Ofloxacin medicine: uses, usage & dosage


What is Ofloxacin?

Ofloxacin medicine is a broad-spectrum fluoroquinolone antibiotic used to treat bacterial infections that cause bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections, and prostate infections. .

How does ofloxacin work?

Drug is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It works by inhibiting two bacterial type II topoisomerases, DNA gyrase and topoisomerase IV.

Ofloxacin drug information

  • Brand: Floxin.
  • Active ingredient name: Ofloxacin
  • Brand names: Teravox-500, Cipmyan 500, Tavanic, CILOX RVN…
  • Group of drugs: antibiotics, antiviral drugs
  • Drug form: Tablets, eye drops, solution for intravenous infusion.

What forms and strengths of drug are available?

The drug is available in the following forms and strengths:

  • Oral tablets: 200mg, 300mg, 400mg.
  • Eye drops, ear drops: ofloxacin 0.3%

Assign & contraindication to use drugs Ofloxacin

Indication of drugs

  • Severe bacterial bronchitis, pneumonia,
  • Chlamydia infection of the cervix or urethra with or without gonorrhea, uncomplicated gonorrhea, prostatitis, UTI.
  • Skin and soft tissue infections.
  • Inflammation of the colon due to bacterial infection.

Contraindications to the drug

Contraindicated in people with a history of hypersensitivity to the drug, other quinolones and/or other ingredients in the preparation.

The fluoroquinolone bactericidal drugs such as ciprofloxacin , the drug can cause cartilage degeneration in load-bearing joints in experimental animals. Therefore, it should not be used for children under 15 years old, pregnant and lactating people.

Dosage of Ofloxacin

Dosage for adults 

The usual dose of Ofloxacin is 200mg to 400mg every 12 hours.

Dosage for children

Dosage for children has not been studied and decided yet. Consult your doctor if you are giving this medicine to a child.

How to take  Drug?

Take the medicine exactly as prescribed by your doctor. Follow all directions on your medication label and read all medication instructions or instruction sheets. Your doctor may sometimes change your dose. Use the medication exactly as directed.

The effect of the drug Ofloxacin

This medication is usually taken in a strength of 200mg. This medication is used to treat a variety of bacterial infections. The drug belongs to the group of quinolone antibiotics. It works by stopping the growth of bacteria.

Antibiotics only treat bacterial infections. It is not effective for viral infections (such as common cold, flu). Unnecessary use or overuse of antibiotics can lead to reduced effectiveness.

Side effects of the drug ofloxacin

Common side effects 

  • Nausea
  • Headache
  • Sleep problems (insomnia and other sleep disorders)
  • Dizziness
  • Vaginal itching or discharge (vaginitis)
  • Diarrhea
  • Vomiting
  • Reduce cravings
  • stomach cramps
  • Chest pain
  • Itching of the external genitalia in women
  • Tired
  • Gas (flatulence)
  • Gastrointestinal (GI) Disorders
  • Worry
  • Sore throat
  • Fever
  • Skin rash/itching
  • Visual disturbances
  • Dry mouth
  • Floating
  • Change in your sense of taste / taste abnormalities
  • Jitter

Uncommon side effects 

  • Acute hepatitis
  • Acute kidney failure
  • Agranulocytosis
  • Non-regenerative anemia
  • Reduced ability to hear
  • Fainting
  • High blood pressure (hypertension)
  • Immune hypersensitivity reaction
  • Interstitial nephritis
  • Liver failure
  • Low count of red blood cells, white blood cells, and platelets (pancytopenia)
  • Low platelet count (thrombocytopenia)
  • Numbness/tingling/pain in extremities
  • Palpitations
  • Tinnitus (tinnitus)
  • Rupture of tendons and ligaments
  • Convulsions
  • Stevens-Johnson syndrome
  • Swelling (edema)
  • Thrombocytopenia purpura
  • The most crooked dictionary
  • Tourette’s syndrome
  • Toxic epidermal necrosis
  • Toxic liver damage
  • Vasculitis
  • Vasodilation

This is not a complete list of possible side effects and other serious side effects.

Ofloxacin interactions 

Some medicines can make this medicine much less effective when taken at the same time. If you take any of the following medicines, take your ofloxacin dose 2 hours before or 2 hours after you take the other medicine.

  • antacids containing calcium, magnesium, or aluminum (such as Amphojel, Di-Gel Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, Rulox, Tums, and others), or the ulcer medicine sucralfate (Carafate) ; didanosine (Videx) powder or chewable tablets.
  • vitamin or mineral supplements that contain calcium, iron, magnesium, or zinc.

Tell your doctor about all your other medicines, especially:

  • Theophylline;
  • Blood thinners (warfarin, Coumadin, Jantoven);
  • Diuretics or “water pills”;
  • Insulin or oral diabetes medication (check your blood sugar regularly);
  • Heart rhythm medication;
  • Medicines to treat depression or mental illness;
  • steroid medicine (such as prednisone); 
  • NSAIDs (nonsteroidal anti-inflammatory drugs)– aspirin , ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib , diclofenac, indomethacin, meloxicam, and others.

This list is not exhaustive. Other drugs may affect ofloxacin, including prescription and over-the-counter medicines, vitamins, and herbal products.

Be careful while using Ofloxacin

Drug may cause the following side effects:

  • Skin: Causes skin itching, vasculitis, rash and erythema, reaction to light.
  • Digestive system: Causing the patient to have nausea, vomiting, abdominal pain, diarrhea.
  • Kidney: May cause interstitial nephritis, leading to secondary acute renal failure.
  • Central nervous system: Causes dizziness, tremors, lightheadedness, paresthesias, convulsions, increased excitability.
  • Other organs: Increased eosinophils, decreased platelets and neutrophils, myalgia, decreased visual acuity, breast enlargement.

If it is Ofloxacin eye drop solution, it can cause other problems. As follows:

  • Causes allergic reactions, temporary irritation.
  • Occurrence of cross-allergic reactions.
  • Make bacteria resistant to the drug.

This is a non-exhaustive list of drug side effects. Depending on the subject and location of each person, the drug can cause other problems for the patient. Talk to your doctor for more information on this.

How much does Ofloxacin cost?

  • Ofloxacin Mekophar antibiotic 200mg box of 100 tablets: 600/tablet or 55,000/box of 100 tablets.
  • Medicines will have certain fluctuations between pharmacies and distribution agents. Users can consult prices directly at reputable drugstores nationwide.

How to store medicine?

  • You should store the medicine at room temperature, in a cool, dry place, away from direct sunlight.
  • You should not store the medicine in the refrigerator.
  • Keep the medicine out of the reach of children.
  • Do not throw medicine down the toilet or plumbing.

The above article is for reference only and is not a substitute for medical diagnosis or treatment. Readers should only follow the instructions of the doctor who is treating you, Index-China disclaims responsibility if problems occur.


See also: https://index-china.com/ofloxacin-medicine/

Reputable source Nhà thuốc Online OVN: https://nhathuoconline.org/thuoc-ofloxacin/

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