Fucoidan inhibits pneumonia radiation and pulmonary fibrosis

Fucoidan inhibits radiation pneumonia and pulmonary fibrosis

Fucoidan inhibits pneumonia radiation and pulmonary fibrosis by reducing the expression of cytokine causing inflammation in lung tissues.

Overview Fucoidan inhibits pneumonia

Radiation therapy is an important treatment for many types of cancer. Radiation pneumonia (RP) is one of the main complications in chest irradiation.

Fucoidan is a sulfated polysaccharide found mainly in various brown seaweeds. Recent studies have demonstrated the anti-inflammatory effects of fucoidan.

However, no studies have reported a good prophylactic agent for RP. Therefore, we studied the effects of Fucoidan on RP and pulmonary fibrosis due to radiotherapy (RT).

Fucoidan for the protection of Chips by Chips and Chips (5)
Fucoidan for the protection of Chips by Chips and Chips (5)

Materials and methods

The researchers compared pneumonia (RP) and radiation-induced pulmonary fibrosis (RT) in lung tissue samples obtained from irradiation (10 Gy / shot) C57BL / 6 mice with or without Fucoidan (200) mg / kg / day, gargle for 14 days).

Samples of cytokine expression in pleural fluid were determined using a cytokine array and confirmed through enzyme immunoassay.

Research results

Fucoidan use weakens RP and fibrosis due to RT in lung tissue. Decreased neutrophil and macrophage accumulation has been observed in irradiated lung tissue and radiation-induced pulmonary fibrosis, as demonstrated by Masson trichrom staining, has been impaired.

Fucoidan for the protection of Chips by Chips and Chips (4)
Fucoidan for the protection of Chips by Chips and Chips (4)
Fucoidan for the protection of Chips by Chips and Chips (2)
Fucoidan for the protection of Chips by Chips and Chips (2)
Fucoidan for the protection of Chips by Chips and Chips (3)
Fucoidan for the protection of Chips by Chips and Chips (3)

The researchers studied expression patterns of inflammatory cytokines in pleural fluid irradiated via protein arrays, which showed that Fucoidan changed the expression pattern of inflammatory cytokines in lung tissues. irradiated.

Fucoidan for the protection of Chips by Chips and Chips (1)
Fucoidan for the protection of Chips by Chips and Chips (1)

In addition, the expression levels of TIMP-1, CXCL1, MCP-1, MIP-2 and interleukin-1Ra were significantly enhanced in pleural fluid, Fucoidan significantly reduced their manifestations.

Fucoidan for the protection of Chips by Chips and Chips (6)
Fucoidan for the protection of Chips by Chips and Chips (6)

Conclude

This study demonstrated that the expression of cytokine causing inflammation after irradiation of the whole lung was correlated with neutrophil accumulation and radiation fibrosis.

Interestingly, Fucoidan changes the inflammatory expression pattern of cytokines that can lead to radioactive pneumonia and fibrosis decline. It is likely to be a therapeutic molecule to reduce or prevent radiation-induced pneumonia.

Note: This summary is not presented at the discussion

Reference Source Fucoidan inhibits radiation pneumonia and pulmonary fibrosis:

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