Adcetris medicine 50mg Brentuximab treatment of Hodgkin’s lymphoma

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Adcetris medicine 50mg Brentuximab treat Hodgkin lymphoma (cancer of the lymphatic system)

• Brand name: Adcetris 50mg.
• Active ingredient: Brentuximab vedotin.
• Content: 50mg.
• Form: Concentrated powder for infusion solution.
• Package: 1 bottle of 50mg.
• Manufacturer: Takeda.

Lymphoma

Lymphoma is a type of blood cancer that occurs in white blood cells, including:

• HL: Hodgkin lymphoma is a type of lymphoma that begins in the lymphatic system, usually in a lymph node. The disease can be found due to a swollen lymph node in the neck, chest or other areas.
• NHL: Non-Hodgkin’s lymphoma is a cancer of the lymphatic and immune system. NHL represents a group of cancers different from Hodgkin’s disease.

What is adcetris?

• Adcetris contains the active ingredient Brentuximab vedotin which is an anticancer, made up of a monoclonal antibody linked to a substance that destroys cancer cells. It is transferred to cancer cells by monoclonal antibodies. A monoclonal antibody is a protein that recognizes some cancer cells.
• Adcetris is used to treat advanced untreated classic Hodgkin lymphoma patients. Adcetris will be used in combination with doxorubicin, vinblastine and dacarbazine are other chemotherapy drugs used to treat Hodgkin lymphoma.
• Adcetris is also used to reduce the likelihood that classic Hodgkin lymphoma may recur or recur after stem cell transplantation or treatment with other cancer drugs.
• Adcetris is used to treat massive anaplastic lymphoma in the whole body found in the lymph nodes or throughout other parts of the body.
• Adcetris is also given after other treatments have failed.

Indications for the treatment of Adcetris

Hodgkin’s lymphoma

• Have just been diagnosed with anaplastic large lymphoma system (sALCL) or other peripheral CD T lymphoma (PTCL).
• Cancer relapses major primary anaplastic osteoblastoma (pcALCL) or mycosis (MF).
• Anaplastic systemic large cell recurrence cancer (sALCL).

Non-Hodgkin’s lymphoma

• Cancer in stage 3 or 4 has just been diagnosed.
• There is a high risk of cancer coming back or worsening after stem cell transplantation (SCT).
• Non-Hodgkin’s lymphoma recurs.

Contraindicated

Contraindications to the use of Adcetris with bleomycin carcinogen due to an increased risk of pulmonary toxicity

Do not use in cases of allergy or hypersensitivity to any component of adcetris.

The mechanism of action of Brentuximab

Brentuximab is a monoclonal antibody. Monoclonal antibodies (MAB) are copies of a single antibody. They are made in a laboratory.

Monoclonal antibodies search for cancer cells by targeting specific proteins on the cell surface.

Brentuximab targets a protein called CD30 found on Hodgkin lymphocytes and anaplastic lymphocytes. Brentuximab sticks to the CD30 protein and injects the drug into the cell then kills the cell.

Dosage and Administration

Adcetris should be administered under the supervision of a physician experienced in the use of anticancer agents.

• The recommended dose is 1.8 mg / kg when administered intravenously over 30 minutes every 3 weeks.

Treatment should be continued until the disease progresses or the toxicity is not acceptable.

The course of treatment with Adcetris minimum 8 cycles and maximum 16 cycles about 1 year.

The cancer has not been treated

The recommended dose in combination with doxorubicin, vinblastine and dacarbazine chemotherapy is 1.2 mg / kg in the form of intravenous infusion for 30 minutes on days 1 and 15 of each 28-day cycle for 6 cycles.

After the first dose of Adcetris in combination with chemotherapy, your doctor may also give you a medicine that helps prevent the development or decrease the severity of neutropenia that increases the risk of infection.

How to use the drug Adcetris

• Use only Adcetris in the form of intravenous infusion.
• Adcetris should be administered via a specialized intravenous line and should not be mixed with other medicinal products
• The recommended dose of Adcetris is infused over 30 minutes.
• The dosage is based on medical condition, weight and response to treatment.
• Treat with brentuximab every 3 weeks up to 16 times, as long as it works. Therefore, the course of treatment takes up to 48 weeks almost a year.

If you miss a dose of adcetris : contact your doctor or pharmacist immediately to set up a new dosing schedule.

If using overdose : Contact emergency with your doctor or go to the nearest health department for timely assistance, avoiding possible adverse effects.

Important information to know when using adcetris

Adcetris can cause serious brain infections that can lead to disability or death. Call your doctor right away if you have problems with speech, thinking, vision or muscle movement.

Before using Adcetris, tell your doctor or pharmacist if you are allergic to adcetris or if you have any other allergies. This product may contain inactive ingredients, which may cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medicine, tell your doctor or pharmacist about your medical history, especially: kidney disease, liver disease.

Adcetris may make you more susceptible to infections or may aggravate any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that can spread to others such as chickenpox, measles, or flu. Consult your doctor if you have been exposed to an infection or for more details.

Do not vaccinate without a doctor’s consent. Avoid contact with people who have recently received live vaccines.

Before surgery, tell your doctor or dentist about all products you use including prescription drugs, over-the-counter medicines and herbal products.

Fertility, pregnancy and lactation

Fertility

Women of childbearing ability should use two effective methods of contraception during treatment with Adcetris and until 6 months after treatment.

Treatment with Adcetris has resulted in testicular toxicity, and may alter male fertility. Therefore, men who are being treated with this drug should keep sperm samples frozen and stored before treatment. Men being treated with this drug are advised not to father during treatment and until 6 months after the last dose.

Men and women should ask about reliable birth control forms while using this medicine and for 6 months after stopping treatment. If you are pregnant, talk to your doctor right away about the risks and benefits of this medicine.

Pregnant

You should not become pregnant while you are using Adcetris. It can harm an unborn baby.

Adcetris should not be used during pregnancy unless the benefits to the mother outweigh the potential risks to the fetus. If a pregnant woman needs treatment, should be clearly informed of the potential risk to the fetus.

Inform your doctor that you are pregnant while using Adcetris.

Breastfeeding

It is unknown whether this drug passes into breast milk. Because of the risk that can occur to a nursing infant, breastfeeding should not be done while using this medication. Consult a doctor before breastfeeding.

It is necessary to decide whether to stop breastfeeding or to stop using this therapy, taking into account the risk of breastfeeding to the child and the benefits of treatment for women.

Adcetris drug interaction

Some products that may interact with this medication include:

• bleomycin,
• Other drugs that weaken the immune system,
• increases the risk of infections such as natalizumab, rituximab.

Other drugs may affect the removal of Adcetris from your body, which may affect the way it works.

Drug interactions can change the way your medications work or increase your risk of serious side effects.

This document does not contain all possible drug interactions. Keep a list of all products you use including prescription drugs, over-the-counter medicines, and herbal products telling your doctor.

Do not start, stop or change the dosage of any medicine without your doctor’s approval.

Adcetris side effects

Side effects may vary if you are taking Adcetris with other cancer treatments.

Check with your doctor or nurse right away if any of the following side effects occur while taking Adcetris:

• Backache
• bleeding gums
• blood in urine or stool
• body ache
• bone pain
• burning, numbness, tingling sensation or pain sensation
• chills
• ho
• Tinnitus
• fever
• headache
• lost voice
• painful or difficult urination
• pale skin
• identify red spots on the skin
• stuffy or runny nose
• swelling, pain, or lymph nodes in the neck, armpits or groin
• chest tightness
• Breathing difficulties when exertion
• ulcers, sores or white spots in the mouth
• Unusual bleeding or bruising
• Unusual fatigue or weakness
• weakness in arms, hands, feet or feet

Side effects are rare

• Severe skin reaction
• High concentrations of uric acid
• Viral infection in the brain

Contact your doctor or nurse right away if any of your side effects become severe or if you show signs of an infection, including temperatures above 38 ° C.

Preserving the drug

• Store in the refrigerator (2 ° C-8 ° C). Do not freeze.
• Keep the vial in the original container to protect it from light.
• It is important to always check the product for storage instructions, or ask your doctor. To be safe, you should keep all medicines away from children and pets.
• Do not flush medication to the toilet or empty them unless instructed to do so. Proper disposal of this product when it expires or is no longer needed.

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