Drug information Cymbalta 30mg, 60mg Duloxetine to treat depression
|30mg & 60mg
|Box of 28 capsules
What is Cymbalta?
Cymbalta contains the active ingredient Duloxetine which is a serotonin and norepinephrine reuptake inhibitor (SSNRI) antidepressant.
Medicines affect chemicals in the brain that may be out of balance in people with depression. It is also used to treat general anxiety disorder in adults and children 7 years of age and older.
What is Duloxetine’s mechanism of action?
Active ingredient duloxetine , is a serotonin-noradrenaline reuptake inhibitor. It works by blocking the neurotransmitter 5-hydroxytryptamine (also called serotonin) and noradrenaline from being returned to nerve cells in the brain and spinal cord.
Neurotransmitters are chemicals that allow nerve cells to communicate with each other. By blocking their reuptake, duloxetine increases the number of these neurotransmitters in these interneurons, increasing the level of cell-to-cell communication.
Since these neurotransmitters are involved in maintaining high mood and reducing pain, blocking their reuptake into nerve cells may improve symptoms of depression, anxiety, and depression. anxiety and neuropathic pain.
What is cymbalta used for?
- It is used to treat major depressive disorder, diabetic peripheral neuropathy (neuralgia caused by diabetes), and generalized anxiety disorder (excessive anxiety).
- Cymbalta belongs to a class of drugs called Serotonin and Noradrenaline reuptake inhibitors (SNRIs).
Who should not take Cymbalta?
- Hypersensitivity to the active substance or to any of the excipients.
- Concomitant use of Cymbalta with non-selective, irreversible monoamine oxidase inhibitors (MAOIs) is contraindicated.
- Liver disease leads to liver failure.
- The drug should not be used in combination with fluvoxamine, ciprofloxacin or enoxacin (i.e. a strong CYP1A2 inhibitor) because this combination increases plasma concentrations of the active substance.
- Severe renal impairment (creatinine clearance <30 ml/min).
- The initiation of drug therapy is contraindicated in patients with uncontrolled hypertension, which may place the patient at potential risk of hypertensive crisis.
Precautions while you are taking Cymbalta
Tell your doctor if you have or have had any of the following problems:
- Glaucoma disease.
- High Blood Pressure.
- Heart problems.
- Kidney problems because you may need to take Cymbalta at a lower dose.
- Bipolar disorder.
Effects on pregnancy or lactation.
- Your doctor can discuss with you the risks and benefits involved.
- If the drug is taken during pregnancy, you should be careful, especially late in pregnancy. Temporary withdrawal symptoms have been reported rarely in neonates following maternal use during the third trimester of pregnancy.
Dosage and how to use Cymbalta?
Dosage of Cymbalta
- The usual recommended dose for depressive disorder or diabetic peripheral neuropathy is one 60 mg tablet once daily.
- The recommended dose for generalized anxiety disorder is between 30mg and 120mg once daily.
- If you have severe kidney disease, the recommended starting dose of Cymbalta is one 30mg tablet once a day.
How to take medicine
- For depression, anxiety, and nerve pain, you’ll usually take the medication once a day.
- For urinary incontinence, you will usually take Cymbalta twice a day.
- Swallow the capsule whole with a glass of water or juice. Don’t chew them.
- You can take the medicine with or without food, but it’s best to take it at the same time each day.
- Consider using a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication. You can also ask a family member or friend to remind you to make sure you are taking your medication.
What to do if you miss a dose?
- If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.
- If not, take it as soon as you remember and then go back to taking it as usual.
- Do not take a double dose to make up for the dose you missed.
- If you are not sure what to do, ask your doctor or pharmacist.
- If you have trouble remembering to take your medicine, ask your pharmacist for some suggestions.
What to do if you overdose?
- Immediately call your doctor, or go to the nearest hospital, if you think you or anyone else may have taken too much Cymbalta.
- Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
- Symptoms of overdose may include drowsiness, seizures, and vomiting. Symptoms may also include some or all of the following: feeling confused, feeling restless, sweating, shaking, shaking, hallucinations, muscle twitching, heart palpitations.
Cymbalta drug side effects
Cymbalta may cause side effects in some people. But most people have no side effects or only side effects.
Common side effects: trouble sleeping, headache, feeling dizzy, blurred vision, constipation or diarrhea, feeling or being sick (nausea or vomiting), dry mouth, sweating, fatigue, increased appetite than usual and lose weight, Feeling less interested in sex, or having problems keeping an erection or reaching orgasm.
Serious side effects:
- Chest tightness or difficulty breathing.
- Any bleeding that is very bad or you can’t stop, such as a cut or nosebleed that doesn’t stop within 10 to 15 minutes.
- Painful erections that last more than 4 hours – this can happen even if you’re not having sex.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
What other drugs may interact with Cymbalta?
Many drugs can interact with duloxetine. Not all possible interactions are listed here. Tell your doctor about all of your current medicines and any you start or stop using, especially:
- Any other antidepressant.
- Tryptophan (sometimes called l-tryptophan).
- An amphetamine – adderall, focalin, vyvanse, ritalin, concerta, strattera, and others.
- An antibiotic–ciprofloxacin, enoxacin.
- A blood thinner–warfarin, coumadin, jantoven.
- heart rhythm medicine–flecainide, propafenone, quinidine, and others.
- Opioids – fentanyl , tramadol.
- Medicines to treat mood disorders, thought disorders, or mental illness–buspirone, lithium, thioridazine and many others.
- migraine medicine–sumatriptan, rizatriptan, zolmitriptan, and others.
This list is not exhaustive and many other drugs may interact with Cymbalta. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any health care provider who treats you.
Cymbalta drug storage
- Store the medicine in the original package to protect it from moisture. Do not store above 30°C.
- Do not use the medicine after the expiration date indicated on the carton.
- Keep the medicine in a safe place. Keep out of reach of children and pets.
How much does Cymbalta cost? Where to buy medicine?
How much does Cymbalta Duloxetine cost? Please COMMENT below or Contact 0933049874 (Zalo/ Facebook/ Viber/ Whatsapp) to buy and sell brand-name drugs in Ho Chi Minh City, Hanoi, Da Nang City, Can Tho City,… nationwide.
The above article is for reference only and is not a substitute for medical diagnosis or treatment. Readers should only follow the instructions of the doctor who is treating you, Index-China disclaims responsibility if problems occur.
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Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.