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Casodex medicine 50mg Bicalutamide treats prostate cancer
- Brand name: Casodex 50mg
- Active ingredient: Bicalutamide
- Manufacturer: AstraZeneca
- Content: 50mg
- Form: Tablets
- Package: Box of 28 tablets
Hormone therapy for prostate cancer
- The male hormone is also called testosterone. In healthy people, this hormone helps stimulate prostate cells to grow. In the case of this gland cancer, testosterone also “helps” to enlarge the tumor. The goal of hormone therapy is to reduce stimulation of cancer cells by testosterone.
- Testosterone is produced by the testes, in response to another hormone called LH-RH (gonadotropin). The LH-RH hormone produced in the brain follows the blood flow to the testes to stimulate the testes to produce and release testosterone. Hormone treatment reduces the amount of testosterone in the blood, leaving the tumor free of food. Testicular surgery is also a method to reduce male hormones, that is, to eradicate the body from which testosterone is produced.
- Specifically, hormone treatment by using one or two drugs. One drug of choice was anti-LH-RH. This drug competes with the body’s LH-RH, inhibiting the release of LH-RH from the brain. The other drug of choice has an anti-androgenic effect, which is a male hormone, that inhibits the effects of testosterone in the prostate gland.
- Today, prostate cancer patients often prefer hormonal treatment over surgery because they find that castration of the testes is less aesthetic and unsafe. However, the efficacy and side effects of hormone therapy are about the same as castration. Both of these hormone treatments work to remove testosterone from stimulating cancer cells.
- Some prostate tumors that are unresponsive to hormone treatments include androgen-free and non -rogenic prostate cancers (male hormone). The main side effect of hormone treatments is breast enlargement and impotence.
- Anti-LH-RH medications, including leuprolide (Lupron) or goserelin (Zoladex), are injected every month at a health facility. Anti-androgen drugs including oral flutamide (Eulexin), bicalutamide (Casodex) are commonly used in combination with anti-LH-RH drugs. LH-RH antagonists usually work independently. In some cases, the doctor may prescribe a combination of anti-androgen drugs if the cancer is still progressing despite treatment with LH-RH. Hormone therapy may yield better results when combined with radiation therapy.
- Research is underway to determine if hormone therapy will increase the effectiveness of radiation therapy. Usually hormone therapy applies to patients with advanced or metastatic prostate cancer. Some tumors are localized but hormone therapy is indicated because the patient has severe medical conditions attached or they refuse other methods.
- According to statistics, newly developed hormone therapy for less than 10% of patients with local prostate cancer. Note: This is a temporary measure to control cancer but not completely cured.
Detailed information about the drug Casodex 50mg
Drug Casodex is what? What are the uses of Bicalutamide 50mg?
- Casodex (bicalutamide) is an anti-androgen substance (male hormone). It works in the body by blocking the action of androgens (male hormones).
- Casodex 50mg is used with other hormones to treat prostate cancer .
- Casodex may also be used for purposes not listed in this medication guide.
Important information about Casodex medication
- Casodex medicine is used to treat prostate cancer. Casodex medicine for women and children.
- Casodex may affect your liver. Call your doctor right away if you have nausea, upper abdominal pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
Before taking Casodex tablets 50mg
- You should not use Casodex if you are allergic to bicalutamide.
- Use effective birth control if your partner could be pregnant. The fetus may be harmed if the father is using bicalutamide. Keep using birth control for at least 130 days (about 19 weeks) after your last dose.
- Casodex is not for women or children.
- Although Casodex is not used for women, casodex can cause birth defects if a woman is exposed to it during pregnancy.
To make sure Casodex is safe for you, tell your doctor if you have:
- liver failure;
- Diabetes; or
- if you also take blood thinners (warfarin, Coumadin, Jantoven).
How to use Casodex 50mg Bicalutamide ?
- Take Casodex 50mg exactly as directed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
- Casodex is usually taken 1 time per day in the morning or evening. You can take medicine with or without food. Try to take the medication at the same time every day.
- Casodex is given as part of the treatment of prostate cancer in combination with another medication called a luteinizing (Loo-tee-in-ize-ing) hormone-releasing hormone, or LHRH. These medications prevent the testes from producing testosterone.
- Treatment with Casodex and LHRH is usually started at the same time. Follow your doctor’s instructions.
- LHRH is given as an injection or a small implant injected through a needle under the skin around your navel. LHRH injections are stated at intervals like once every 4 weeks. Follow your doctor’s instructions.
- You should not stop using Casodex unless your doctor tells you to do so.
- While using Casodex, you may need frequent blood tests at your doctor’s office.
- Store at room temperature away from moisture and heat.
- Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have questions.
T hips believe dose drug Casodex
Usual adult dosage for prostate cancer:
- 50 mg orally once a day, given at the same time each day.
- The recommended dose for Casodex treatment in combination with an LHRH analog is one 50 mg tablet once a day (morning or evening), with or without food. It is recommended that Casodex be taken concurrently every day. Treatment with Casodex should be started at the same time as treatment with an LHRH analog. If a dose of Casodex is missed, take the next dose at the scheduled time. Do not take the missed dose and do not double the next dose.
- Dose adjustment in Renal Impairment: No dose adjustment is necessary for patients with renal impairment
- Dose adjustment in liver failure: No dose adjustment is necessary for patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment (n = 4), although there was a 76% increase in the half-life (5.9 and 10.4 days for normal and impaired patients, respectively) of Positive enantiomer of bicalutamide without dose adjustment is required
What happens if I miss a dose?
- Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
- Call your doctor for instructions if you miss an appointment for your LHRH injection.
What happens if I overdose?
- Go to the nearest health care facility or call 115
What should i avoid while taking Casodex?
- Casodex may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake.
- Avoid exposure to sunlight or tanning beds. Bicalutamide can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
- Bicalutamide can pass into body fluids (urine, stool, vomit). Caregivers should wear rubber gloves when cleaning a patient’s body fluids, handling contaminated waste or washing or changing diapers. Wash hands before and after removing gloves. Wash soiled clothes and towels separately from other laundry.
T evil Casodex side
Get emergency medical help if you have any signs of an allergic reaction to Casodex: hives; shortness of breath; swelling of face, lips, tongue, or throat.
Call your doctor right away if you have:
- breast pain or swelling;
- blood in your urine;
- fever, chills;
- sudden chest pain or discomfort, wheezing, dry cough, feeling short of breath;
- low red blood cells (anemia) – pale skin, feeling light- headed or short of breath, fast heart rate, trouble concentrating;
- liver problems – nausea, upper abdominal pain, feeling tired, anorexia, dark urine, colored clay stools, jaundice (yellowing of the skin or eyes); or
- High blood sugar – increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss.
Common Casodex side effects may include:
- hot flashes;
- pain in the back, pelvis, or stomach;
- swelling in hands, ankles, or feet;
- increased nighttime urination;
- weakness, dizziness; or
- nausea, diarrhea, constipation.
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Other drugs affect the drug Casodex?
Other drugs may interact with bicalutamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Source: index-china.com
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Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Pharmacy.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Medical Certificate:
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.
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