Omeprazole medicine: Uses, dosage and usage

omeprazole-medicine-uses-dosage-usage

What is Omeprazole?

Omeprazole medicine is a proton pump inhibitor that reduces the amount of acid produced in the stomach.

It is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess acid in the stomach.

It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

It can also be used with antibiotics to treat stomach ulcers caused by infection with the bacteria Helicobacter pylori (H. pylori).

The over-the-counter (OTC) omeprazole is used to help control heartburn that occurs 2 or more days per week. Over-the-counter omeprazole must be taken on a regular basis for 14 consecutive days.

Omeprazole drug information

  • Drug Name: Omeprazole 20 mg.
  • Registration Number: VD-20348-13.
  • Active ingredient – ​​Concentration/strength: Omeprazole – 20mg; 40mg.
  • Dosage form: Hard capsule.
  • Packing: Box of 3 blisters x 10 tablets, box of 10 blisters (tear blister) x 10 tablets, bottle of 14 tablets, 500 tablets.
  • Expiry date: 36 months.
  • Group: gastrointestinal drugs

Form and content:

  • Capsules 5mg, 10mg, 20mg, 40mg.
  • Suspension 25mg, 2.5mg, 10mg.

What does Omeprazole do?

Treatment of duodenal ulcer

  • Prevention of duodenal ulcer recurrence;
  • Treatment of stomach ulcers;
  • Prevention of recurrence of gastric ulcers;
  • In combination with appropriate antibiotics, eradication of Helicobacter pylori (H. pylori) in peptic ulcer disease ;
  • Treatment of NSAID-associated gastric and duodenal ulcers;
  • Prevention of NSAID-induced gastric and duodenal ulcers in at-risk patients;
  • Treatment of esophagitis caused by reflux;
  • Long-term management of patients with healed reflux esophagitis;
  • Treatment of symptomatic gastroesophageal reflux disease;
  • Treatment of Zollinger-Ellison syndrome.

Use for children

Children over 1 year old and ≥10 kg

  • Treatment of esophageal reflux.
  • Symptomatic treatment of heartburn and acid reflux in gastroesophageal reflux disease.

Children and adolescents over 4 years of age: in combination with antibiotics in the treatment of duodenal ulcers caused by H. pylori.

How does Omeprazole work?

The active ingredient Omeprazole, a racemic mixture of two enantiomers, reduces gastric acid secretion through a highly targeted mechanism of action.

It is a specific inhibitor of the acid pump in parietal cells. It is rapidly acting and provides control through reversible inhibition of gastric acid secretion in a once daily dose.

The active ingredient Omeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the intracellular tubules in parietal cells, where it inhibits the enzyme H + K + -ATPase – the acid pump.

This effect on the final step of gastric acid formation is dose dependent and highly effective in inhibiting both basal acid secretion and stimulated acid secretion, regardless of stimulus.

Who should not take the drug?

  • Hypersensitivity to omeprazole, substituted benzimidazole or to any of the excipients.
  • Omeprazole, like other proton pump inhibitors (PPIs) should not be used concomitantly with nelfinavir.

Dosage and how to use Omeprazole?

Dosage of Omeprazole

Dosage for adults

Usual Adult Dose for Duodenal Ulcer Disease: Take omeprazole 20mg once daily before meals. Most patients are treated within 4-8 weeks.

Usual Adult Dose for Peptic Ulcer Disease: Take omeprazole 40mg once daily before meals for 4 to 8 weeks.

Usual Adult Dose for Erosive Esophagitis : Take omeprazole 20mg once daily before meals. Dosage may be increased up to 40 mg daily based on desired clinical response and patient tolerability.

Studies on maintenance treatment of erosive esophagitis for up to 12 months have been completed.

Usual Adult Dose for Zollinger-Ellison Syndrome:

  • Initial dose: omeprazole 60mg orally once a day. Dosage should be tailored to the individual patient.
  • Maintenance dose: dose may be up to 120mg 3 times a day. Dosages above 80 mg per day should be divided into smaller doses.

Usual Adult Dose for Gastroesophageal Reflux Disease:

  • Initial dose: omeprazole 20mg orally once a day before meals for 4 to 8 weeks. Dosage can be increased to 40mg per day if necessary.
  • Maintenance dose: Long-term therapy with doses of 10-20mg daily may be required for maintenance treatment if the disease is long-lasting and this therapy appears to be relatively safe.

Usual Adult Dose for Multiple Endocrine Disease:

  • Initial dose: 60mg orally once a day before meals. Dosage may be adjusted based on the desired clinical response and patient tolerability.
  • Maintenance dose: dose may be up to 120 mg 3 times a day. Dosages above 80 mg per day should be divided into smaller doses.

Usual Adult Dose for Systemic Mast Cell Disease:

  • Initial dose: 60mg orally once a day before meals. Dosage may be adjusted based on the desired clinical response and patient tolerability.
  • Maintenance dose: dose may be up to 120mg 3 times a day. Dosages above 80mg per day should be divided into smaller doses.

Usual Adult Dose for Indigestion:

Prevent frequent heartburn: take omeprazole 20mg orally once a day, before meals, for 14 days.

Dosage for children

Usual pediatric dose for erosive esophagitis:

Drinking use:

Infants with gastroesophageal reflux disease (GERD): 0.7 mg/kg/dose once daily reduced gastric and esophageal pH time to less than 4, as well as the number of reflux episodes in 10 infants [mean PMA: 36.1 weeks, (34 to 40 weeks)] in one trial. Doses higher than 1-1.5 mg/kg/day have been reported

Children and adolescents 1 to 16 years of age with gastroesophageal reflux disease (GERD), ulcers, or esophagitis are recommended by the manufacturers when taking:

  • From 5 kg to less than 10 kg: 5 mg once daily.
  • From 10 kg to less than or equal to 20 kg: 10 mg once daily.
  • Over 20 kg: 20mg once daily.

Alternative dose:

  • Children 1 to 16 years: 1 mg/kg/dose once or twice daily.
  • Adjuvant treatment of Helicobacter pylori associated duodenal ulcers (in combination with clarithromycin or clarithromycin and amoxicillin) in children:
  • From 15 to 30 kg: 10mg 2 times a day.
  • Over 30 kg: 20mg 2 times a day.

Note: The safety and efficacy of using omeprazole in patients under 1 year of age and in children in addition to gastric reflux and maintenance therapy for erosive esophagitis have not been established.

Usual Pediatric Dose for Gastroesophageal Reflux Disease:

Drinking use:

Neonates with gastroesophageal reflux disease: 0.7 mg/kg/dose once daily reduced the duration of gastric and esophageal clearances to less than 4, as well as the number of reflux episodes in 10 infants. [mean PMA: 36.1 weeks, (34 to 40 weeks)] in one trial. Doses higher than 1-1.5 mg/kg/day have been reported.

Children and adolescents aged 1 to 16 years with gastroesophageal reflux disease, ulcers, esophagitis are recommended by the manufacturers:

  • From 5 kg to less than 10 kg: 5mg once a day.
  • From 10 kg to less than or equal to 20 kg: 10mg once daily.
  • Over 20 kg: 20mg once daily.

Alternative dose:

  • Children 1 to 16 years: 1 mg/kg/dose once or twice daily
  • Adjuvant treatment of duodenal ulcers caused by Helicobacter pylori (in combination with antibiotic therapy with clarithromycin or clarithromycin and amoxicillin) in children:
  • From 15 to 30 kg: 10mg 2 times a day.
  • Over 30 kg: 20mg 2 times a day.

How to take medicine

Omeprazole is taken orally, at least 1 hour before meals. You can also take an antacid with this medicine.

If you are taking mucocutaneous medications such as Sucralfate, take omeprazole about 30 minutes before sucralfate.

For suspension drugs: shake well before use.

For capsules: Swallow whole, do not chew, do not crush. However, if it is not possible to swallow the tablet whole, you can sprinkle the medicine in a spoonful of apple juice and swallow it without chewing.

If you are taking Omeprazole, do not take it for more than 14 days (unless directed by your doctor).

Contact a specialist soon if you notice that the disease does not improve after a period of treatment or becomes more serious. If heartburn persists after 14 days of taking the medication, see your doctor for more appropriate treatment.

Precautions while you are taking Omeprazol

You should not use omeprazole if you are allergic to it if you are also allergic to medicines such as: omeprazole, such as esomeprazole, lansoprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Protonix, and others;

You also take an HIV medicine that contains rilpivirine (such as Complera, Edurant, Odefsey, Juluca).

Ask your doctor or pharmacist if it is safe for you to use omeprazole if you have other medical conditions, especially:

  • Difficult or painful swallowing;
  • bloody or black stools, vomit that looks like blood or coffee grounds;
  • Ợ sour has lasted more than 3 months;
  • Frequent chest pain, heartburn accompanied by wheezing;
  • Unexplained weight loss;
  • Nausea or vomiting, stomach pain;
  • Liver failure ;
  • low levels of magnesium in the blood;
  • Osteoporosis or low bone mineral density (osteoporosis).
  • You’re more likely to break a bone in your hip, wrist, or spine when taking proton pump inhibitors long-term or more than once per day. Talk to your doctor about ways to keep your bones healthy.
  • Ask your doctor before using omeprazole if you are pregnant or breast-feeding.
  • Do not give this medicine to children without medical advice.

What other drugs may interact with Omeprazole?

Some drugs can interact with the stomach medicine Omeprazole:

  • Clopidogrel;
  • Rilpivirine, atazanavir and nelfinavir.

Drugs that interact with Omeprazole increase the risk of these side effects:

  • Citalopram;
  • Voriconazole;
  • Digoxin;
  • Saquinavir;
  • Phenytoin;
  • tacrolimus;
  • Warfarin;

Omeprazole stomach medicine may reduce the effectiveness of the treatment of medicines:

  • Ketoconazole;
  • Este ampicillin ;
  • Iron salts;
  • Mycophenolate mofetil (MMF);

The mechanism of action as well as the active ingredients of the stomach medicine Omeprazole is similar to that of Esomeprazole. Therefore, patients should be careful to avoid using drugs containing esomeprazole while using Omeprazole.

For pregnant & lactating women

There are not enough studies to determine the risks of taking this medicine during pregnancy or breast-feeding. Before taking medication, always consult with your doctor to weigh the benefits and risks.

Omeprazole side effects

Get emergency medical help if you have signs of an allergic reaction to omeprazole: hives; shortness of breath; swelling of the face, lips, tongue, or throat.

Stop using omeprazole and call your doctor at once if you have:

  • severe stomach pain, watery or bloody diarrhea;
  • New or unusual pain in your wrist, thigh, hip, or back;
  • Convulsions (convulsions);
  • kidney problems–little or no urinating, blood in your urine, swelling, rapid weight gain;
  • low magnesium–dizziness, irregular heartbeat, feeling restless, muscle cramps, muscle spasms, cough or choking feeling;
  • New or worsening symptoms of lupus – joint pain and a skin rash on your cheeks or arms that worsen in the sun.
  • Taking this medicine long-term can cause you to develop tumors in your stomach called adenomas. Talk to your doctor about this risk.
  • If you use omeprazole for longer than 3 years, you may develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.

Common side effects of omeprazole may include:

  • Stomach pain, flatulence;
  • Nausea, vomiting, diarrhea;
  • Headache.

This is not a complete list of side effects and other possible side effects. Call your doctor for medical advice about side effects.

How much does Omeprazole cost?

Price of Omeprazol medicine for stomach and duodenal ulcers 20mg 30 tablets: 1,600VND/tablet – 48,000 VND/box.

How to store medicine?

  • You should store the medicine at room temperature, in a cool, dry place, away from direct sunlight.
  • You should not store the medicine in the refrigerator.
  • Keep the medicine out of the reach of children.
  • Do not throw medicine down the toilet or plumbing.

Disclaimer: Index-China goal is to provide readers with relevant and up-to-date information. However, because drugs interact differently from person to person, we cannot guarantee that this information includes all possible interactions.

This information is not a substitute for medical advice. Always talk to your doctor or healthcare provider about possible interactions with all prescription medications, vitamins, herbs, and supplements, and over-the-counter medications you’re taking.

Index-China

See also: https://index-china.com/omeprazole-medicine/

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