Erythromycin medicine: uses, usage & Dosage

erythromycin-medicine-uses-usage-dosage

What is Erythromycin?

Erythromycin medicine belongs to a group of drugs known as macrolide antibiotics. Macrolide antibiotics slow the growth of, or sometimes kill, susceptible bacteria by reducing the production of important proteins that bacteria need to survive.

Information on antiseptic solution erythromycin

  • Registration Number: VD-31979-19
  • Active ingredient: Erythromycin (as Erythromycin ethyl succinate)
  • Dosage form: Powder for oral suspension
  • Packing: Box of 20 packs x 3g
  • Expiry date: 36 months

How does erythromycin work?

Erythromycin, like all macrolide antibiotics, prevents bacterial cells from growing and multiplying by interfering with their ability to make proteins while not affecting human cells. Bacteria such as Haemophilus influenzae are resistant only to the drug and must be treated with a combination of erythromycin and an adequate dose of a sulfonamide.

What are the forms and strengths of erythromycin?

  • Slow-release granules in capsules, orally, as base: 250mg.
  • Ready-made solution, Intravenous, lactobionate salt form: 500mg, 1000mg.
  • Prepared suspension, oral, ethylsuccinate salt form: 200mg/5ml (100ml); 400mg/5mL (100 mL).
  • Tablets, base form: 250mg, 500mg.
  • Tablets, ethylsuccinate form: 400mg.
  • Tablets, stearate: 250mg.
  • Tablets, slow release, base: 250mg, 333mg, 500mg.

Indications & contraindications to the use of the drug erythromycin

Erythromycin is an antibiotic in the class of antibiotics known as macrolide antibiotics, which also includes azithromycin (Zithromax, Zmax) and clarithromycin (Biaxin).

Indication of drugs

It is widely used to treat infections, such as pneumonia , skin problems, such as acne and rosacea, tooth abscesses, and other sexually transmitted infections. sex .

Erythromycin is used in children, usually to treat ear infections or chest infections.

This medication is also available as a skin solution to treat skin infections such as acne. It can be given by injection, but this is usually only done in a hospital.

Contraindications to the drug

  • The drug is contraindicated in patients with hypersensitivity to any of the ingredients.
  • Patients who have previously received Erythromycin with liver disorders, patients with a history of deafness, patients with acute porphyria.
  • Combined with Terfenadine, Astemizole.

What is the dose of erythromycin?

Dosage of erythromycin for adults 

Usual Adult Dose for Campylobacter Gastroenteritis:

  • Mild to moderate infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours.
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.

Usual Adult Dose for Mild Chancroid:

  • Mild to moderate infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.

Usual Adult Dose for Diarrhea:

  • Mild to moderate infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.

Usual Adult Dose for Mycoplasma pneumonia:             

  • Mild to moderate infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.

Usual Adult Dose for Nongonococcal urethritis:

  • Mild to moderate infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.

Usual Adult Dose for otitis media:

  • Mild to moderate infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.

Usual Adult Dose for Pharyngitis:

  • Mild to moderate infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.
  • Usual Adult Dose for Pneumonia: Mild to Moderate Infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.

Usual Adult Dose for Infections of the Family or Soft Tissue:

  • Mild to moderate infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.

Usual Adult Dose for Syphilis – Early Stage: 

  • Mild to moderate infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.

Usual Adult Dose for Upper Respiratory Tract Infections:

  • Mild to moderate infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.

Usual Adult Dose for Bronchitis :

  • Mild to moderate infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.

Usual Adult Dose for Chlamydia Infection:

  • Mild to moderate infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.
  • Usual Adult Dose for Lyme Disease: Mild to moderate infections: 250 to 500 mg (base, estolate, stearate) or 400 to 800 mg (ethylsuccinate) orally every 6 hours
  • Severe infections: 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.

Usual Adult Dose for Legionella Pneumonia: 

  • Although a dose has not been determined, clinical trials have used 1g to 4g/day parenterally in equal doses every 6 hours or as a continuous infusion.

Dosage in adults for the prevention of endocarditis infection:

  • 1 g (stearate) or 800 mg (ethylsuccinate) orally every 2 hours before the procedure, then half the dose 6 hours after the first dose.

Usual Adult Dose for Bowel Surgery: 

  • 1 g (base) orally at 1, 2 pm, and 11 pm the day before surgery (eg surgery at 8 am); take with 1g of neomycin and bowel cleansing (bowel evacuants).

Usual Adult Dose for Rheumatic Fever Prophylaxis: 

  • 250 mg orally twice a day.

Dosage of erythromycin for children 

Usual pediatric dose for the prevention of endocarditis infection: 

  • 20 mg/kg (ethylsuccinate or stearate) orally every 2 hours before the procedure, then half the dose 6 hours after the first dose.

Usual Pediatric Dose for Bowel Surgery: 

  • 20 mg/kg (base) orally at 1, 2 pm, and 11 pm the day before surgery (eg surgery at 8 am); take with 1g of neomycin and clean the intestines

Usual Pediatric Dose for Pneumonia: 

  • Chlamydia neonatal conjunctivitis and pneumonia: 50 mg/kg/day orally in equal doses every 6 hours for at least 2 weeks.

Usual Pediatric Dose for Chlamydia Infection: 

  • Chlamydia neonatal conjunctivitis and pneumonia: 50 mg/kg/day orally in equal doses every 6 hours for at least 2 weeks.

Usual Pediatric Dose for Rheumatic Fever Prophylaxis: 

  • 250 mg orally twice a day.

Usual Pediatric Dose for Pertussis: 

  • 40-50 mg/kg/day, orally, in divided doses every 6 hours for 14 days; Maximum dose: 2g/day (not suitable for children under 1 month old).

How to take erythromycin?

Take erythromycin exactly as prescribed by your doctor. Follow all directions on your medication label and read all medication instructions or leaflets. Your doctor may sometimes change your dosage. Use the medicine exactly as directed.

  • Medicine taken orally.
  • Erythromycin injection is given into a vein for severe infections. 

Precautions while using erythromycin

Cases of severe diarrhea during or after treatment with erythromycin suggest the possibility of pseudomembranous colitis as some rare cases have been reported with drug, as well as with all antiretroviral agents. born.

In case of liver failure, the drug is not recommended. If necessary, liver function tests should be monitored regularly and the dose may be reduced.

Rarely, atypical ventricular tachycardia (torsades de pointes) has been reported with oral or intravenous erythromycin; however, the drug should be used with caution in patients with a prolonged QT interval.

Due to the presence of sucrose, this drug is contraindicated in patients with fructose intolerance, glucose and galactose malabsorption syndrome, or sucrase-isomaltase deficiency.

Side effects of the drug erythromycin

Common side effects

    • Feeling nauseous (nausea)
    • Sickness (vomiting) and diarrhea
    • My stomach cramps
    • Loss of appetite
  • Stomach full and indigestion 

Serious side effects

  • Rash
  • Itching
  • Hive
  • Difficulty breathing or swallowing
  • Wheeze
  • Yellow skin or eyes
  • Dark urine
  • Pale stools
  • Unusual fatigue
  • Pain in the upper right part of the stomach
  • Convulsions
  • Fast, pounding, or irregular heartbeat
  • Severe diarrhea (watery or bloody stools) that may or may not occur with fever and stomach cramps (may occur up to 2 months or more after treatment)

Erythromycin interactions 

There are a number of drugs that do not combine well with erythromycin. Tell your doctor if you are taking these medicines before you start taking erythromycin:

  • Antihistamines, such as astemizole, terfenadine, or mizolastine.
  • An illness-fighting medicine called domperidone.
  • Medicines for mental health problems are called pimozide and amisulpride.
  • Migraine medications are called ergotamine and dihrydroergotamine.
  • A cholesterol-lowering drug called simvastatin.
  • A medicine that weakens the bladder is called tolterodine.

How much does Erythromycin cost?

  • The selling price of erythromycin on the market today is about 125 VND/box of 500mg (100 tablets).
  • Medicines will have certain fluctuations between pharmacies and distribution agents. Users can consult prices directly at reputable drugstores nationwide.

How to store medicine?

  • You should store the medicine at room temperature, in a cool, dry place, away from direct sunlight.
  • You should not store the medicine in the refrigerator.
  • Keep the medicine out of the reach of children.
  • Do not throw medicine down the toilet or plumbing.

Note:  Information about the above article about erythromycin related to the effects of the drug and how to use it for the purpose of sharing knowledge, introducing information about the drug for medical staff and patients’ reference. Each case and location will have its own prescription and treatment. Patients are not allowed to arbitrarily use drugs, all information on drug use must be prescribed by a specialist doctor.

Index-China

See also: https://index-china.com/erythromycin-medicine/

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