Baraclude medicine 0.5mg Entecavir treats hepatitis B

Basic information about Baraclude 0.5mg Entecavir treatment of hepatitis B

• Brand Name: Baraclude .
• Active ingredient: Entecavir .
• Manufacturer: Bristol Myers Squibb Company.
• Content: 0.5mg.
• Form: Tablets.
• Packaging: Box of 3 blisters x 10 tablets.

What is Baraclude 0.5mg Entecavir?

Baraclude medicine contains the active ingredient Entecavir and belongs to a group of medicines called antivirals. It is used to treat adults infected with the hepatitis B virus.

How does Entecavir work?

The active ingredient entecavir inhibits the function of three activities of viral polymerase: (1) priming of the HBV polymerase, (2) reverse transcription of negative-stranded DNA from progenitor messenger RNA, and synthesis of positive-stranded HBV DNA.

Entecavir is a weak inhibitor of α, β, and δ cell DNA polymerases with K values ​​between 18 and 40 µM. In addition, high exposure to entecavir had no adverse effects related to γ ​​polymerase or mitochondrial DNA synthesis in HepG2 cells (Ki > 160 µM).

What does Baraclude do?

Baraclude is indicated for the treatment of chronic hepatitis B virus (HBV) infection in adults with:

• Compensated liver disease and evidence of active viral replication, elevated serum alanine aminotransferase levels, and histological evidence of active inflammation or fibrosis.
• Decompensated liver disease.

Who should not take the drug?

Hypersensitivity to the active substance or to any of the excipients of Baraclude.

Dosage and how to use Baraclude?

Dosage of Baraclude

Recommended dosage in adults

Compensatory liver disease

• The recommended dose of Baraclude for chronic hepatitis B virus infection in adults and adolescents receiving nucleoside inhibitor therapy and adolescents 16 years of age and older is 0.5 mg once daily.
• Dose recommendations for use in adults and adolescents (at least 16 years of age) with a history of hepatitis B while receiving lamivudine or lamivudine or known telbivudine-resistant variant rtM204I/V with or without rtL180M, rtL80I/ V, or rtV173L is 1 mg once daily.

Decompensated liver disease

The recommended dose for chronic hepatitis B virus infection in adults with decompensated liver disease is 1 mg daily.

Recommended dosage in children

Recommended dosage when using Baraclude 0.5mg solution (mL)

Weight (kg)	Patient has not received any treatment	Treatment with Lamivudine
10-11	3		6
11 – 14	4		8
14 – 17	5		ten
17 – 20	6		twelfth
20 – 23	7		14
23 – 26	8		16
26 – 30	9		18
Over 30	ten		20

How to use Baraclude?

• Take Baraclude exactly as it was prescribed for you. Follow all directions on your medication label and read all medication instructions or instruction sheets. Use the medication exactly as directed.
• Take on an empty stomach, at least 2 hours before or 2 hours after eating.
• Measure the liquid medicine carefully, using the dosing syringe with your medicine (not a kitchen spoon). Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
• Use regularly to get the most benefit and keep your condition from getting worse. Call your doctor if your hepatitis symptoms do not improve, or if they get worse.
• Do not change your dose or dosing schedule without your doctor’s advice. Everyone with HBV should be under the care of a doctor.
• Hepatitis B may become active or get worse in the months after you stop using Baraclude. You may need frequent liver function tests while using this medicine and for several months after your last dose.

What to do if you miss a dose of Baraclude medicine?

• If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.
• If not, get it as soon as you remember, and then come back and get it as usual.
• Do not take a double dose to make up for the dose you missed. This can increase your chances of getting an unwanted side effect. If you are not sure what to do, ask your doctor or pharmacist.
• If you have trouble remembering to take your medicine, ask your pharmacist for some suggestions and inform your doctor that you have missed a dose. It is very important not to miss your dose of Baraclude.

What happens if I overdose?

Seek emergency medical attention.

Precautions before you start taking Baraclude

Tell your doctor if you are allergic to:

• Any other medicines you have been given or purchased.
• Substances such as foods, preservatives or dyes.

Symptoms of a serious allergic reaction may include: chills, fever, heart palpitations, wheezing or coughing, trouble breathing, dizziness, flushing, sweating, and swelling of the face, tongue, or other parts of the body. other parts of the body.

Effects on pregnant or lactating women

• Restrictions on the use of Baraclude in pregnant women. Therefore, it should not be used during pregnancy unless it is clearly needed.
• If there is an urgent need to consider using Baraclude during pregnancy, your doctor will discuss the benefits and risks of taking it with you. If you take Baraclude while you are pregnant, talk to your doctor.
• It is not known whether the active ingredient Entecavir passes into breast milk. Therefore, to avoid possible side effects in nursing infants, mothers should stop breastfeeding if they are taking the drug.

Have HIV and you are not currently receiving HIV treatment

• Baraclude 0.5mg is not recommended in patients with both HIV and hepatitis B and who are not currently receiving anti-HIV therapy.
• Medications that can affect your HIV virus can affect future treatment options for HIV.

Side effects of Baraclude 0.5mg

Like all medicines, this medicine can cause side effects, although not everyone gets them.

Patients treated with this medicine have reported the following side effects:

Adults

• Common (at least 1 in 100 patients): headache, insomnia (inability to sleep), fatigue (extreme fatigue), dizziness, somnolence (drowsiness), vomiting, diarrhea, nausea , indigestion (dyspepsia) and elevated liver enzymes.
• Uncommon (at least 1 in 1,000 patients): rash, alopecia.
• Rare (at least 1 in 10,000 patients): severe allergic reaction.

Children and adolescents

• The side effects experienced in children and adolescents were similar to those in adults as described above with the following differences:
• Very common (at least 1 in 10 patients): low levels of neutrophils (a type of white blood cell, important in fighting infection).

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed above.

Drug interactions with Baraclude 0.5mg Entecavir

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Preservation of drugs

• Keep Baraclude out of the sight and reach of children.
• Do not use this medicine  after the expiration date stated on the bottle, blister or carton after EXP. That expiration date refers to the last day of that month.
• Blister package: do not store above 30°C. Store in original carton.
• Bottle package: do not store above 25°C. Hold bottle tightly.
• Do not dispose of any medication through sewage or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

The above article is for reference only and is not a substitute for medical diagnosis or treatment. Readers should only follow the instructions of the doctor who is treating you, Index-China disclaims responsibility if problems occur.

Index-China

See also: https://index-china.com/product/baraclude-medicine-entecavir/

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