effects such as nausea, constipation, dry mouth, heart palpitations. If you intend to use the drug, consult a doctor.
Dostinex side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; shortness of breath; swelling of your face, lips, tongue or throat.
Stop using Dostinex and call your doctor right away if you have serious side effects such as:
- feeling short of breath on exertion;
- chest discomfort, dry cough or hacking;
- feeling weak or tired, anorexia, rapid weight loss;
- feeling like you may faint;
- low back pain;
- urinating less than usual or not at all;
- swelling in your ankles or feet.
Less serious side effects may include:
- nausea, vomiting, stomach ache, flatulence, indigestion, constipation;
- headache, depressed mood;
- dizziness, a feeling of rotation;
- drowsiness, suspense;
- Flushing;
- numbness or teasing sensation;
- Dry mouth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
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Caution before using Dostinex
You should not use this medication if you are allergic to Dostinex or if you have:
- uncontrolled high blood pressure (hypertension);
- pregnancy-induced hypertension, including eclampsia and pre-eclampsia;
- a history of heart disease or shortness of breath;
- if you have ever had a heart valve disorder;
- if you are allergic to any ergot medicine such as ergotamine (Ereimar, Cafergot, Migergot), dihydroergotamine (DHE 45, Migranal), ergonovine (Ergotrate) or methylergonovine (Methergine).
To make sure you can safely take Dostinex, tell your doctor if you have any other conditions:
- liver failure;
- heart disease;
- a respiratory disorder.
Dostinex is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether Dostinex passes into breast milk or whether it could harm a nursing baby. You should not breast-feed while you are using Dostinex.
Watch the video Dostinex 0.5mg
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Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Medical Certificate:
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.
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