Non-small cell lung cancer (NSCLC) drug approved by the FDA

Non-small cell lung cancer (NSCLC) drug

Lung cancer is the leading cancer worldwide with nearly 1.5 million deaths each year. Several types of lung cancer drugs have been on the market for decades, but new drugs have appeared to promise better results, especially for non-small cell lung cancer (NSCLC). , accounting for 75% of lung cancer cases.

The list of non-small cell lung cancer drugs is approved by the US Food and Drug Administration (FDA). The list includes generic names and brand names. The common drug combinations are used in lung cancer. Individual drugs in combinations approved by the FDA. However, combination medications are often not approved, although they are widely used.

List of approved non-small cell lung cancer (NSCLC) drugs

Abraxane (Pacuminaxel)

Use in cancer

Paclitaxel albumin stabilized nanoparticles formula is approved for use alone or with other medications to treat:

  • Breast cancer has recurred or metastasized to other parts of the body.
  • Non-small cell lung cancer is locally advanced or metastatic and cannot be treated with surgery or radiation. It is used with carboplatin.
  • Pancreatic cancer has spread . It is used with gemcitabine hydrochloride.

Paclitaxel albumin stabilized nanoparticles formula is also being studied in the treatment of other cancers.

  • Paclitaxel albumin stabilized nanoparticles formula is a form of paclitaxel found in nanoparticles (very small protein particles).
  • The drug is also called paclitaxel nanoparticles and paclitaxel attaches proteins. This form may work better than other forms of paclitaxel and has fewer side effects.

Gilotrif (Afatinib)

Using Afatinib to treat approved cancer :

  • Non-small cell lung cancer (NSCLC) has spread to other parts of the body. It is used:
  • First-line treatment in patients with tumor with gene mutation of epidermal growth factor (EGFR).
  • In patients with NSCLC psoriasis worsens after platinum chemotherapy.

Afatinib is also being studied in the treatment of other types of cancer.

Giotrif Medicine 40mg Afatinib Used to Treat Chips (1)
Giotrif Medicine 40mg Afatinib Used to Treat Chips (1)

Afinitor (Everolimus)

Use in cancer

Everolimus is approved to treat:

  • Breast cancer : It is used in combination with exemestane in postmenopausal women with positive hormone receptor (HR +) negative HER2 (HER2-) negative disease and does not improve with letrozole treatment. or anastrozole.
  • Pancreatic cancer , gastric cancer , and lung cancer (several types): It is used in adults with advanced neurological tumors that cannot be removed with surgery, locally, or have spread spread to other parts of the body.
  • Renal cell carcinoma (a type of kidney cancer) has progressed, in adults who did not get better after treatment with sunitinib or sorafenib.
  • Giant cell adenocarcinoma : in adults and children 1 year of age and older with tuberous sclerosis and inoperable.

The use of everolimus for cancer treatment is approved for the brands Afinitor and Afinitor Disperz. Everolimus is also approved to treat graft rejection. This use is approved for the Zortress brand.

Everolimus is also being studied in the treatment of other types of cancer.

Afinitor 10mg Everolimus antagonist medication (1)
Afinitor 10mg Everolimus antagonist medication (1)

Alecensa (Alectinib)

Use in cancer

Alectinib is approved to treat:

  • Non-small cell lung cancer is anaplastic lymphoma kinase (ALK) positive and has spread to other parts of the body.
Alecensa Medicine 150mg Alectinib Antiviral Treatment (1)
Alecensa Medicine 150mg Alectinib Antiviral Treatment (1)

Alimta (Pemetrexed Disodium)

Use in cancer

Podiumrexed disodium is approved for use alone or with other medications to treat:

  • Malignant pleural mesothelioma in patients who cannot be treated with surgery.
  • Non-small cell lung cancer (some types) in patients with locally advanced or metastatic disease that has spread to other parts of the body.

Pemetrexed disodium is also being studied in the treatment of other cancers.

Alimta Medicine 100mg Pemetrexed is an effective cancer remedy (1)
Alimta Medicine 100mg Pemetrexed is an effective cancer remedy (1)

Alunbrig (Brigatinib)

Use in cancer

Brigatinib is approved to treat:

  • Non-small cell lung cancer is anaplastic lymphoma kinase (ALK) positive and has spread to other parts of the body. Brigatinib is used in cancer patients who cannot be treated with crizotinib or become worse with crizotinib.

Brigatinib is also being studied in the treatment of other types of cancer.

Tecentriq (Atezolizumab)

Use in cancer

Atezolizumab is approved for treatment:

Non-small cell lung cancer has spread (spread to other parts of the body). It is used:

  • In patients with more severe illness during or after platinum therapy. For patients with cancer that has a mutation in the epidermal growth factor receptor (EGFR) gene or anaplastic lymphoma kinase (ALK) gene, atezolizumab is used if their disease has gotten worse after treatment. with FDA -approved treatment for mutations.
  • For bevacizumab, paclitaxel and carboplatin, the first line of therapy in patients without psoriasis without the EGFR or ALK gene mutations.

Urothelial carcinoma (a type of bladder cancer) locally or has spread. It is used in:

  • Cancer patients have the PD-L1 protein and cannot be treated with cisplatin.
  • Cancer patients who cannot be treated with platinum chemotherapy or have become worse during or after platinum chemotherapy.

Atezolizumab is also being studied in the treatment of other types of cancer.

Tecentriq medicine 1200mg 20ml Atezolizumab treatment for prostate cancer symptoms (1)
Tecentriq medicine 1200mg 20ml Atezolizumab treatment for prostate cancer symptoms (1)

Avastin (Bevacizumab)

Use in cancer

Bevacizumab is approved for use alone or with other drugs to treat:

  • Cervical cancer did not get better with other treatments, had spread to other parts of the body or had recurred.
  • Colorectal cancer has spread.
  • Glioblastoma a type of brain cancer . It is used in adults with:
    • The cancer has recurred. This use is approved for Avastin’s bevacizumab trademark.
    • Cancer gets worse after other treatments. This use is approved for Mvasi’s bevacizumab trademark.
  • Nonsquamous non-small cell lung cancer is locally advanced, cannot be removed by surgery, has metastasized, or has recurred.
  • Ovarian epithelium , fallopian tube, or primary peritoneal cancer It is used in patients with stage III, stage IV or recurrent disease. This use is approved for Avastin’s bevacizumab trademark.
  • Kidney cell carcinoma has spread.

Bevacizumab is also being studied in the treatment of other types of cancer.

Alunbrig (Brigatinib)

Use in cancer

Brigatinib is approved to treat:

  • Non-small cell lung cancer is anaplastic lymphoma kinase (ALK) positive and has spread to other parts of the body. Brigatinib is used in cancer patients who cannot be treated with crizotinib or become worse with crizotinib.

Brigatinib is also being studied in the treatment of other types of cancer.

Zykadia (Ceritinib)

Use in cancer

Ceritinib is approved to treat:

  • Non-small cell lung cancer : is anaplastic lymphoma kinase (ALK) positive and has spread to other parts of the body.

Ceritinib is also being studied in the treatment of other types of cancer.

Zykadia Medicines 150mg Ceritinib antihypertensive (1)
Zykadia Medicines 150mg Ceritinib antihypertensive (1)

Xalkori (Crizotinib)

Use in cancer

Crizotinib is approved for treatment:

  • Non-small cell lung cancer : is anaplastic lymphoma kinase (ALK) positive or ROS1 positive and has spread to other parts of the body.

Crizotinib is also being studied in the treatment of other types of cancer

Xalkori medicine 250mg Crizotinib antiviral drug treatment (5)
Xalkori medicine 250mg Crizotinib antiviral drug treatment (5)

Cyramza (Ramucirumab)

Use in cancer

Ramucirumab is approved for use alone or with other drugs to treat:

  • Adenocarcinoma of stomach or gastric junction that is advanced or has metastasized spread to other parts of the body. It is used in patients with more severe illness after treatment with certain chemotherapy. It is used alone or with paclitaxel.
  • Metastatic colorectal cancer : It is used with FOLFIRI in patients with more severe illness during or after treatment with some anticancer drugs.
  • Metastatic non-small cell lung cancer : It is used with docetaxel in patients with more severe illness after treatment with certain chemotherapy. For patients with cancer that has a mutation in the epidermal growth factor receptor (EGFR) gene or anaplastic lymphoma kinase (ALK) gene, ramucirumab is used if their disease has gotten worse after treatment. with FDA -approved treatment for mutations.

Ramucirumab is also being studied in the treatment of other cancers.

Cyramza 10 mg ml of Ramucirumab is an effective cancer inhibitor (1)
Cyramza 10 mg ml of Ramucirumab is an effective cancer inhibitor (1)

Tafinlar (Dabrafenib)

Use in cancer

Dabrafenib is approved for use alone or with trametinib to treat:

  • Anaplastic thyroid cancer in patients with locally advanced or metastatic disease (spread to other parts of the body) and who cannot be treated locally. It is used with trametinib.
  • Malignant tumors it is used:
    • With trametinib in patients who have surgery to remove the cancer that has spread to the lymph nodes.
    • Alone or with trametinib in cancer patients cannot be removed by surgery or metastases.
  • Metastatic non-small cell lung cancer : It is used with trametinib.
  • Dabrafenib is used only in cancer patients with certain mutations in the BRAF gene.

Dabrafenib is also being studied in the treatment of other types of cancer.

Tafinlar 75mg Dabrafenib anti-inflammatory skin medicine (1)
Tafinlar 75mg Dabrafenib anti-inflammatory skin medicine (1)

Vizimpro (Dacomitinib)

Use in cancer

Dacomitinib is approved for treatment:

  • Non- small cell lung cancer (NSCLC) has spread to other parts of the body. It is used as first-line treatment in patients with tumors with a genetic mutation of the epidermal growth factor (EGFR).

Dacomitinib is also being studied in treating other types of cancer.

Taxotere (Docetaxel)

Use in cancer

Docetaxel is approved for use alone or with other drugs to treat:

  • Adenocarcinoma of the stomach or esophagus junction is advanced: It is used in patients who have not been treated with chemotherapy for advanced disease.
  • Breast cancer that is locally advanced or has spread has spread to other parts of the body and has not gotten better with other chemotherapy. It is also used to treat button-positive breast cancer and can be removed by surgery.
  • Non-small cell lung cancer in some patients with locally advanced or metastatic cancer.
  • Prostate cancer has spread in men with cancer that is refractory material that does not respond to hormone therapy.
  • Squamous cell carcinoma of the head and neck is locally progressive and cannot be treated with surgery.

Docetaxel is also being studied in the treatment of other types of cancer.

Imfinzi (Durvalumab)

Use in cancer

Durvalumab is approved for treatment:

  • Non-small cell lung cancer (NSCLC). It is used in patients with stage III NSCLC that cannot be removed surgically and does not get worse after platinum chemotherapy and radiotherapy.
  • Urinary carcinoma (a type of bladder cancer) that has progressed locally or has spread to other parts of the body. It is used in patients with more severe illness during or after platinum chemotherapy.

Durvalumab is also being studied in the treatment of other types of cancer.

Tarceva ( Erlotinib Hydrochloride)

Use in cancer

Erlotinib hydrochloride is approved for use alone or with other drugs to treat:

Non-small cell lung cancer (NSCLC) metastasizes and has several gene mutations of epidermal growth factor (EGFR). It can be used:

  • First-line therapy.
  • In patients who are on maintenance therapy or the disease has become worse after chemotherapy.
  • The use of erlotinib hydrochloride to treat NSCLC without EGFR gene mutations is no longer approved by the FDA.

Pancreatic cancer : It is used with gemcitabine hydrochloride in patients who are unable to undergo surgery or have metastases.

Erlotinib hydrochloride is also being studied in the treatment of other types of cancer.

Tarceva 150mg Erlotinib antagonist drug treatment (1)
Tarceva 150mg Erlotinib antagonist drug treatment (1)

Iressa (Gefitinib)

Use in cancer

Gefitinib is approved for treatment:

  • Non-small cell lung cancer (NSCLC) has spread to other parts of the body. It is used as first-line treatment in patients with tumors with a genetic mutation of the epidermal growth factor (EGFR).

Gefitinib is also being studied in the treatment of other types of cancer.

Iressa medicine 250mg Gefitinib antiviral drug treatment (1)
Iressa medicine 250mg Gefitinib antiviral drug treatment (1)

Gemzar (Gemcitabine Hydrochloride)

Use in cancer

Gemcitabine hydrochloride is approved for use alone or with other drugs to treat:

  • Metastatic breast cancer has spread to other parts of the body and has not improved with other chemotherapy. It is used with paclitaxel.
  • Non-small cell lung cancer that is advanced or has metastasized. It is used in patients who cannot be removed by surgery. It is used with cisplatin.
  • Ovarian cancer progresses and does not get better with other chemotherapy. It is used with carboplatin.
  • Pancreatic cancer has progressed or has spread. It is used in patients who cannot be removed by surgery and who have been treated with other chemotherapy. It is used with the albumin paclitaxel stabilized nanoparticle formula.

Gemcitabine hydrochloride is also being studied in the treatment of other types of cancer.

Keytruda (Pembrolizumab)

Using Pembrolizumab for approved cancer treatment :

Recurrent or metastatic cervical cancer . It is used in cancer patients with the PD-L1 protein and is more severe during or after chemotherapy.

Stomach cancer or gastric junction cancer that is frequent and either locally advanced or metastatic. It is used in cancer patients who have PD-L1 protein and more severe disease during or after two or more types of treatment including fluoropyrimidine and platinum chemotherapy and, in some cases, HER2-targeted therapy. / neu.

Hepatocellular carcinoma in patients who have been treated with sorafenib.

Hodgkin’s lymphoma in adults and children. It is used in patients with refractive disease (not responding to treatment) or has relapsed after at least three other types of treatment.

Malignant tumor . It is used in:

  • Patients with cancer cannot be removed surgically or have metastasized (metastasized to other parts of the body) or
  • The patient had surgery to remove the cancer that has spread to the lymph nodes.

Merkel cell cancer in adults and children. It is used in patients with recurrent and locally advanced or metastatic disease.

-High instability Microsatellite (MSI-H) or lack of suitable cancer repair (dMMR) that is metastatic and cannot be removed by surgery. It is used in adults and children to:

  • Solid tumors have become worse after other treatments or cannot be treated with other treatments.
  • Colorectal cancer has become worse after treatment with fluoropyrimidine, oxaliplatin and irinotecan.
  • MSI-H and dMMR can have certain gene mutations and may not respond to certain types of treatment.

Non- small cell lung cancer has spread. It is used:

  • With pemetrexed and platinum chemotherapy as first-line treatment in patients with no problem.
  • With carboplatin and either paclitaxel or paclitaxel albumin stabilizes the nanoparticle build as first-line treatment for psoriasis.
  • First-line treatment for cancer patients with PD-L1 protein and no epidermal growth factor receptor gene (EGFR) or anaplastic lymphoma kinase (ALK) gene.
  • Alone in patients with cancer who have PD-L1 protein and get worse during or after platinum chemotherapy. Cancer patients with EGFR or ALK gene mutations should only use pembrolizumab if their disease gets worse after FDA-approved therapy for these mutations.

Primary primary mediastinal lymphoma . It is used in adults and children who have a difficult to treat illness or have relapsed after at least two other therapies.

Squamous cell carcinoma of the head and neck has metastasized or recurred (returned) in patients with more severe disease during or after platinum chemotherapy.

Urinary carcinoma has progressed locally or has spread. It is used in:

  • Cancer patients have the PD-L1 protein and cannot be treated with cisplatin.
  • Cancer patients who cannot be treated with platinum chemotherapy or have become worse during or after platinum chemotherapy.

Pembrolizumab is also being studied in the treatment of other types of cancer.

Keytruda 100mg 4ml Pembrolizumab Anticholinergic Treatment (4)
Keytruda 100mg 4ml Pembrolizumab Anticholinergic Treatment (4)

Lorbrena (Lorlatinib)

Use in cancer

Lorlatinib is approved for treatment:

Non-small cell lung cancer is anaplastic lymphoma kinase (ALK) positive and has spread to other parts of the body. It is used in patients with more severe illness after treatment with:

  • Crizotinib and at least one other ALK inhibitor therapy for metastatic disease, either
  • Alectinib or ceritinib is the first ALK inhibitor for metastatic disease.

Lorlatinib is also being studied in the treatment of other types of cancer.

Mustargen (Mechlorethamine Hydrochloride)

Use in cancer

Mechlorethamine hydrochloride is approved for use in palliative treatment:

  • Bronchial carcinoma.
  • Chronic lymphocytic leukemia (CLL).
  • Chronic myeloid leukemia (CML).
  • Hodgkin’s lymphoma is advanced.
  • Malignant pleural effusion, pericardial effusion and pernicious peritoneal effusion.
  • Mycosis Mushoides a type of T-cell lymphoma in the skin.
  • Non-Hodgkin’s lymphoma (NHL).

Mechlorethamine hydrochloride is also being studied in the treatment of other cancers.

Mekinist (Trametinib)

Use in cancer

Trametinib is approved for use alone or with dabrafenib to treat:

Anaplastic thyroid cancer in patients with locally advanced or metastatic disease spread to other parts of the body and those who cannot be treated locally. It is used with dabrafenib.

Malignant tumor . It is used:

  • With dabrafenib in patients who have surgery to remove the cancer that has spread to the lymph nodes.
  • Alone or with dabrafenib in cancer patients cannot be removed by surgery or metastases.

Non-small cell lung cancer has spread. It is used with dabrafenib.

Trametinib is used only in patients with cancer who have some mutations in the BRAF gene .

Trametinib is also being studied in treating other types of cancer.

Mekinist 2mg Trametinib cure skin cancer (1)
Mekinist 2mg Trametinib cure skin cancer (1)

Rheumatrex (Methotrexate)

Use in cancer

Methotrexate is approved for use alone or with other medications to treat:

  • Acute lymphoblastic leukemia has spread to the central nervous system, or to prevent it from spreading there.
  • Breast cancer
  • Trophoblastic disease gesture.
  • Head and neck cancer of several types.
  • Lung cancer.
  • Mycosis Mushoides is an advanced type of T-cell lymphoma in the skin.
  • Non-Hodgkin’s lymphoma is advanced.
  • Osteosarcoma did not spread to other parts of the body. It is used after surgery to remove the main tumor.

Methotrexate is also being studied in the treatment of other types of cancer.

Navelbine (Vinorelbine Tartrate)

Use in cancer

Vinorelbine tartrate is approved for use alone or with cisplatin to treat:

  • Non-small cell lung cancer in patients with locally advanced disease or metastatic spread to other parts of the body.

Vinorelbine tartrate is also being studied in the treatment of other cancers.

Navelbine 30mg Vinorelbine for treating cancer (1)
Navelbine 30mg Vinorelbine for treating cancer (1)

Portrazza (Necitumumab)

Use in cancer

Necitumumab is approved for use with gemcitabine and cisplatin to treat:

  • Non-small cell lung cancer has spread to other parts of the body. It is used as first-line treatment.

Necitumumab is also being studied in the treatment of other types of cancer.

Opdivo (Nivolumab)

Use in cancer

Nivolumab is approved for use alone or with other drugs to treat:

Classic Hodgkin lymphoma in adults with recurrent (back) disease or getting worse after:

  • An autologous stem cell transplant and treatment with breduximab vedotin;
  • At least three other types of treatment include autologous stem cell transplant.

Colorectal cancer in adults and children 12 years of age and older. It is used alone or with ipilimumab to treat micro-unstable cancer (MSI-H) or poorly corrected cancer (dMMR) after worsening with fluoropyrimidine, oxaliplatin and irinotecan.

Hepatocellular carcinoma . It is used in patients who have been treated with sorafenib.

Malignant tumor . It is used:

  • In patients who are ill that cannot be surgically removed or have spread. It is sometimes used with ipilimumab.
  • In patients who have had surgery to remove the malignant tumor that has spread to the lymph nodes or has spread.

Non-small cell lung cancer has spread. It is used:

  • In patients with more severe illness during or after platinum therapy.
  • Patients with certain genetic mutations should only take nivolumab if their disease gets worse after treatment with FDA-approved therapy for gene mutations.

Advanced renal cell carcinoma . It is used:

  • In patients who have been treated with drugs that inhibit angiogenesis.
  • With ipilimumab in some patients untreated renal cell carcinoma.

Small cell lung cancer has spread. It is used in patients with more severe illness after platinum chemotherapy and at least one other therapy.

Squamous cell carcinoma of the head and neck has metastasized or recurred in patients with more severe illness during or after platinum chemotherapy.

Urothelial carcinoma (a type of bladder cancer) locally or has spread. It is used in patients with more severe illness during or after platinum chemotherapy.

Nivolumab is also being studied in the treatment of other types of cancer.

Taxol (Paclitaxel)

Use in cancer

Paclitaxel is approved for use alone or with other drugs to treat:

  • Kaposi sarcoma is related to AIDS.
  • Breast cancer
  • Non-small cell lung cancer.
  • Ovarian Cancer.

Paclitaxel is also being studied in the treatment of other types of cancer.

Paclitaxel is also available in another form called paclitaxel albumin stabilized nanoparticles formula.

Tagrisso (Osimertinib)

Use in cancer

Osimertinib is approved to treat:

  • Non-small cell lung cancer has spread to other parts of the body. It is used in patients whose tumors have some genetic mutations of epidermal growth factor (EGFR) either as first-line treatment or for more severe disease during or after treatment with an EGFR blocking drug. other.

Osimertinib is also being studied in the treatment of other types of cancer.

A combination of non-small cell lung cancer drugs is approved for use

CARBOPLATIN-TAXOL

Drugs in combination CARBOPLATIN-TAXOL:

  • Carboplatin
  • Taxol (Paclitaxel)

Use in cancer

CARBOPLATIN-TAXOL is used to treat:

  • Non-small cell lung cancer has spread.
  • Ovarian Cancer.

This combination can also be used with other drugs or treatments or to treat other types of cancer.

GEMCITABINE-CISPLATIN

The drug in the combination GEMCITABINE-CISPLATIN:

  • Gemzar (Gemcitabine Hydrochloride)
  • Cisplatin

Use in cancer

GEMCITABINE-CISPLATIN is used to treat:

  • Biliary tract cancer.
  • Bladder cancer.
  • Cervical cancer.
  • Malignant mesothelioma.
  • Non-small cell lung cancer (NSCLC).
  • Ovarian Cancer.
  • Pancreatic Cancer.

This combination can also be used with other drugs or treatments or to treat other types of cancer.

Chemotherapy is usually given in the combined form of the drug. The combination usually works better than the single drug because different drugs destroy cancer cells in different ways.

Each drug in this combination is approved by the US Food and Drug Administration (FDA) to treat cancer or cancer-related conditions.

Source of Reference Treatment medicine for Non-Small Cell Lung Cancer (NSCLC):

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