Chlorasp 2mg What is Chlorambucil?
Chlorasp drug has the main active ingredient Chlorambucil 2mg. It is used to treat certain types of chronic lymphocytic leukemia. It is also used to treat non-Hodgkin’s lymphoma (NHL) and Hodgkin’s disease
Chlorambucil is an alkylating, cytotoxic, antitumor drug that forms covalent bonds with nucleic acids, disrupts DNA strands, and blocks antibody production.
Information about Chlorasp 2mg Chlorambucil treats blood cancer, lymphoma
- Brand Name: Chlorasp.
- Active ingredient: Chlorambucil.
- Manufacturer: SP Accure.
- Content: 2mg.
- Form: tablets.
- Packaging: box of 30 tablets
Chlorambucil’s mechanism of action
The active ingredient chlorambucil acts as a double alkylating agent.
In addition to interfering with DNA replication, Chlorambucil induces cell death through the accumulation of cytosolic p53 and subsequent activation of an apoptosis promoter.
Indications for the treatment of Chlorasp
- Indications for the treatment of chronic lymphocytic leukemia.
- Treatment of malignant lymphoma (lymphoma, giant follicular lymphoma and Hodgkin’s disease).
Contraindications to treatment
- Patients with hypersensitivity to the active substance Chlorambucil or to other ingredients contained in the drug Chlorasp.
- Patients with severe bone marrow failure, porphyrin metabolism disorders.
- People with asthma.
- Patients with an enlarged prostate gland.
- Women who are pregnant, or during lactation.
Dosage of Chlorasp 2mg
Dosage for adults
The usual dosage for lymphatic disorders is 1 – 6 tablets per day per day.
Treatment of Hodgkin’s disease: dosage 0.2mg/kg/day; period from 4 to 8 weeks.
Treatment of Hodgkin lymphoma: 0.1-0.2mg/kg/day for 4-8 weeks.
Treatment of chronic lymphoid leukemia: 0.15mg/kg/day until the white blood cell count drops to 10,000 per microliter. Four weeks after the end of the first course of treatment, treatment can be continued at a dose of 0.1 mg/kg/day.
Membranous nephropathy with idiopathic nephrotic syndrome: Dosage is 0.2 mg/kg/day and is administered alternately in the second, fourth, and sixth months, along with corticosteroids at the first, third, and third months. year. The duration of treatment is usually 6 months.
Dosage for children: Chlorasp The safety and effectiveness of the drug have not been established in children.
How to use the drug?
- Chlorasp is taken orally and should be taken daily on an empty stomach (at least one hour before a meal or three hours after a meal).
- Swallow the tablet whole; Do not break, crush or chew the tablet.
Chlorasp side effects
Common side effects when starting treatment with Chlorasp 2mg:
- Anemia, leukopenia, thrombocytopenia, lymphocytopenia, neutropenia.
- Irreversible bone marrow failure, bone marrow suppression.
- Nausea, vomiting, diarrhea.
- Oral ulcers caused by drug exposure.
In addition, some other less common side effects have been recorded:
- Tremor, muscle tremors, hallucinations.
- Allergies, urticaria, angioedema.
- Toxic liver, jaundice.
If the patient experiences any of the above effects, they should immediately take them to the nearest hospital for timely treatment.
Precautions while using Chlorasp
Tell your doctor and pharmacist if you are allergic to chlorambucil, other alkylating agents such as: bentamustine (Treanda), busulfan (Myleran, Busulfex), carmustine (BiCNU, Gliadel Wafer), cyclophosphamide (Cytoxan), ifosfamide ( Ifex), lomustine (CeeNU), melphalan (Alkeran), procarbazine (Mutalane), or temozolomide (Temodar).
Tell your doctor if you have taken Chlorasp before, but your cancer has not responded to the medicine. Your doctor will probably ask you not to take the medicine.
You have had radiation or other chemotherapy within the past 4 weeks.
You have ever had a seizure or a head injury.
Effects on pregnant & lactating women
Pregnancy: Chlorambucil is a cytotoxic and cytotoxic substance and therefore has teratogenic potential, so its use is contraindicated during pregnancy.
Lactation: Women taking Chlorasp should not breast-feed.
Drug interactions with Chlorasp 2mg Chlorambucil
Live attenuated vaccines: Risk of fatal general vaccine disease Contraindicated in combination during chemotherapy and for 6 months after stopping chemotherapy.
Combinations not recommended
Phenytoin, fosphenytoin: Risk of seizure onset due to decreased gastrointestinal absorption of phenytoin alone by cytotoxic agents, or risk of increased toxicity or loss of cytotoxic effect due to increased metabolism in liver by phenytoin or fosphenytoin.
Olaparib: Risk of increased myelosuppressive effects of cytotoxic agents.
Combinations to watch out for when using
Vitamin K antibiotics: Increased risk of thrombosis and bleeding in tumor conditions. In addition, there may be an interaction between VKA and chemotherapy. Check INR more often.
Immunosuppressants: Excessive immunosuppression with risk of pseudo-lymphoma.
Flucytosine: Increased risk of hematologic toxicity.
How much does Chlorasp 2mg cost?
To know the price of the drug Chlorasp how much? Please COMMENT below or Contact 0933049874 (Zalo/ Facebook/ Viber/ Whatsapp) to buy and sell brand-name drugs in Ho Chi Minh City, Hanoi, Da Nang City, Can Tho City,… nationwide.
How to store medicine?
- You should store the medicine at room temperature, in a cool, dry place, away from direct sunlight.
- You should not store the medicine in the refrigerator.
- Keep the medicine out of the reach of children.
- Do not throw medicine down the toilet or plumbing.
The above article is for reference only and is not a substitute for medical diagnosis or treatment. Readers should only follow the instructions of the doctor who is treating you, Index-China disclaims responsibility if problems occur.
Reference source ThuocLP Vietnamese: Chlorasp medicine 2mg Chlorambucil for blood cancer treatment
Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.