Cofidec medicine: Uses, dosage & usage


What is Cofidec?

Cofidec medicine is a non-steroidal anti-inflammatory drug (NSAID). It works by reducing the hormones that cause inflammation and pain in the body. It is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual cramps.

Uses of Cofidec

Cofidec drug has the main effect of analgesic, antipyretic, anti-inflammatory, Cofidec drug is used in anti-arthritis, supporting moderate and mild pain relief.

Drug information Cofidec 200

  • Active ingredient: Celecoxib
  • Type of drug: Non-steroidal anti-inflammatory drugs (NSAIDs), drugs for arthritis
  • Drug form, strength: Box of 2 blisters x 10 hard capsules, Celecoxib 200mg.
  • Expiry date: 24 months.
  • Group of analgesics – anti-inflammatory drugs

Indications for use of the drug

  • Reduce signs & symptoms of osteoarthritis, rheumatoid arthritis in adults.
  • Cofidec is used to control acute pain in adults, including toothache.
  • Treatment of primary dysmenorrhea.

Contraindications to use

  • Hypersensitivity to any ingredient of Cofidec.
  • People allergic to sulfonamides.
  • The drug should not be used by pregnant/lactating women.
  • Severe heart/kidney/liver failure, inflammatory bowel disease (Crohn’s disease, ulcerative colitis ).

What is the dose of Cofidec?

Osteoarthritis: The recommended usual daily dose is 200mg, taken once a day or in 2 divided doses. In patients with inadequate symptom relief, an increase in dose to 200 mg twice daily may increase efficacy.

Rheumatoid Arthritis:  The recommended starting dose of Cofidec is 200mg daily in 2 divided doses. If necessary, this dose may be subsequently increased to 200 mg twice daily.

Ankylosing spondylitis:  The recommended daily dose is 200mg, taken once a day or divided into 2 times. In some patients with inadequate symptom relief, dose increases to 400 mg once daily or in two divided doses may increase efficacy.

In the absence of increased therapeutic benefit after 2 weeks, other treatment options should be considered. The maximum recommended daily dose is 400mg for all indications.

How to take Cofidec 200mg?

Cofidec drug can be taken once or divided into 2 equal times, both have the same effect in the treatment of osteoarthritis – joints.

For rheumatoid arthritis, the dose should be divided equally into 2 times, can be taken without regard to meals, higher doses (ie 400mg/time, twice a day) must be taken with meals (with meals) food) to improve absorption.

Advice from experts at Hanoi University of Medicine and Pharmacy

You should not use Cofidec if you are allergic to it or if you have:

  • Allergy to sulfa drugs;
  • History of asthma attack or severe allergic reaction after taking aspirin or an NSAID.

To make sure Cofidec is safe for you, tell your doctor if you have ever had:

  • stomach ulcers, bleeding in your stomach or intestines;
  • Heart disease, high blood pressure;
  • Asthma;
  • Blood problems;
  • Liver or kidney disease;
  • If you smoke or drink alcohol.

Taking Cofidec during the last 3 months of pregnancy can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

This medicine may affect fertility (ability to have children) in women. Ask your doctor about this risk. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risks.

Cofidec side effects

Get emergency medical help if you have signs of an allergic reaction to celecoxib (hives, trouble breathing, swelling in your face or throat) or a serious skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stop using Cofidec and call your doctor at once if you have:

  • The first sign of any skin rash, no matter how mild;
  • heart problems–swelling, rapid weight gain, feeling short of breath;
  • signs of stomach bleeding–bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • liver problems–nausea, stomach pain (upper right), itching, tiredness, dark urine, jaundice (yellowing of the skin or eyes);
  • kidney problems–little or no urinating, swollen feet or ankles, feeling tired or short of breath;
  • Low red blood cells (anemia) – pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

Common side effects of Cofidec may include:

  • Stomach pain, heartburn, flatulence, diarrhea, constipation, nausea, vomiting;
  • Swelling in your hands or feet;
  • Dizziness;
  • Cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and other possible side effects. Call your doctor for medical advice about side effects.

Cofidec 200 drug interactions

Drugs that can cause interactions with celecoxib are listed below:

  • Blood thinners, anticoagulants.
  • Combining warfarin and celecoxib increases the risk of bleeding.
  • Mental health drugs.
  • The active ingredient Celecoxib in Cofidec can increase the level of lithium in your body. Signs of lithium toxicity include slurred speech and tremors.
  • Blood pressure medication.

Celecoxib may reduce the blood pressure lowering effects of some blood pressure medicines. Examples of these drugs include:

  • ACE inhibitors (ACEs).
  • Angiotensin II receptor blockers.
  • Diuretic.
  • Implant medicine.
  • Combining cyclosporine and celecoxib increases the risk of kidney damage.
  • Cancer treatment drugs.

Taking Cofidec with certain medicines used to treat cancer increases the risk of side effects from those drugs. These side effects include kidney damage and a decrease in the cells that help you fight infections. Examples of these drugs include:

  • methotrexate;
  • pemetrexed.

Other NSAIDs

Cofidec is a non-steroidal anti-inflammatory drug (NSAID). Combining it with other NSAIDs increases the risk of side effects. Examples of other NSAIDs include:

  • ibuprofen;
  • naproxen;
  • aspirin;
  • Corticosteroid;
  • Combining celecoxib with corticosteroids such as prednisone increases the risk of gastric bleeding.


If you take celecoxib together with digoxin, the level of digoxin in your body may increase. If you take these medicines together, your doctor may monitor your digoxin levels.

What warnings when using Cofidec?

For people with heart disease: If you have a history of heart disease or are at risk for heart disease, you should not take Cofidec. It increases the risk of blood clots, heart attack and stroke.

For people with stomach problems: If you have a history of bleeding or stomach ulcers, you’re more likely to develop ulcers or bleeding, which can be fatal.

For people who are allergic to “sulfa” sulfonamides: If you are allergic to medicines that contain sulfonamides, you should not take this medicine. This medicine contains a sulfonamide. You may have a serious skin reaction. Report any skin rash to your doctor right away.

For pregnant & lactating women

For pregnant women: Studies have shown a risk of adverse effects on the fetus when the mother takes Cofidec. Tell your doctor if you are pregnant or plan to become pregnant. This medicine should be used during pregnancy only if possible benefit to the fetus.

For women who are breast-feeding: This medicine has been shown to pass into breast milk. You and your doctor should decide whether you will take this medicine or breastfeed.

How to store medicine?

  • You should store the medicine at room temperature, in a cool, dry place, away from direct sunlight.
  • You should not store the medicine in the refrigerator.
  • Keep the medicine out of the reach of children.
  • Do not throw medicine down the toilet or plumbing.

The above article is for reference only and is not a substitute for medical diagnosis or treatment. Readers should only follow the instructions of the doctor who is treating you, Index-China disclaims responsibility if problems occur.


See also:

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