Carbamazepine medicine: Uses, dosage & usage

carbamazepine-medicine-uses-dosage-usage

What is Carbamazepine?

Carbamazepine medicine is used to prevent and control seizures. It is also used to relieve some types of nerve pain (such as trigeminal neuralgia). This medication works by reducing the spread of seizures in the brain and restoring a normal balance of nerve activity.

What are the uses of Carbamazepine?

  • Carbamazepine is indicated for the treatment of partial seizures with complex symptoms (psychomotor epilepsy, temporal lobe epilepsy).
  • Generalized epileptic status (tonic-clonic convulsion).
  • Complex types of epilepsy include the above or types of seizures
  • other local or global.
  • Trigeminal neuralgia: Drugs used to relieve pain in trigeminal neuralgia and also beneficial in lingual oropharyngeal neuralgia.

Carbamazepine drug information

  • International generic name: Carbamazepine.
  • Drug Type: Antiepileptic.
  • Group: psychoactive drugs

Drug form and strength

Tablets: 200 mg. Chewable tablets: 100 mg; 200 mg. Slow-release tablets: 100 mg; 200 mg; 400 mg. Oral suspension: 100 mg/5 ml.

Rectal suppository 125mg, 250mg.

Indications for the use of Carbamazepine

Epilepsy: Partial seizures with complex symptoms (psychomotor and temporal lobe epilepsy). People with this type of epilepsy appear to respond better to drugs than other types of epilepsy. Major seizures (generalized tonic-clonic seizures). Mixed seizure types include the above, or other types of partial or generalized seizures. Absence seizures (miniature seizures) unresponsive to carbamazepine .

Trigeminal neuralgia: Relieves true trigeminal neuralgia, and relieves glossopharyngeal neuralgia.

Other indications: Prophylaxis of manic-depressive illness {unresponsive to conventional therapy (eg, lithium, antipsychotics)}. Treatment of alcohol withdrawal syndrome. Nerve pain relief.

Contraindications to the use of Carbamazepine

Acute porphyria, hypersensitivity to carbamazepine or allergy to structurally related drugs such as tricyclic antidepressants, atrioventricular block, history of hematopoietic disorders and myelosuppression.

What is the dose of Carbamazepine?

Dosage for adults:

Usual adult dosage of carbamazepine for epilepsy:

  • Initial dose: 200 mg orally twice a day (for extended-release and rapid-release tablets) or 100 mg orally 4 times a day (for suspension).
  • You then increase the weekly dose by 200 mg/day, using the extended-release tablet twice daily or three times a day or four times a day with the other formulations.
  • Maintenance dose: you take 800-1200 mg/day.
  • Maximum dose: generally you should not exceed 1200 mg/day. However, doses up to 1600 mg/day have been used in rare cases.

Usual adult dosage of carbamazepine for neuralgia:

  • Initial dose: 100 mg orally twice a day (for extended-release and rapid-release tablets) or 50 mg orally 4 times a day (for suspension).
  • You may increase your dose by 200 mg/day by using an additional 100 mg every 12 hours (for extended-release and rapid-release formulations) or 50 mg four times a day (for suspension). only when necessary for pain relief.
  • Maximum dose: do not exceed 1200 mg/day.
  • Maintenance dose: you take 400-800 mg/day.

Usual adult dosage of carbamazepine for bipolar disorder:

Initial dose: 200 mg orally as a tablet or capsule every 12 hours or 100 mg of oral solution 4 times a day.

For tablets and solutions:

  • Once tolerated, you may need to increase the dose to maintain drug levels in the therapeutic range of 6-12 mcg/mL. The daily dose should be increased by 100-200 mg over 1-2 weeks.
  • Maintenance dose: You can take up to 1200 mg/day divided into 3 or 4 doses to maintain concentrations within the therapeutic range.

For extended-release capsules:

  • Dosage must be titrated to 200 mg/day (in increments of 100 mg twice daily) to achieve optimal clinical response. Doses higher than 1600 mg/day have not been studied.
  • Usual Adult Dose for Diabetic Neuropathy:
  • Initial dose: you take 100 mg orally as a tablet every 12 hours or use 50 mg of oral solution 4 times a day.
  • The daily dose should be increased to 100 mg at 1-2 weeks.
  • Maintenance dose: 600-1200 mg per day divided into 3 or 4 doses. This dose may be necessary to maintain concentrations within the therapeutic range.

Dosage for children:

Usual pediatric dosage of carbamazepine for epilepsy:

For children under 6 years old:

Initial dose: you use 10-20 mg / kg / day for children to take 2-3 doses (tablet form) or divided into 4 times (medicine suspension). You may give your child a weekly increase in dose to achieve an optimal clinical response.

Maximum dose: 35 mg/kg/day.

For children 6-12 years old:

Initial dose: you give your child 100 mg orally twice a day (extended-release or rapid-release tablets) or 50 mg orally 4 times a day (suspension). You can increase your weekly dose by 100 mg/day, by using extended-release tablets twice daily or three times a day or four times a day with other formulations.

Maintenance dose: 400-800 mg/day.

Maximum dose: 1000 mg/day.

For 12 year olds:

Initial dose: 200 mg orally twice a day (extended-release or rapid-release tablets) or 100 mg orally 4 times a day (suspension). You can give your child an increased weekly dose of 200 mg/day, using the extended-release tablet twice daily or three times a day or four times a day with other formulations.

Maintenance dose: 800-1200 mg/day.

In general, you should not exceed 1000 mg for children 12-15 years of age and 1200 mg/day for children over 15 years of age.

Doses up to 1600 mg/day have been used in rare cases.

How to take Carbamazepine

  • Take carbamazepine after eating.
  • Swallow the extended-release tablet or capsule whole and do not crush, chew, or break it.
  • The chewable tablet must be chewed before you swallow it.
  • Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided or use the dosing device (not the kitchen spoon).
  • It may take up to 4 weeks before your symptoms improve. Keep using it as directed and call your doctor at once if carbamazepine seems to stop working as well as preventing your seizures.

Precautions while using Carbamazepine

Drinking alcohol with the drug carbamazepine can cause side effects and may also increase the risk of seizures.

Grapefruit can interact with carbamazepine and lead to unwanted side effects. Avoid using grapefruit products.

Avoid driving or hazardous activities until you know how this medicine will affect you. Your reaction may be impaired.

Carbamazepine side effects

Call your doctor right away if you have:

  • skin rash, no matter how mild;
  • loss of appetite, right upper abdominal pain, dark urine;
  • slow, fast, or pounding heartbeats;
  • anemia or other blood problems–fever, chills, sore throat, mouth sores, bleeding gums, nosebleeds, pale skin, easy bruising, unusual tiredness, feeling light-headed or short of breath; or
  • low sodium levels–headache, confusion, severe weakness, feeling unsteady, increased seizures.

Common side effects of carbamazepine may include:

  • dizziness, loss of coordination, problems with walking;
  • nausea, vomiting ; or
  • asleep.

This is not a complete list of side effects and other possible side effects.

Carbamazepine interactions

Sometimes it is not safe to use several medicines at the same time. Some medicines can affect your blood levels of other medicines you take, which could increase side effects or make them less effective.

Using carbamazepine with other medicines that make you sleepy can worsen this effect. Ask your doctor before using an opioid, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Many drugs can interact with carbamazepine, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any you start or stop using.

How to store drug?

  • You should store carbamazepine at room temperature, in a cool, dry place, away from direct sunlight.
  • You should not store carbamazepine in the refrigerator.
  • Keep carbamazepine out of the reach of children.
  • Do not throw carbamazepine down the toilet or plumbing.

The above article is for reference only and is not a substitute for medical diagnosis or treatment. Readers should only follow the instructions of the doctor who is treating you, Index-China disclaims responsibility if problems occur.

Index-China

See also: https://index-china.com/carbamazepine-medicine/

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