Cellcept 250mg Mycophenolate mofetil prevents organ transplant rejection

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CellCept 250mg Mycophenolate mofetil prevents organ transplant difficult to treat

• Brand name: Cellcept 250mg
• Active ingredient: Mycophenolate mofetil
• Content: 250mg
• Form: Tablets
• Package: 1 box of 100 tablets
• Manufacturer: Roche
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What is Cellcept?

• CellCept (mycophenolate mofetil) weakens your body’s immune system, to help it not “reject” a transplant organ like the kidneys. Organ rejection occurs when the immune system considers the new organ to be an aggressor and attacks it.
• CellCept is used with other medicines to prevent organ rejection after kidney, liver or heart transplant.
• CellCept is often used with cyclosporine (Sandimmune, Neoral) and a steroid drug.

Assign the drug CellCept

• CellCept is indicated in combination with ciclosporin and corticosteroids in the treatment of prophylaxis of acute graft rejection in patients undergoing kidney, heart or liver transplantation.

The mechanism of action of  Mycophenolate mofetil

The active substance in CellCept, mycophenolate mofetil, is an immunosuppressant. In the body, it is converted to mycophenolic acid, blocking an enzyme called ‘inosine monophosphate dehydrogenase’.

This enzyme is important for DNA formation in cells, especially in lymphocytes, a type of white blood cell that is involved in transplant rejection.

By blocking the production of new DNA, CellCept reduces lymphocyte proliferation. This makes them less effective at recognizing and attacking transplanted organs, reducing the risk of organ rejection.

Dosage of Cellcept 25 0mg

• CellCept should be used concomitantly with cyclosporin & corticosteroids.
• Oral or intravenous route when patients can not drink.
• Dilute with 5% Dextrose infusion to reach 6 mg / mL, slow intravenous infusion for at least 2 hours.
• Prevention of renal transplant rejection: 1 gx 2 times / day.
• Prevention of heart transplant waste: 1.5 gx 2 times / day.
• Prevention of liver transplant rejection: 1.5 gx 2 times / day.
• Treatment of organ transplant rejection difficult to treat: 1.5 gx 2 times / day.
• Patients with neutropenia: discontinuation / dose reduction.
• Elderly: prophylactic dose of liver & kidney transplantation: not adjusted.
• Severe renal insufficiency: no more than 1 gx 2 times / day with kidney transplantation;
• Liver failure or after kidney transplantation with slow recovery of renal function: no dose adjustment.

How to take CellCept

• Oral CellCept is usually taken twice a day on an empty stomach.
• Try to take this medication at the same time each day, with your doses about 12 hours apart.
• Do not break, chew, crush, or open a CellCept capsule or tablet. Swallow whole.
• Follow the directions on the prescription label carefully. Do not use more or less CellCept than prescribed.

Contraindicated drug cellcept

• CellCept should not be used in patients with hypersensitivity to mycophenolate mofetil, mycophenolic acid or to any of the drug excipients.
• CellCept should not be used for women of childbearing potential who do not use effective contraception.
• CellCept treatment should not be started in women who are likely to become pregnant but do not provide pregnancy test results to exclude unintended use during pregnancy.
• CellCept should not be used during pregnancy unless appropriate alternative treatments are available to prevent transplant rejection.
• CellCept is not recommended for women who are breastfeeding.

Side effects of the drug Cellcept

Get emergency medical help if you have signs of an allergic reaction to CellCept: hives; shortness of breath; swelling of your face, lips, tongue or throat.

CellCept can affect your immune system and can cause some white blood cells to grow out of control. Call your doctor right away if you have:

• fever, swollen glands, mouth sores, cold or flu symptoms, headache, earache;
• stomach pain, vomiting, diarrhea, weight loss;
• weakness on one side of the body, loss of muscle control;
• confusion, problem thinking, loss of interest in things that often interest you;
• pain or burning when you urinate;
• Pain around the kidney transplant;
• swelling, warmth, redness or running around skin wounds;
• a new skin lesion, or a changed mole size or color.

Also call your doctor right away if you have:

• bloody stools, coughing up blood or vomiting that looks like coffee grounds;
• easy bruising, nosebleeds, bleeding gums or other abnormal bleeding;
• signs of hypertension such as severe headache, blurred vision, rushing in the neck or ears, anxiety, nosebleeds;
• signs of low blood cell counts include: fever, chills, fatigue, flu-like symptoms, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, colds feeling lightheaded or short of breath.

Common CellCept side effects may include:

• stomach pain, nausea, vomiting, diarrhea, constipation;
• swelling in your ankles or feet;
• rash;
• headache, dizziness, shaking;
• fever, sore throat or other signs of infection;
• low blood cell count;
• increased blood pressure or heart rate.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

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Precautions before using the drug Cellcept

• This medicine may cause miscarriage or birth defects when used during pregnancy. Both men and women using Cellcept should use effective contraception to prevent pregnancy.
• Talk to your doctor about the risks and benefits of Cellcept. This medication may affect your immune system.
• Cellcept can cause your body to produce too many white blood cells. This can lead to cancer, a serious brain infection that causes disability or death or a viral infection that causes kidney failure.
• Have digestive system disease; genetic & rare hypoxanthin-guaninephosphoribosyl-transferase (HGPRT) (Leseh-Nyhan and Kelley-Seegmiller syndrome); Post-transplant patients with renal function recover slowly. Pregnancy, lactation.

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• How much does Mycophenolate Cellcept cost 250mg?
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