Fucoidan inhibits pneumonia radiation and pulmonary fibrosis by reducing the expression of cytokine causing inflammation in lung tissues.
Overview Fucoidan inhibits pneumonia
Radiation therapy is an important treatment for many types of cancer. Radiation pneumonia (RP) is one of the main complications in chest irradiation.
Fucoidan is a sulfated polysaccharide found mainly in various brown seaweeds. Recent studies have demonstrated the anti-inflammatory effects of fucoidan.
However, no studies have reported a good prophylactic agent for RP. Therefore, we studied the effects of Fucoidan on RP and pulmonary fibrosis due to radiotherapy (RT).
Materials and methods
The researchers compared pneumonia (RP) and radiation-induced pulmonary fibrosis (RT) in lung tissue samples obtained from irradiation (10 Gy / shot) C57BL / 6 mice with or without Fucoidan (200) mg / kg / day, gargle for 14 days).
Samples of cytokine expression in pleural fluid were determined using a cytokine array and confirmed through enzyme immunoassay.
Fucoidan use weakens RP and fibrosis due to RT in lung tissue. Decreased neutrophil and macrophage accumulation has been observed in irradiated lung tissue and radiation-induced pulmonary fibrosis, as demonstrated by Masson trichrom staining, has been impaired.
The researchers studied expression patterns of inflammatory cytokines in pleural fluid irradiated via protein arrays, which showed that Fucoidan changed the expression pattern of inflammatory cytokines in lung tissues. irradiated.
In addition, the expression levels of TIMP-1, CXCL1, MCP-1, MIP-2 and interleukin-1Ra were significantly enhanced in pleural fluid, Fucoidan significantly reduced their manifestations.
This study demonstrated that the expression of cytokine causing inflammation after irradiation of the whole lung was correlated with neutrophil accumulation and radiation fibrosis.
Interestingly, Fucoidan changes the inflammatory expression pattern of cytokines that can lead to radioactive pneumonia and fibrosis decline. It is likely to be a therapeutic molecule to reduce or prevent radiation-induced pneumonia.
Note: This summary is not presented at the discussion
Reference Source Fucoidan inhibits radiation pneumonia and pulmonary fibrosis:
- Source ncbi.nlm.nih.gov bài viết Fucoidan Inhibits Radiation-Induced Pneumonitis and Lung Fibrosis by Reducing Inflammatory Cytokine Expression in Lung Tissues: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213111/, cập nhật 19/10/2018.
- A reputable source index-china.com summarizes the article Fucoidan inhibits radiation pneumonia and pulmonary fibrosis : https://index-china.com/fucoidan-inhibits-pneumonia/, updated 14/3/2020.
Assoc.Prof.Dr. Tran Ngoc Anh is currently Hanoi Medical University Hospital, Associate Professor, Department of Internal Medicine, Gastroenterology and Head of Department of General-Uematology of Hanoi Medical University. Consulting doctor at ThuocLP Vietnamese health.
Professional qualifications, Academic degrees – Education:
Graduated from General Practitioner System, Hanoi Medical University
Graduated with a Master degree in Internal Medicine, Hanoi Medical University
Graduated from the training program specialized in Gastrointestinal, Henri Mondor Institute Center, University of Paris 6, French Republic 1996-1997; 1999
Graduated from the training program specialized in Gastrointestinal, North Royal Sydney Hospital, Australia; 2002
Graduated from a training program specialized in chronic liver diseases, Pizza, Italy 2009
Graduated with a PhD in Gastrointestinal, Hanoi Medical University
Associate Professor, Gastroenterology, Hanoi Medical University
Training and Scientific Research:
Published more than 200 articles in domestic and international specialized journals
Editor of many monographs and participates in compiling 2 textbooks.
Guide many students and graduate students of Hanoi Medical University
Manager of many grassroots research projects
Certificate of Good Clinical Practice (GCP: 2012, 2015), Ministry of Health
Specialized certificates: General gastrointestinal endoscopy, Interventional gastrointestinal endoscopy, General gastrointestinal ultrasound, Interventional gastrointestinal ultrasound (Bach Mai BV), Chronic liver disease.