Bosulif medicine 100mg Bosutinib treats leukemia. How much do you need to know about Bosutinib? You do not know where Bosulif medicine is sold? index-china is the address of selling and selling Bosulif medicine in Ho Chi Minh City, Hanoi, Da Nang, Can Tho … and nationwide.

Bosulif medicine 100mg Bosutinib treats leukemia

• Brand name: Bosulif
• Active ingredient: Bosutinib
• Content: 100mg
• Form: Tablets
• Package: 1 box of 28 tablets
• Manufacturer: Pfizer
• Bosulif Drug Prices: COMMENT below for prices OR Click on the link: https://thuoclp.com/chatFB type “Bosulif”

Indications for treatment of Bosulif drug

Bosulif contains active ingredient Bosutinib is a kinase inhibitor indicated for the treatment of adult patients:

• The newly diagnosed chronic leukemia called Philadelphia chromosome positive for myeloid leukemia (Ph + CML) in the chronic phase.
• Patients with Ph + CML in the chronic phase, accelerating or bursting stage (sudden onset of rapid growth of blood cancer in the rapid growth or the chronic phase) and taking medication for the treatment of Ph + CML Previous effects or inappropriate.

The mechanism of action of Bosutinib

• Bosutinib is a drug called protein tyrosine kinase inhibitor (TKI). Tyrosine kinases are proteins that act as chemical messengers to stimulate cancer cells to grow.
• Bosutinib inhibits a protein made by the Philadelphia chromosome CML cells. Blocking this protein prevents white blood cells from growing.
• Bosutinib is also a Src kinase inhibitor, including Src, Lyn and Hck. Bosutinib inhibited 16 of the 18 forms of imatinib-resistant BCR-ABL kinase expressed in myeloid cell lines in mice. Bosutinib does not inhibit the T315I and V299L mutant cells.

Contraindicated

• Hypersensitivity to the components of the drug Bosulif.
• Do not use for children under 18 years of age.
• Pregnant and lactating women.

Dosage and usage of Bosulif

Dosage recommended

• In the newly diagnosed chronic phase Ph + CML: 400 mg orally once a day.
• Chronic phase, accelerated or explosive Ph + CML with resistance or intolerance to previous therapy: 500 mg orally once a day with food.

Dosage adjustment:

• Consider increasing the dose by increasing 100 mg once daily to a maximum of 600 mg daily in patients who do not achieve complete hematological, cytological or molecular reactions and no adverse reactions 3 or greater at the recommended starting dose.
• Adjust dose reduction to 100mg daily for organ toxicity and impairment

Using

• Always take Bosutinib exactly as directed by your doctor.
• Bosutinib should be taken once a day with food.
• Bosutinib should be taken at approximately the same time each day to achieve the best effect.
• Do not crush, break or chew bosutinib tablets.
• If you miss a dose and continue for more than 12 hours until the next scheduled dose, you should skip the missed dose and continue taking the next scheduled dose.

Warnings and precautions when using Bosulif

• Rash: Some patients may have a rash, scaly skin or red pimples.
• Gastrointestinal toxicity: Diarrhea, nausea, vomiting and abdominal pain occur during Bosulif treatment.
• Bone marrow suppression: Thrombocytopenia, anemia and neutropenia occur during Bosulif treatment.
• Hepatotoxicity : Bosulif may cause elevated serum transaminase levels to damage the liver.
• Fluid retention: Fluid retention occurs with Bosulif and may manifest as pericardial effusion, pleural effusion, pulmonary edema or peripheral edema.
• Renal toxicity: A therapeutic decrease in the estimated glomerular filtration rate (eGFR) has occurred in patients treated with Bosulif.
• Heart problems: Bosulif can cause heart problems like heart failure.
• Embryotoxicity: Bosulif may harm an unborn baby when used in pregnant women.

Side effects of Bosulif

The most common side effects of Bosulif in people with newly diagnosed CML include:

• diarrhea
• nausea
• low platelet count
• rash
• Changing liver function tests

stomachache

The most common side effects of Bosulif in people with CML who no longer benefit or tolerate other treatments include:

• diarrhea
• nausea
• stomachache
• rash
• low platelet count
• vomit
• low red blood cell count
• tired
• fever
• ho
• headache
• Changing liver function tests
• swelling

Other drug interactions with Bosulif

The following active ingredients may increase the risk of side effects with Bosulif:

• Ketoconazole, itraconazole, voriconazole, posaconazole and fluconazole: are used to treat fungal infections.
• Clarithromycin, telithromycin, erythromycin and ciprofloxacin: are used to treat infections.
• Nefazodone: used to treat depression.
• Mibefradil, diltiazem and verapamil: used to lower blood pressure.
• Ritonavir, lopinavir / ritonavir, indinavir, nelfinavir, saquinavir, atazanavir, amprenavir, fosamprenavir and darunavir: are used to treat human immunodeficiency virus (hiv / aids).
• Boceprevir and telaprevir: used to treat hepatitis c.
• Aprepitant: used to prevent and control nausea and vomiting.
• Imatinib: used to treat a type of leukemia.
• Crizotinib: used to treat a type of lung cancer that is non-small cell lung cancer (NSCLC)

The following active ingredients may reduce the effectiveness of Bosulif:

• Rifampicin: used to treat tuberculosis.
• Phenytoin and carbamazepine: used to treat epilepsy.
• Bosentan: used to lower high blood pressure in the lungs.
• Nafcillin: an antibiotic used to treat infections.
• John’s wort: used to treat depression.
• Efavirenz and etravirine: used to treat hiv / aids infection.
• Modafinil: used to treat certain types of sleep disorders.

The following active ingredients may affect heart rate when taken with Bosulif:

• Amiodarone, disopyramide, procainamide, quinidine and sotalol: used to treat heart disorders.
• Chloroquine, halofantrine: used to treat malaria.
• Antibiotics clarithromycin and moxifloxacin: used to treat infections.
• Haloperidol: used to treat mental illness such as schizophrenia.
• Domperidone: used to treat nausea and vomiting or to stimulate breast milk production.
• Methadone: used to treat pain.

This is not a complete list of drugs that can interact with Bosulif. These drugs should be used with caution during your treatment with Bosulif. If you are taking any of them, tell your doctor.

Interact with food

• Do not take Bosulif with grapefruit or grapefruit juice, as it may increase the risk of side effects.

Preserving Bosulif medicine

• Store Bosulif at a temperature between 20 ° C and 25 ° C.
• Keep this medicine out of the reach of children and pets.

Drug Bosulif 100mg Bosutinib cost?

• How much does Bosutinib 100mg Bosutinib cost?
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Where is Bosulif 100mg from Bosutinib?

• Where is Bosulif 100mg Bosutinib medicine address?
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Note: Information about Bosulif 100mg Bosutinib medicine is for the purpose of sharing knowledge for reference only, patients are not allowed to use the drug on their own, all information on drug use must be directed by a qualified physician.

Source: index-china.com